guanine nucleotide binding protein (G protein), q polypeptide
Identifiers
Symbol
GNAQ
NCBI gene
2776
HGNC
4390
OMIM
600998
RefSeq
NM_002072
UniProt
P50148
Other data
Locus
Chr. 9 q21
Search for
Structures
Swiss-model
Domains
InterPro
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Identifiers
Symbol
GNA11
NCBI gene
2767
HGNC
4379
OMIM
139313
RefSeq
NM_002067
UniProt
P29992
Other data
Locus
Chr. 19 p13.3
Search for
Structures
Swiss-model
Domains
InterPro
guanine nucleotide binding protein (G protein), alpha 14
Identifiers
Symbol
GNA14
NCBI gene
9630
HGNC
4382
OMIM
604397
RefSeq
NM_004297
UniProt
O95837
Other data
Locus
Chr. 9 q21
Search for
Structures
Swiss-model
Domains
InterPro
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Identifiers
Symbol
GNA15
NCBI gene
2769
HGNC
4383
OMIM
139314
RefSeq
NM_002068
UniProt
P30679
Other data
Locus
Chr. 19 p13.3
Search for
Structures
Swiss-model
Domains
InterPro
Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be referred to as Gq alpha, Gαq, or Gqα.
Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. PLC-β in turn hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium into the cytoplasm, while DAG acts as a second messenger that activates protein kinase C (PKC).
Gq protein alphasubunit is a family of heterotrimeric G protein alphasubunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15...
Gi protein alphasubunit is a family of heterotrimeric G protein alphasubunits. This family is also commonly called the Gi/o (Gi /Go ) family or Gi/o/z/t...
The Gs alphasubunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase...
G(q) subunitalpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11 (its paralogue), it functions as a Gqalphasubunit. Guanine...
class of complexes is made up of alpha (Gα), beta (Gβ) and gamma (Gγ) subunits. In addition, the beta and gamma subunits can form a stable dimeric complex...
and activate, i.e. those containing the Gs alphasubunit, Gi alphasubunit, Gqalphasubunit and/or G12 subunit; and f) signaling pathways which they regulate...
family, specifically the Gi/o alphasubunit GPCRs, although melatonin receptor 1 also exhibits coupling with Gqalphasubunit. Furthermore, melatonin functions...
the G-protein by exchanging the GDP on the alphasubunit to GTP. The binding of GTP to the alphasubunit results in a structural change and its dissociation...
nucleotide-binding protein subunitalpha-14 is a protein that in humans is encoded by the GNA14 gene. G14α is a member of the Gqalphasubunit family, and functions...
nucleotide-binding protein subunitalpha-15 is a protein that in humans is encoded by the GNA15 gene. G15α is a member of the Gqalphasubunit family, and functions...
phospholipase C in response to either receptor tyrosine kinase or Gqalphasubunit-G protein-coupled receptor signaling. Soluble inositol trisphosphate...
coupling and activating G protein coupled receptors coupled to the Gqalphasubunit, activating the IP3/DAG pathway to increase Ca2+. For GHRH, however...
Gq family α-subunits, but do not accelerate their GTP hydrolysis. Instead, GRKs appear to reduce Gq signaling by sequestering the active α-subunits away...
receptor is a G-protein-coupled receptor with the Gs alphasubunit as its main signaling protein. The subunit dissociates from the receptor when activated, subsequently...
releasing hormones binding to G protein coupled receptors coupled to the Gqalphasubunit, activating the IP3/DAG pathway to increase Ca2+. Examples of this...
Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic...
1998). "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit". The Journal of Biological Chemistry...
bioinformatic techniques. G proteins contain an alpha-subunit that is critical to the functioning of receptors. These subunits can take a number of forms. There are...
the Gqalphasubunit. When bound to one of its ligands, OXGR1 activates Gqalphasubunit-regulated cellular pathways (see Functions of the Gqalpha pathways)...
diphosphate) molecule on its alphasubunit for a GTP (guanosine triphosphate) molecule. Once this exchange takes place, the alphasubunit of the G-protein transducer...
the Gqalphasubunit and/or Ga subunit of its coupled G protein, depending or the cell type. Acting through these G proteins and their subunits, ligand-bound...