Membrane estrogen receptors (mERs) are a group of receptors which bind estrogen.[1][2] Unlike nuclear estrogen receptors, which mediate their effects via slower genomic mechanisms, mERs are cell surface receptors that rapidly alter cell signaling via modulation of intracellular signaling cascades.[3][4]
Nuclear estrogen receptors such as ERα and ERβ become mERs through palmitoylation, a post-translational modification that enhances ER association with caveolin-1 to enable trafficking of ERs to the membrane or membrane caveolae.[5][6] Other putative mERs include GPER (GPR30), GPRC6A, ER-X, ERx and Gq-mER.[3][7][8][9]
ERα/ERβ becoming mERs through trafficking to the membrane by caveolins, following palmitoylation.
^Soltysik K, Czekaj P (April 2013). "Membrane estrogen receptors - is it an alternative way of estrogen action?". Journal of Physiology and Pharmacology. 64 (2): 129–142. PMID 23756388.
^ abMicevych PE, Mermelstein PG (August 2008). "Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain". Molecular Neurobiology. 38 (1): 66–77. doi:10.1007/s12035-008-8034-z. PMC 2663000. PMID 18670908.
^Razandi M, Pedram A, Greene GL, Levin ER (February 1999). "Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells". Molecular Endocrinology. 13 (2): 307–319. doi:10.1210/mend.13.2.0239. PMID 9973260.
^Razandi M, Alton G, Pedram A, Ghonshani S, Webb P, Levin ER (March 2003). "Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane". Molecular and Cellular Biology. 23 (5): 1633–1646. doi:10.1128/MCB.23.5.1633-1646.2003. PMC 151696. PMID 12588983.
^Levin ER (December 2009). "Plasma membrane estrogen receptors". Trends in Endocrinology and Metabolism. 20 (10): 477–482. doi:10.1016/j.tem.2009.06.009. PMC 3589572. PMID 19783454.
Membraneestrogenreceptors (mERs) are a group of receptors which bind estrogen. Unlike nuclear estrogenreceptors, which mediate their effects via slower...
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PMID 15196329. Zivadinovic D, Gametchu B, Watson CS (2005). "Membraneestrogenreceptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation...
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PMID 17222505. Soltysik K, Czekaj P (April 2013). "Membraneestrogenreceptors - is it an alternative way of estrogen action?". Journal of Physiology and Pharmacology...
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