In enzymology, a carbamate kinase (EC 2.7.2.2) is an enzyme that catalyzes the chemical reaction
ATP + NH3 + CO2 ADP + carbamoyl phosphate
The 3 substrates of this enzyme are ATP, NH3, and CO2, whereas its two products are ADP and carbamoyl phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:carbamate phosphotransferase. Other names in common use include CKase, carbamoyl phosphokinase, and carbamyl phosphokinase. This enzyme participates in 4 metabolic pathways: purine metabolism, glutamate metabolism, arginine and proline metabolism, and nitrogen metabolism.
In enzymology, a carbamatekinase (EC 2.7.2.2) is an enzyme that catalyzes the chemical reaction ATP + NH3 + CO2 ⇌ {\displaystyle \rightleftharpoons }...
industry, both are now suspected carcinogens. Benzyl carbamate is also known. The enzyme class carbamatekinase, involved in several metabolic pathways of living...
arginine deaminase (ADI), ornithine carbamoyltransferase (OTC), and carbamatekinase (CK). A fourth protein located at the cell membrane acts as transporter...
"Classification and Uses of Organophosphates and Carbamates". In Gupta RC (ed.). Toxicology of Organophosphate and Carbamate Compounds. Amsterdam: Elsevier Academic...
carbon dioxide molecule (CO2) to a lysine in the active site (forming a carbamate). Mg2+ operates by driving deprotonation of the Lys210 residue, causing...
its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation...
detected by an FDA-approved test. Encorafenib acts as an ATP-competitive RAF kinase inhibitor, decreasing ERK phosphorylation and down-regulation of CyclinD1...
in the 1940s as a cholinesterase inhibitor insecticide. Propoxur is a carbamate insecticide that was introduced by Bayer in 1959. In 1994, Bayer AG purchased...
tropomyosin receptor kinase B (TrkB), activation of the mammalian target of rapamycin (mTOR) pathway, deactivation of glycogen synthase kinase 3 (GSK-3), and...
residues enters the binding site, near the "toogle-switch" residue Trp6.48. Carbamate insecticides target human melatonin receptors. Despite its structural...
TAAR1, it triggers transporter phosphorylation via protein kinase A (PKA) and protein kinase C (PKC) signaling, ultimately resulting in the internalization...
found manipulating the level of nicotine in the brain along with the MAP kinase, another signaling receptor, to cause cell death. Another chemical in the...
which in turn inhibits cAMP synthesis leading to reduced PKA (Protein Kinase A) activation. This results in less calcium influx to cardiac myocytes through...
thus be used to kill tumor cells. Latrunculin A and its 17-O-[N-(benzyl)carbamate ( suppress hypoxia-induced HIF-1 activation in T47D breast tumor cells...
monophosphate (cAMP) as a result of interference with activation of protein kinase A (PKA), a cAMP dependent protein. Other possible pathways include interference...
through protein kinase A (PKA) and protein kinase C (PKC) signaling, causes DAT phosphorylation. Phosphorylation by either protein kinase can result in...
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