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Complement component 2 information


C2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC2, ARMD14, CO2, complement component 2, complement C2
External IDsOMIM: 613927; MGI: 88226; HomoloGene: 45; GeneCards: C2; OMA:C2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013484

RefSeq (protein)

NP_038512

Location (UCSC)Chr 6: 31.9 – 31.95 MbChr 17: 35.08 – 35.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement C2 is a protein that in humans is encoded by the C2 gene.[5] The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases.[5]

The Complement system is generated to regulate self protection from infection. The overall Complement system is composed of protein groups that collaborate in destroying foreign invaders, which ultimately remove debris from cells and tissues. When the body detects a foreign invader, the body signals the Complement system and the Complement component 2 protein attaches to Complement system 4 resulting in an immune response. Complement component 2 protein is critical for regulating the body's immune response.

  1. ^ a b c ENSG00000235017, ENSG00000235696, ENSG00000226560, ENSG00000204364, ENSG00000166278, ENSG00000231543 GRCh38: Ensembl release 89: ENSG00000206372, ENSG00000235017, ENSG00000235696, ENSG00000226560, ENSG00000204364, ENSG00000166278, ENSG00000231543 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024371 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: C2 complement component 2".

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Complement component 2

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The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together...

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Complement component 4

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Complement component 5

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Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved...

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Complement component 5a

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cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments. C5b is important in late events of the complement cascade, an...

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Complement component 1r

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with C1q and C1s form the C1 complex, which is the first component of the serum complement system. C1r is an enzyme that activates C1s to its active...

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Complement component 1s

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Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system...

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Complement 2 deficiency

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Complement 2 deficiency is a type of complement deficiency caused by any one of several different alterations in the structure of complement component...

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Complement system

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component of fresh serum. Ehrlich, therefore, named this heat-labile component "complement", because it is something in the blood that "complements"...

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Complement component 4B

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Complement component 4B (Chido blood group) is a kind of the Complement component 4 protein that in humans is encoded by the C4B gene. This gene encodes...

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Complement receptor 2

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Complement component 6

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Complement component 6 is a protein that in humans is encoded by the C6 gene. Complement component 6 is a protein involved in the complement system. It...

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C2

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Albert says that each C2 atom contains a thousand protein molecules. Complement component 2 Procyanidin C2, a plant phenolic compound Prodelphinidin C2, a plant...

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Classical complement pathway

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classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway...

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Complement factor B

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Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway...

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Acquired C1 esterase inhibitor deficiency

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proteins in the complement cascade are activated, including complement component 2 (C2), complement component 3 (C3), and complement component 4 (C4). When...

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Macular degeneration

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at location 10q26 Complement Factor B/Complement Component 2 (CFB/CC2) on chromosome 6 at 6p21.3 Polymorphisms in genes for complement system proteins:...

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Alternative complement pathway

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alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections...

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Complement membrane attack complex

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cells, leading to cell lysis and death. The MAC is composed of the complement components C5b, C6, C7, C8 and several C9 molecules. A number of proteins participate...

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List of autoimmune diseases

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(2022-07-07). "Insights Into the Pathogenesis of Bullous Pemphigoid: The Role of Complement-Independent Mechanisms". Frontiers in Immunology. 13. Frontiers Media...

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C8 complex

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Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC). A hereditary deficiency of C8 can...

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Complement receptor

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express complement receptors on their surface. All four complement receptors can bind to fragments of complement component 3 or complement component 4 coated...

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Complement deficiency

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Deficiencies of the terminal complement components increases susceptibility to infections by Neisseria. The cause of complement deficiency is genetics (though...

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Complement 3 deficiency

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Complement 3 deficiency is a genetic condition affecting complement component 3 (C3). People can suffer from either primary or secondary C3 deficiency...

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C4A

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Complement C4-A is a kind of the Complement component 4 protein that in humans is encoded by the C4A gene. This gene encodes the acidic form of complement...

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Lectin pathway

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residues on the surface of a pathogen, MASP-1 and MASP-2 are activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b. In f, two smaller...

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Phonetic complement

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A phonetic complement is a phonetic symbol used to disambiguate word characters (logograms) that have multiple readings, in mixed logographic-phonetic...

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