positive regulation of calcium ion transport into cytosol
vasoconstriction
response to progesterone
negative regulation of protein binding
regulation of peptidase activity
protein localization to plasma membrane raft
mammary gland development
vasculogenesis
negative regulation of pinocytosis
response to ischemia
angiogenesis
apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
cholesterol homeostasis
triglyceride metabolic process
negative regulation of canonical Wnt signaling pathway
calcium ion transport
negative regulation of cell population proliferation
cellular response to transforming growth factor beta stimulus
positive regulation of toll-like receptor 3 signaling pathway
regulation of cytosolic calcium ion concentration
regulation of smooth muscle contraction
vesicle organization
negative regulation of peptidyl-tyrosine autophosphorylation
regulation of cardiac muscle cell action potential involved in regulation of contraction
negative regulation of transforming growth factor beta receptor signaling pathway
protein localization to basolateral plasma membrane
receptor internalization involved in canonical Wnt signaling pathway
regulation of membrane repolarization during action potential
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein tyrosine kinase activity
regulation of entry of bacterium into host cell
negative regulation of MAP kinase activity
positive regulation of vasoconstriction
negative regulation of potassium ion transmembrane transport
lactation
receptor-mediated endocytosis of virus by host cell
regulation of blood coagulation
regulation of ventricular cardiac muscle cell action potential
protein homooligomerization
viral process
positive regulation of intrinsic apoptotic signaling pathway
negative regulation of receptor signaling pathway via JAK-STAT
mammary gland involution
calcium ion homeostasis
negative regulation of necroptotic process
regulation of the force of heart contraction
lipid storage
nitric oxide homeostasis
membrane depolarization
negative regulation of cytokine-mediated signaling pathway
cellular calcium ion homeostasis
negative regulation of transcription by RNA polymerase II
response to estrogen
response to calcium ion
regulation of fatty acid metabolic process
cellular response to exogenous dsRNA
negative regulation of MAPK cascade
regulation of ruffle assembly
positive regulation of protein binding
positive regulation of protein ubiquitination
negative regulation of anoikis
leukocyte migration
protein localization
positive regulation of cell adhesion molecule production
response to hypoxia
negative regulation of nitric-oxide synthase activity
response to bacterium
caveola assembly
cellular response to hyperoxia
cholesterol transport
cellular response to starvation
T cell costimulation
regulation of nitric-oxide synthase activity
receptor internalization
positive regulation of peptidase activity
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of endothelial cell proliferation
negative regulation of BMP signaling pathway
negative regulation of protein ubiquitination
cellular response to peptide hormone stimulus
positive regulation of gene expression
negative regulation of nitric oxide biosynthetic process
angiotensin-activated signaling pathway involved in heart process
protein complex oligomerization
negative regulation of peptidyl-serine phosphorylation
posttranscriptional regulation of gene expression
positive regulation of gap junction assembly
maintenance of protein location in cell
negative regulation of signal transduction
regulation of the force of heart contraction by chemical signal
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of heart rate by cardiac conduction
negative regulation of epithelial cell differentiation
skeletal muscle tissue development
beta-catenin destruction complex disassembly
positive regulation of catalytic activity
positive regulation of canonical Wnt signaling pathway
negative regulation of tyrosine phosphorylation of STAT protein
negative regulation of inward rectifier potassium channel activity
cell differentiation
positive regulation of cell migration
positive regulation of cold-induced thermogenesis
positive regulation of NF-kappaB transcription factor activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
857
12389
Ensembl
ENSG00000105974
ENSMUSG00000007655
UniProt
Q03135
P49817
RefSeq (mRNA)
NM_001753 NM_001172895 NM_001172896 NM_001172897
NM_001243064 NM_007616
RefSeq (protein)
NP_001166366 NP_001166367 NP_001166368 NP_001744
NP_001229993 NP_031642
Location (UCSC)
Chr 7: 116.52 – 116.56 Mb
Chr 6: 17.31 – 17.34 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000105974 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000007655 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (March 1999). "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors". Genomics. 56 (3): 355–6. doi:10.1006/geno.1998.5723. PMID 10087206.
Caveolin-1 is a protein that in humans is encoded by the CAV1 gene. The scaffolding protein encoded by this gene is the main component of the caveolae...
the proteins caveolin-1, caveolin-2, and caveolin-3, respectively. All three members are membrane proteins with similar structure. Caveolin forms oligomers...
discovered the clathrin coat molecule in 1976. Caveolin proteins like caveolin-1 (CAV1), caveolin-2 (CAV2), and caveolin-3 (CAV3), play significant roles in the...
possibly related to overexpression (hypomethylation) of caveolin1 and caveolin 2. Caveolin is, paradoxically, tumour-promoting in IBC. NF-κB pathway...
caveolins associate with lipid rafts and form oligomers (14-16 molecules). These oligomerized caveolins form the caveolae. The presence of caveolin leads...
direct interaction of eNOS with caveolin-1. The binding of calcium-activated calmodulin to eNOS displaces caveolin-1 and activates eNOS. However, more...
1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin1–annexin...
Caveolin-2 is a protein that in humans is encoded by the CAV2 gene. The protein encoded by this gene is a major component of the inner surface of caveolae...
a post-translational modification that enhances ER association with caveolin-1 to enable trafficking of ERs to the membrane or membrane caveolae. Other...
regulated positively by TSH [citation needed]. The phosphorylation of caveolin1 induced by hydrogen peroxide has been shown to be critical to the activation...
through modulation of adenylyl cyclase. It is also known to bind the caveolin1, a protein which regulates p21ras, PKC and growth response factors. There...
2009). "Amyloid beta-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes"...
gastric cancer cells. High amounts of GM3 also displayed a high amount of caveolin-1, a molecule which has been shown to inhibit ovarian cancer growth. In...
in most cases (heritable in some cases) Heritable (BMPR2, ALK1, SMAD9, caveolin1, KCNK3 mutations) Drug- and toxin-induced (e.g., methamphetamine, amphetamine...
promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways". Brain Research. 1585: 83–90. doi:10.1016/j.brainres...
the cell and entering it by endocytosis mediated by either clathrin or caveolin-1. HBV initially binds to heparin sulfate proteoglycan. The pre-S1 segment...
Caveolin-3 is a protein that in humans is encoded by the CAV3 gene. Alternative splicing has been identified for this locus, with inclusion or exclusion...
has been previously shown that caveolin-1-deficient mice show insulin resistance. MicroRNA-103/107 inhibition in caveolin-1-deficient mice had no effect...
Gap junction protein, alpha 1 has been shown to interact with: Cx37, Cx40, Cx45, MAPK7, Caveolin1, Tight junction protein 1 CSNK1D, and PTPmu (PTPRM)....