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Gq alpha subunit information


guanine nucleotide binding protein (G protein), q polypeptide
Identifiers
SymbolGNAQ
NCBI gene2776
HGNC4390
OMIM600998
RefSeqNM_002072
UniProtP50148
Other data
LocusChr. 9 q21
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StructuresSwiss-model
DomainsInterPro
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Identifiers
SymbolGNA11
NCBI gene2767
HGNC4379
OMIM139313
RefSeqNM_002067
UniProtP29992
Other data
LocusChr. 19 p13.3
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StructuresSwiss-model
DomainsInterPro
guanine nucleotide binding protein (G protein), alpha 14
Identifiers
SymbolGNA14
NCBI gene9630
HGNC4382
OMIM604397
RefSeqNM_004297
UniProtO95837
Other data
LocusChr. 9 q21
Search for
StructuresSwiss-model
DomainsInterPro
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Identifiers
SymbolGNA15
NCBI gene2769
HGNC4383
OMIM139314
RefSeqNM_002068
UniProtP30679
Other data
LocusChr. 19 p13.3
Search for
StructuresSwiss-model
DomainsInterPro

Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be referred to as Gq alpha, Gαq, or Gqα. Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. PLC-β in turn hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium into the cytoplasm, while DAG acts as a second messenger that activates protein kinase C (PKC).

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Gq alpha subunit

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Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15...

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Alpha subunit

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Alpha subunits (α) refers to several protein subunits, e.g.: G proteins Gi alpha subunit Gs alpha subunit Gq alpha subunit The pore-forming loop of ion...

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Gi alpha subunit

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Gi protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gi/o (Gi /Go ) family or Gi/o/z/t...

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Gs alpha subunit

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The Gs alpha subunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase...

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GNAQ

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G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11 (its paralogue), it functions as a Gq alpha subunit. Guanine...

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G protein

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class of complexes is made up of alpha (Gα), beta (Gβ) and gamma (Gγ) subunits. In addition, the beta and gamma subunits can form a stable dimeric complex...

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GNA11

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subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit. Gq...

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Prostaglandin receptor

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and activate, i.e. those containing the Gs alpha subunit, Gi alpha subunit, Gq alpha subunit and/or G12 subunit; and f) signaling pathways which they regulate...

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Melatonin

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family, specifically the Gi/o alpha subunit GPCRs, although melatonin receptor 1 also exhibits coupling with Gq alpha subunit. Furthermore, melatonin functions...

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Heterotrimeric G protein

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the G-protein by exchanging the GDP on the alpha subunit to GTP. The binding of GTP to the alpha subunit results in a structural change and its dissociation...

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GNA14

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nucleotide-binding protein subunit alpha-14 is a protein that in humans is encoded by the GNA14 gene. G14α is a member of the Gq alpha subunit family, and functions...

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GNA15

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nucleotide-binding protein subunit alpha-15 is a protein that in humans is encoded by the GNA15 gene. G15α is a member of the Gq alpha subunit family, and functions...

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Inositol phosphate

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phospholipase C in response to either receptor tyrosine kinase or Gq alpha subunit-G protein-coupled receptor signaling. Soluble inositol trisphosphate...

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Releasing and inhibiting hormones

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coupling and activating G protein coupled receptors coupled to the Gq alpha subunit, activating the IP3/DAG pathway to increase Ca2+. For GHRH, however...

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Regulator of G protein signaling

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Gq family α-subunits, but do not accelerate their GTP hydrolysis. Instead, GRKs appear to reduce Gq signaling by sequestering the active α-subunits away...

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Adrenergic neuron blockers

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receptor is a G-protein-coupled receptor with the Gs alpha subunit as its main signaling protein. The subunit dissociates from the receptor when activated, subsequently...

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Index of biophysics articles

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receptor, alpha 1 Glycophosphatidylinositol Godfrey Hounsfield Gopinath Kartha Gq alpha subunit Gray's paradox Ground reaction force Gs alpha subunit Gunther...

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Vesicle fusion

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releasing hormones binding to G protein coupled receptors coupled to the Gq alpha subunit, activating the IP3/DAG pathway to increase Ca2+. Examples of this...

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Alpha blocker

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Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic...

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AMPA receptor

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1998). "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit". The Journal of Biological Chemistry...

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Muscarinic acetylcholine receptor

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bioinformatic techniques. G proteins contain an alpha-subunit that is critical to the functioning of receptors. These subunits can take a number of forms. There are...

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OXGR1

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the Gq alpha subunit. When bound to one of its ligands, OXGR1 activates Gq alpha subunit-regulated cellular pathways (see Functions of the Gq alpha pathways)...

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Prostacyclin receptor

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A-dependent cell signaling pathways (see PKA); b) Gq alpha subunit-Gβγ complexes which release Gq that then stimulates other cell signaling pathways...

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Second messenger system

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diphosphate) molecule on its alpha subunit for a GTP (guanosine triphosphate) molecule. Once this exchange takes place, the alpha subunit of the G-protein transducer...

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Cysteinyl leukotriene receptor 2

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the Gq alpha subunit and/or Ga subunit of its coupled G protein, depending or the cell type. Acting through these G proteins and their subunits, ligand-bound...

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