Global InformationAntagomir information
Antagomirs, also known as anti-miRs, are a class of chemically engineered oligonucleotides designed to silence endogenous microRNAs (also known as miRNAs or miRs).[1][2][3]
Antagomirs are a kind of antisense oligonucleotide, as their sequence is complementary to their specific miRNA target. Their structure has modifications so as to make them more resistant to degradation. These include 2'-methoxy groups on the ribose sugar, backbones with phosphorothioate bonds, and cholesterol conjugation on the 3' end.[4]
- ^ Yue J (July 2011). "miRNA and vascular cell movement". Adv. Drug Deliv. Rev. 63 (8): 616–22. doi:10.1016/j.addr.2011.01.001. PMC 3129380. PMID 21241758.
- ^ Krützfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M (December 2005). "Silencing of microRNAs in vivo with "antagomirs"". Nature. 438 (7068): 685–9. Bibcode:2005Natur.438..685K. doi:10.1038/nature04303. PMID 16258535. S2CID 4414240.
- ^ Czech MP (March 2006). "MicroRNAs as therapeutic targets". N. Engl. J. Med. 354 (11): 1194–5. doi:10.1056/NEJMcibr060065. PMID 16540623.
- ^ Ling, Hui; Calin, George A. (2014-01-01), Dellaire, Graham; Berman, Jason. N.; Arceci, Robert J. (eds.), "Chapter 25 - The Role of MicroRNAs and Ultraconserved Non-Coding RNAs in Cancer", Cancer Genomics, Boston: Academic Press, pp. 435–447, doi:10.1016/b978-0-12-396967-5.00025-6, ISBN 978-0-12-396967-5, retrieved 2022-09-11