Crystallographic structure of phospholipase A1. Red region denotes α helices, Green region denotes loops, and yellow region denotes β sheets.
Identifiers
EC no.
3.1.1.32
CAS no.
9043-29-2
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
phospholipase A1 member A
Identifiers
Symbol
PLA1A
NCBI gene
51365
HGNC
17661
OMIM
607460
RefSeq
NM_015900
UniProt
Q53H76
Other data
EC number
3.1.1.32
Locus
Chr. 3 q13.13-13.2
Search for
Structures
Swiss-model
Domains
InterPro
Phospholipase A1 (EC 3.1.1.32; systematic name: phosphatidylcholine 1-acylhydrolase) encoded by the PLA1A gene is a phospholipase enzyme which removes the 1-acyl group:[1]
phosphatidylcholine + H2O ⇌ 2-acylglycerophosphocholine + a carboxylate
It is an enzyme that resides in a class of enzymes called phospholipase that hydrolyze phospholipids into fatty acids.[2] There are four classes, separated according to the type of reaction they catalyze. In particular, phospholipase A1 (PLA1) specifically catalyzes the cleavage at the sn-1 position of phospholipids, forming a fatty acid and a lysophospholipid.[3][4]
Phospholipase A1 cleaves phospholipid at the sn-1 position forming a lysophospholipid and a fatty acid.
^Phospholipase+A1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^DeSilva NS, Quinn PA (1999). "Characterization of phospholipase A1, A2, C activity in Ureaplasma urealyticum membranes". Mol. Cell. Biochem. 201 (1–2): 159–67. doi:10.1023/A:1007082507407. PMID 10630635. S2CID 22101516.
^Richmond GS, Smith TK (2011). "Phospholipases A1". International Journal of Molecular Sciences. 12 (1): 588–612. doi:10.3390/ijms12010588. PMC 3039968. PMID 21340002.
^Scandella CJ, Kornberg A (November 1971). "A membrane-bound phospholipase A1 purified from Escherichia coli". Biochemistry. 10 (24): 4447–56. doi:10.1021/bi00800a015. PMID 4946924.
PhospholipaseA1 (EC 3.1.1.32; systematic name: phosphatidylcholine 1-acylhydrolase) encoded by the PLA1A gene is a phospholipase enzyme which removes...
they catalyze: Phospholipase A PhospholipaseA1 – cleaves the sn-1 acyl chain (where sn refers to stereospecific numbering). Phospholipase A2 – cleaves...
A2 phospholipases. Additional types of phospholipases include phospholipaseA1, phospholipase B, phospholipase C, and phospholipase D. Phospholipases A2...
Phospholipase A can refer to: PhospholipaseA1Phospholipase A2 Outer membrane phospholipaseA1 An enzyme that displays both phospholipaseA1 and phospholipase...
Outer membrane phospholipaseA1 (OMPLA) is an acyl hydrolase with a broad substrate specificity (EC:3.1.1.32.) from the bacterial outer membrane. It has...
"p-l-a", or "plas" on Wikipedia. Pla (disambiguation) PhospholipaseA1 (PLA1) Phospholipase A2 (PLA2) All pages with titles beginning with PLA All pages...
binding sites with prothrombin and also to inhibit the activity of phospholipaseA1. These properties have been found by in vitro experiments. Antibodies...
is to increase the synthesis and function of annexin A1. Annexin A1 both suppresses phospholipase A2, thereby blocking eicosanoid production, and inhibits...
porins (n=18,S=22) Nucleoside-specific porin (n=12,S=16) Outer membrane phospholipaseA1(n=12,S=16) TonB-dependent receptors and their plug domain. They are...
Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene. The phospholipase A2 enzyme family, including PLA2G4D, catalyze...
Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. This gene encodes a member of the cytosolic phospholipase A2 group...
1983). "Effects of the serine protease inhibitors FOY and FOY 305 on phospholipaseA1 (EC 3.1.1.32) activity in rat - liver lysosomes". Pharmacological Research...
BM, Kunze H (January 1992). "Annexin II inhibits calcium-dependent phospholipaseA1 and lysophospholipase but not triacyl glycerol lipase activities of...
triphosphate/diacylglycerol concentration is caused by an activation of phospholipase C, whereas the elevated levels of arachidonic acid are mediated by DAG...
Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene. GRCh38: Ensembl release 89: ENSG00000105499 – Ensembl, May...
Group XVI phospholipase A2 also commonly known as adipocyte phospholipase A2 (AdPLA) is an enzyme that in humans is encoded by the PLA2G16 gene. This...
phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipaseA1. Overexpression of this protein has been shown to cause disorganization...
Phospholipase A2, group IVB (cytosolic), also known as PLA2G4B, is a human gene. GRCh38: Ensembl release 89: ENSG00000168970 – Ensembl, May 2017 "Human...
containing 3 (ABHD3; alternative names: lung alpha/beta hydrolase 3, phospholipase ABHD3) is a single pass type II membrane member of the serine hydrolase...
PMID 15890616. Akesson B (May 1975). "Work in progress. Occurence [sic] of phospholipaseA1 and A2 in human decidua". Prostaglandins. 9 (5): 667–673. doi:10...
Wada, Ikuo; Yamashita, Atsushi (July 2021). "Phosphorylation of human phospholipaseA1 DDHD1 at newly identified phosphosites affects its subcellular localization"...
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