Ability of a substance to resist changes in structure under high temperatures
Crystal structure of β-glucosidase from Thermotoga neapolitana (PDB: 5IDI). Thermostable protein, active at 80°C and with unfolding temperature of 101°C.[1]
In materials science and molecular biology, thermostability is the ability of a substance to resist irreversible change in its chemical or physical structure, often by resisting decomposition or polymerization, at a high relative temperature.
Thermostable materials may be used industrially as fire retardants. A thermostable plastic, an uncommon and unconventional term, is likely to refer to a thermosetting plastic that cannot be reshaped when heated, than to a thermoplastic that can be remelted and recast.
Thermostability is also a property of some proteins. To be a thermostable protein means to be resistant to changes in protein structure due to applied heat.
^Kulkarni TS, Khan S, Villagomez R, Mahmood T, Lindahl S, Logan DT, et al. (May 2017). "Crystal structure of β-glucosidase 1A from Thermotoga neapolitana and comparison of active site mutants for hydrolysis of flavonoid glucosides". Proteins. 85 (5): 872–884. doi:10.1002/prot.25256. PMID 28142197. S2CID 27832389.
particular protein is responsible for its thermostability. Another type of force that is responsible for thermostability of a protein is the electrostatic interactions...
introducing Taq polymerase for PCR. The thermostability of Taq polymerase obliviated the need to add a non-thermostable DNA polymerase to the reaction after...
with proof-reading ability but a lower optimal temperature and low thermostability. Versions of the polymerase without the 5'-3' exonuclease domain has...
Protein tertiary structure is the three-dimensional shape of a protein. The tertiary structure will have a single polypeptide chain "backbone" with one...
in. For fluorescence-detection size-exclusion chromatography-based thermostability assay (FSEC-TS) the samples are heated in the same manner as in FastPP...
their applications in DNA replication techniques, such as PCR, where thermostable enzymes are necessary for proper DNA replication. Enzyme function at...
rings attached to their lipids that have been shown to increase the thermostability of the membrane. While all of the previously mentioned adaptations...
Kadeppagari, Ravi-Kumar (2012-04-23). "Evidence for the improvement of thermostability of the maltogenic α-amylase ofAspergillus nigerby negative pressure"...
oligonucleotides that are a complementary sequence to the target DNA region) and a thermostable DNA polymerase. In the first step of PCR, the two strands of the DNA...
increases their glass transition temperature, melting temperature, thermostability, chemical stability, and solvent resistance. Polyesters can also be...
these harsh conditions. These enzymes have found many uses. For example, thermostable DNA polymerases, such as the Pfu DNA polymerase from Pyrococcus furiosus...
Food and Drug Administration. Wilding, Kristen (25 November 2019). "Thermostable lyoprotectant-enhanced cell-free protein synthesis for on-demand endotoxin-free...
polymerizes partner strands in each direction from these primers using a thermostable DNA polymerase. Repeating this process through multiple cycles amplifies...
LNP formulations or mRNA secondary structures could account for the thermostability differences [between Moderna and BioNtech], many experts suspect both...
Bacillus licheniformis or Bacillus subtilis (strain MN-385), which are more thermostable than the originally used enzymes. Starting in 1982, pullulanases from...
macromolecules, which he characterized as polymers. Due to problems with thermostability, POM was not commercialized at that time. Circa 1952, research chemists...
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