Carbon disulfide hydrolase is an enzyme with a molecular mass of 23,576 Da. The enzyme is hexadecameric. It catalyzes the hydrolysis of carbon disulfide.[1]
Carbon disulfide occurs naturally in the mudpots of volcanic solfataras. It is a precursor to hydrogen sulfide, which is an electron donor. The hyperthermophilic Acidianus strain was found to convert CS2 into H2S and CO2.[1]
The enzyme is similar to that of carbonic anhydrases. The enzyme monomer of CS2 hydrolase displays a typical β-carbonic anhydrase fold and active site. Two of these monomers form a closely intertwined dimer with a central β-sheet capped by an α-helical domain. Four dimers form a square octameric ring through interactions of the long arms at the N and C termini. Similar ring structures have been seen in strains of carbonic anhydrases, however, in CS2 hydrolase is an enzyme consisting of two octameric rings form a hexadecamer by interlocking at right angles to each other. This results in the blocking of the entrance to the active site and the formation of a single 15-Å-long, highly hydrophobic tunnel that functions as a specificity filter. This provides a key difference between carbonic anhydrase and CS2 hydrolase. This tunnel determines the enzyme's substrate specificity for CS2, which is hydrophobic as well.
^ abSmeulders MJ, Barends TR, Pol A, Scherer A, Zandvoort MH, Udvarhelyi A, Khadem AF, Menzel A, Hermans J, Shoeman RL, Wessels HJ, van den Heuvel LP, Russ L, Schlichting I, Jetten MS, Op den Camp HJ (2011). "Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon". Nature. 478 (7369): 412–416. Bibcode:2011Natur.478..412S. doi:10.1038/nature10464. hdl:11858/00-001M-0000-0024-1F1A-F. PMID 22012399. S2CID 2580000.
and 25 Related for: Carbon disulfide hydrolase information
Carbondisulfidehydrolase is an enzyme with a molecular mass of 23,576 Da. The enzyme is hexadecameric. It catalyzes the hydrolysis of carbon disulfide...
Carbondisulfide (also spelled as carbon disulphide) is an inorganic compound with the chemical formula CS2 and structure S=C=S. It is also considered...
degradation enzymes. These enzymes are carbonic anhydrase, carbonicdisulfidehydrolase, nitrogenase, carbon monoxide, and RuBisCO. The enzymes listed...
is a cyclic ether, where the ether forms a three-atom ring: two atoms of carbon and one atom of oxygen. This triangular structure has substantial ring strain...
solution. Another important group of thermostable enzymes are glycoside hydrolases. These enzymes are responsible of the degradation of the major fraction...
the propeptide is required for enzyme activation, although bleomycin hydrolase is cytosolic in fungi and mammals. Papain-like cysteine proteinases are...
composed of six carbon atoms joined in a planar hexagonal ring with one hydrogen atom attached to each. Because it contains only carbon and hydrogen atoms...
transferases, hydrolases, lyases, isomerases, and ligases). Lysine carboxypeptidase belongs to class 3 which indicates that it is a hydrolase. Hydrolases use water...
proteases that digest proteins into amino acids, as well as glycoside hydrolases that digest polysaccharides into simple sugars known as monosaccharides...
cysteine residues in the peptide may be temporarily blocked from forming disulfide bonds with other cysteine residues, due to the size of a nearby glycan...
active site of some enzymes. Catalytic triads are most commonly found in hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases...
animals that forms part of the innate immune system. It is a glycoside hydrolase that catalyzes the following process: Hydrolysis of (1→4)-β-linkages between...
Da.[citation needed] β-Glucocerebrosidase is a member of the glycoside hydrolase family 30 and consists of three distinct domains (I-III). Three-dimensional...
structure is the link formed by covalent loops, closed by disulfide bridges. Three types of disulfide-based links were identified in proteins: two versions...
cellophane) from dissolving pulp. The most important solubilizing agent is carbondisulfide in the presence of alkali. Other agents include Schweizer's reagent...
widely distributed cellular enzyme, soluble epoxide hydrolase (sEH), also termed epoxide hydrolase 2. The EETs consequently function as transiently acting...
a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end. Some chemistry...
promoting the proliferation of cells. Epoxide hydrolase: 15-Deoxy-Δ12,14-PGJ2 inhibits soluble epoxide hydrolase 2 by forming adducts with its catalytic cysteine...
form a red-colored compound, rosocyanine. Curcumin incorporates a seven carbon linker and three major functional groups: an α,β-unsaturated β-diketone...
amino acids) constitute an extracellular PLA1 exhibiting triacylglycerol hydrolase activity. In contrast, a PLA1 enzyme that is considered more selective...
epimerase, which converts (−)-R-ibuprofen I-CoA to (+)-S-ibuprofen I-CoA; and hydrolase, which converts (+)-S-ibuprofen I-CoA to the S-enantiomer. In addition...
temperatures and use complex carbon sources for energy. As the temperature of compost heaps rises and the availability of simple carbon sources decreases, it...
determined in his lab. This structure revealed: AChE is a prototype of the α/β hydrolase fold; π-cation interactions play a key role in binding of acetylcholine...