negative regulation of NF-kappaB transcription factor activity
positive regulation of fat cell differentiation
immune response
regulation of calcium-mediated signaling
signal transduction
negative regulation of interleukin-12 production
chemokine-mediated signaling pathway
complement receptor mediated signaling pathway
inflammatory response
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1240
14747
Ensembl
ENSG00000174600
ENSMUSG00000042190
UniProt
Q99788
P97468
RefSeq (mRNA)
NM_004072 NM_001142343 NM_001142344 NM_001142345
NM_008153 NM_001359060
RefSeq (protein)
NP_001135815 NP_001135816 NP_001135817 NP_004063
NP_032179 NP_001345989
Location (UCSC)
Chr 12: 108.29 – 108.34 Mb
Chr 5: 113.75 – 113.79 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Chemokine like receptor 1 also known as ChemR23 (Chemerin Receptor 23) is a protein that in humans is encoded by the CMKLR1 gene.[5][6] Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin[7] and the omega-3 fatty acid eicosapentaenoic acid-derived specialized pro-resolving molecule, resolvin E1 (see Specialized proresolving mediators#EPA-derived resolvins (i.e. RvE)).[8] The murine receptor that shares almost 80% homology with the human receptor, is called Dez.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000174600 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000042190 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: CMKLR1 chemokine-like receptor 1".
^Gantz I, Konda Y, Yang YK, Miller DE, Dierick HA, Yamada T (1996). "Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors". Cytogenetics and Cell Genetics. 74 (4): 286–90. doi:10.1159/000134436. PMID 8976386.
^Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, Brézillon S, Tyldesley R, Blanpain C, Detheux M, Mantovani A, Sozzani S, Vassart G, Parmentier M, Communi D (October 2003). "Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids". The Journal of Experimental Medicine. 198 (7): 977–85. doi:10.1084/jem.20030382. PMC 2194212. PMID 14530373.
^Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN (March 2005). "Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1". The Journal of Experimental Medicine. 201 (5): 713–22. doi:10.1084/jem.20042031. PMC 2212834. PMID 15753205.
^Methner A, Hermey G, Schinke B, Hermans-Borgmeyer I (April 1997). "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development". Biochemical and Biophysical Research Communications. 233 (2): 336–42. doi:10.1006/bbrc.1997.6455. PMID 9144535.
ChemR23 (Chemerin Receptor 23) is a protein that in humans is encoded by the CMKLR1 gene. Chemokine receptor-like 1 is a G protein-coupled receptor for the...
chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1 (also known as ChemR23). Chemerin is a 14 kDa protein secreted in an inactive...
other receptors located on the neurons or nearby microglia or astrocytes. CMKLR1, GPR32, FPR2, and NMDA receptors have been proposed to be the receptors...
analog of RvE1 are full activators while RvE2 is a partial activator of the CMKLR1 receptor. All of these receptors activate their parent cells through standard...
functions as a receptor for chemerin. Other receptors for chemerin include CMKLR1 and CCRL2. ENSG00000283448 GRCh38: Ensembl release 89: ENSG00000183671,...
Global Information
