Complement deficiency is an immunodeficiency of absent or suboptimal functioning of one of the complement system proteins.[4] Because of redundancies in the immune system, many complement disorders are never diagnosed. Some studies estimate that less than 10% are identified.[5]Hypocomplementemia may be used more generally to refer to decreased complement levels,[6] while secondary complement disorder means decreased complement levels that are not directly due to a genetic cause but secondary to another medical condition.[7]
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^Winkelstein, Jerry A. (2004). "The Complement System". In Gorbach, Sherwood L.; Bartlett, John G.; Blacklow, Neil R. (eds.). Infectious Diseases. Lippincott Williams & Wilkins. pp. 8–13. ISBN 978-0-7817-3371-7.
^Sjöholm, A.G.; Jönsson, G.; Braconier, J.H.; Sturfelt, G.; Truedsson, L. (2006). "Complement deficiency and disease: An update". Molecular Immunology. 43 (1–2): 78–85. doi:10.1016/j.molimm.2005.06.025. PMID 16026838. – via ScienceDirect(Subscription may be required or content may be available in libraries.)
^Moreland, Larry W., ed. (2004). Rheumatology and Immunology Therapy: A to Z Essentials. Berlin: Springer. p. 425. ISBN 9783540206255. Archived from the original on 12 January 2023. Retrieved 30 August 2016.
^Complement-Related Disorders at eMedicine
and 28 Related for: Complement deficiency information
Complementdeficiency is an immunodeficiency of absent or suboptimal functioning of one of the complement system proteins. Because of redundancies in...
The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies...
Complement 3 deficiency is a genetic condition affecting complement component 3 (C3). People can suffer from either primary or secondary C3 deficiency...
of the complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible...
bradykinin formation is caused by continuous activation of the complement system due to a deficiency in one of its prime inhibitors, C1-esterase (aka: C1-inhibitor...
Terminal complement pathway deficiency is a genetic condition affecting the complement membrane attack complex (MAC). It involves deficiencies of C5, C6...
Asplenia, where there is no function of the spleen Complementdeficiency is where the function of the complement system is deficient In reality, immunodeficiency...
cases with C1-inhibitor deficiency. C1-inhibitor deficiency is caused by mutations of the SERPING1 gene, the gene encoding complement C1-inhibitor. More than...
the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases. The Complement system...
Complement 2 deficiency is a type of complementdeficiency caused by any one of several different alterations in the structure of complement component...
Complement 4 deficiency is a genetic condition affecting complement component 4. It can present with lupus-like symptoms. Parija (2009). Textbook of Microbiology...
cells, killing them. Lack of regulation of the classical complement pathway through the deficiency in C1-inhibitor results in episodic angioedema. C1-inhibitor...
the complement membrane attack complex. Deficiency is thought to cause Leiner's disease. Complement component 5 is the fifth component of complement, which...
the C1 complex (C1qr2s2), the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis...
Schwartz RA, Thomas I. "Complement Receptor Deficiency: eMedicine Dermatology". Medscape. Retrieved 7 December 2010. Complement+receptors at the U.S. National...
Properdin deficiency is a rare X-linked disease in which properdin, an important complement factor responsible for the stabilization of the alternative...
but this is rare. When a single gene deficiency does cause lupus, it is usually attributed to the complement protein genes C1, C2, or C4. The influence...
CD55 deficiency, also called DAF deficiency or CHAPLE syndrome, is a rare genetic disorder of the immune system. CHAPLE stands for "CD55 deficiency with...
and C4 by immune complex-induced inflammation or to congenitally complementdeficiency, which may predispose to SLE. Renal disorder: More than 0.5 g per...
of the complement cascade, such that complement proteins remain in check and do not lead to unnecessary activity. When there is a deficiency of C1-INH...
C3/C4 values but a decreased CH50, that can indicate a terminal complement pathway deficiency while if one has low C3 and CH50 values that can indicate an...
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system...
MBL deficiency or mannose-binding lectin deficiency is an illness that has an impact on immunity. Low levels of mannose-binding lectin, an immune system...
pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, in that, after activation, it proceeds...
inherited disorder of the metabolism of the amino acid methionine due to a deficiency of cystathionine beta synthase or methionine synthase. It is an inherited...
such anatomical abnormalities, 36% are due to immune deficiencies (such as complementdeficiency, which predisposes especially to recurrent meningococcal...
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