Global Information Lookup Global Information

Noscapine information


Noscapine
Clinical data
Other namesNarcotine
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • Contraindicated
ATC code
  • R05DA07 (WHO)
Legal status
Legal status
  • AU: S2 (Pharmacy medicine)
  • EU: BE, SE: otc (over-the-counter)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability~30%
Elimination half-life1.5 to 4 h (mean 2.5)
Identifiers
IUPAC name
  • (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl]-1(3H)-isobenzofuranone
CAS Number
  • 128-62-1 checkY
PubChem CID
  • 275196
ChemSpider
  • 242139 checkY
UNII
  • 8V32U4AOQU
KEGG
  • D01036 checkY
ChEBI
  • CHEBI:73237 ☒N
ChEMBL
  • ChEMBL364713 checkY
CompTox Dashboard (EPA)
  • DTXSID4023385 Edit this at Wikidata
ECHA InfoCard100.004.455 Edit this at Wikidata
Chemical and physical data
FormulaC22H23NO7
Molar mass413.426 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=C2O[C@@H](c1ccc(OC)c(OC)c12)[C@@H]5N(C)CCc4c5c(OC)c3OCOc3c4
InChI
  • InChI=1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1 checkY
  • Key:AKNNEGZIBPJZJG-MSOLQXFVSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid, of the phthalideisoquinoline structural subgroup, which has been isolated from numerous species of the family Papaveraceae (poppy family). It lacks significant hypnotic, euphoric, or analgesic effects affording it with very low addictive potential.[1] This agent is primarily used for its antitussive (cough-suppressing) effects.

  1. ^ Altinoz MA, Topcu G, Hacimuftuoglu A, Ozpinar A, Ozpinar A, Hacker E, Elmaci İ (August 2019). "Noscapine, a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma". Neurochemical Research. 44 (8): 1796–1806. doi:10.1007/s11064-019-02837-x. PMID 31292803. S2CID 195873326.

and 29 Related for: Noscapine information

Request time (Page generated in 0.5552 seconds.)

Noscapine

Last Update:

Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid, of the phthalideisoquinoline...

Word Count : 2869

Butamirate

Last Update:

one cyclopentyl in the same place.) Oxeladin Pentoxyverine Cough syrup Noscapine Codeine; Pholcodine Dextromethorphan; Dimemorfan Racemorphan; Dextrorphan;...

Word Count : 230

Papaveretum

Last Update:

papaveretum also contained noscapine, though this component was removed from the BP formulation due to the genotoxic potential of noscapine. Lewis KE (2002). "Analgesic...

Word Count : 201

Laudanum

Last Update:

However, the modern drug is often processed to remove all or most of the noscapine (also called narcotine) present as this is a strong emetic and does not...

Word Count : 6082

Papaverine

Last Update:

Pantopon) and others, along with morphine, codeine, and in some cases noscapine and others in a percentage similar to that in opium, or modified for a...

Word Count : 1729

Opium

Last Update:

codeine and thebaine, and non-analgesic alkaloids such as papaverine and noscapine. The traditional, labor-intensive method of obtaining the latex is to...

Word Count : 14990

Papaver somniferum

Last Update:

from (S) -reticuline morphine can be formed through the morphinan route, noscapine through the path of the noscapina or berberina. The poppy genome contains...

Word Count : 5949

Spasmofen

Last Update:

morphine, also an opioid papaverine, an opium alkaloid antispasmodic drug noscapine Spasmofen product information from FASS (drug formulary). Last reviewed...

Word Count : 88

Canadine

Last Update:

oxidase. It is also an intermediate in the complex biosynthesis of noscapine, which is likewise a benzylisoquinoline alkaloid, but of the phthalideisoquinoline...

Word Count : 633

Latex

Last Update:

source of medically useful non-analgesic alkaloids, such as papaverine and noscapine.[citation needed] Latex is used in many types of clothing. Worn on the...

Word Count : 1852

Promethazine

Last Update:

as Dhasedyl DM; with glutamic acid as Psico-Soma, and Psicosoma; with noscapine as Tussisedal; and with chlorpromazine and phenobarbital as Vegetamin...

Word Count : 2670

Cocaine

Last Update:

Methamphetamine Methoxetamine Methylphenidate Nepinalone Neuropeptide Y Noscapine OPC-14523 Opipramol Pentazocine Pentoxyverine (carbetapentane) PRE-084...

Word Count : 17673

MDMA

Last Update:

Tifluadom U-50488 U-69,593 Xorphanol Oneirogens Calea zacatechichi Silene capensis Galantamine Others Glaucine Isoaminile Noscapine Prenoxdiazine Pukateine...

Word Count : 15730

Racemorphan

Last Update:

tartrate (0.632). Levallorphan Methorphan Morphinan Cyclorphan Cough syrup Noscapine Codeine; Pholcodine Dextromethorphan; Dimemorfan Dextrorphan; Levorphanol...

Word Count : 194

Legal opium production in India

Last Update:

alkaloid products like Codeine phosphate, Thebaine, Morphine sulphate, Noscapine that are sold for pharmaceutical operations. But manufacturing of drugs...

Word Count : 1521

Dextrorphan

Last Update:

before observing it in in vitro. Cough syrup Racemorphan; Levorphanol Noscapine Codeine; Pholcodine Dextromethorphan; Dimemorfan Butamirate Pentoxyverine...

Word Count : 649

Ketamine

Last Update:

Methamphetamine Methoxetamine Methylphenidate Nepinalone Neuropeptide Y Noscapine OPC-14523 Opipramol Pentazocine Pentoxyverine (carbetapentane) PRE-084...

Word Count : 11363

LSD

Last Update:

Tifluadom U-50488 U-69,593 Xorphanol Oneirogens Calea zacatechichi Silene capensis Galantamine Others Glaucine Isoaminile Noscapine Prenoxdiazine Pukateine...

Word Count : 16488

Benzylisoquinoline

Last Update:

class is exemplified in part by the following compounds: papaverine, noscapine, codeine, morphine, apomorphine, berberine, tubocurarine. (S)-Norcoclaurine...

Word Count : 398

Methamphetamine

Last Update:

Methamphetamine Methoxetamine Methylphenidate Nepinalone Neuropeptide Y Noscapine OPC-14523 Opipramol Pentazocine Pentoxyverine (carbetapentane) PRE-084...

Word Count : 14825

Opioid

Last Update:

poppy, primarily morphine, codeine, and thebaine, but not papaverine and noscapine which have a different mechanism of action Esters of morphine opiates:...

Word Count : 19665

Cloperastine

Last Update:

piperidine (5) completes the synthesis of Cloperastine (6). Cough syrup Noscapine Codeine; Pholcodine Dextromethorphan; Dimemorfan Racemorphan; Dextrorphan;...

Word Count : 644

Saffron

Last Update:

Methamphetamine Methoxetamine Methylphenidate Nepinalone Neuropeptide Y Noscapine OPC-14523 Opipramol Pentazocine Pentoxyverine (carbetapentane) PRE-084...

Word Count : 7887

Salvia divinorum

Last Update:

Tifluadom U-50488 U-69,593 Xorphanol Oneirogens Calea zacatechichi Silene capensis Galantamine Others Glaucine Isoaminile Noscapine Prenoxdiazine Pukateine...

Word Count : 11775

Atropine

Last Update:

Tifluadom U-50488 U-69,593 Xorphanol Oneirogens Calea zacatechichi Silene capensis Galantamine Others Glaucine Isoaminile Noscapine Prenoxdiazine Pukateine...

Word Count : 3624

Pantopon

Last Update:

mixing 20 parts morphine HCl, 5 parts codeine, 6 parts thebaine, 8 parts noscapine, 2 parts narcotine, 6 parts miscellaneous alkaloids hydrochlorides. Pantopon...

Word Count : 386

Narcotoline

Last Update:

an opiate alkaloid chemically related to noscapine. It binds to the same receptors in the brain as noscapine to act as an antitussive, and has also been...

Word Count : 171

Psilocybin mushroom

Last Update:

Tifluadom U-50488 U-69,593 Xorphanol Oneirogens Calea zacatechichi Silene capensis Galantamine Others Glaucine Isoaminile Noscapine Prenoxdiazine Pukateine...

Word Count : 4402

Nitrous oxide

Last Update:

Tifluadom U-50488 U-69,593 Xorphanol Oneirogens Calea zacatechichi Silene capensis Galantamine Others Glaucine Isoaminile Noscapine Prenoxdiazine Pukateine...

Word Count : 10073

PDF Search Engine © AllGlobal.net