positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cAMP-mediated signaling
regulation of cell population proliferation
immune response
signal transduction
defense response
inflammatory response
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway
neutrophil chemotaxis
leukocyte chemotaxis
cellular response to lipopolysaccharide
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6373
n/a
Ensembl
ENSG00000169248
n/a
UniProt
O14625
n/a
RefSeq (mRNA)
NM_005409 NM_001302123
n/a
RefSeq (protein)
NP_001289052 NP_005400
n/a
Location (UCSC)
Chr 4: 76.03 – 76.04 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.[3]
C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.[4]
Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.[5] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.[4][6] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.[7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000169248 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abCole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (June 1998). "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3". The Journal of Experimental Medicine. 187 (12): 2009–21. doi:10.1084/jem.187.12.2009. PMC 2212354. PMID 9625760.
^Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (September 1996). "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha". The Journal of Biological Chemistry. 271 (37): 22878–84. doi:10.1074/jbc.271.37.22878. PMID 8798467.
^Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (May 1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". The Journal of Investigative Dermatology. 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762.
^Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)". Cytogenetics and Cell Genetics. 81 (3–4): 271–2. doi:10.1159/000015043. PMID 9730616. S2CID 46846304.
^O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.
C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene. C-X-C motif chemokine 11 is a small cytokine belonging to...
(MIG), CXCL10 (IP-10), and CXCL11 (I-TAC) whereas CXCR3-B can also bind to CXCL4 in addition to CXCL9, CXCL10, and CXCL11. CXCR3 is expressed primarily...
chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic...
of inflammation where the IFN-y inducible chemokines CXCL9, CXCL10 and CXCL11 are secreted. Mast cells: on their surface express several receptors for...
through chemokines such as CCL2, CCL4, CCL5, CXCL8, CXCL9, CXCL10, and CXCL11. Along with dendritic cells, macrophages help activate natural killer (NK)...
the structures of CXCL10 are 1lv9, 1o7y, and 1o80. CXCL9, CXCL10 and CXCL11 have proven to be valid biomarkers for the development of heart failure...
receptor type 3, encoded by CXCR3 gene; receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human...
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