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Resolvin D2 (RvD2)
Resolvins are specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as from two isomers of docosapentaenoic acid (DPA), one omega-3 and one omega-6 fatty acid. As autacoids similar to hormones acting on local tissues, resolvins are under preliminary research for their involvement in promoting restoration of normal cellular function following the inflammation that occurs after tissue injury.[1][2] Resolvins belong to a class of polyunsaturated fatty acid (PUFA) metabolites termed specialized proresolving mediators (SPMs).[3][4]
^Moro, K; Nagahashi, M; Ramanathan, R; Takabe, K; Wakai, T (2016). "Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer". World Journal of Clinical Cases. 4 (7): 155–164. doi:10.12998/wjcc.v4.i7.155. PMC 4945585. PMID 27458590.
^Balta, M. G; Loos, B. G; Nicu, E. A (2017). "Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1". Frontiers in Immunology. 8: 1682. doi:10.3389/fimmu.2017.01682. PMC 5735081. PMID 29312286.
^Cite error: The named reference ReferenceA was invoked but never defined (see the help page).
^Duvall, M. G.; Levy, B. D. (2015). "DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation". European Journal of Pharmacology. 785: 144–155. doi:10.1016/j.ejphar.2015.11.001. PMC 4854800. PMID 26546247.
but also many other agents including the docosanoids resolvin D1, resolvin D2, and 17R-resolvin D1 (see specialized pro-resolving mediators; oligopeptides...
prominently the prostaglandins, thromboxanes, leukotrienes, lipoxins, resolvins, and eoxins. For each subfamily, there is the potential to have at least...
cyclooxygenase 2-derived resolvin E series metabolites of the omega 3 fatty acid, eicosapentaenoic acid; certain 15-lipoxygenase-derived resolvin D series metabolites...
dramatically reduce inflammation through conversion within the body to resolvins, with beneficial effects for the cardiovascular system and arthritis....
anti-inflammatory specialized proresolving mediators, i.e. lipoxins, resolvins, maresins, and neuroprotectins Downregulation of pro-inflammatory molecules...
Publications - Announcements - part of Publications: Development of New Resolvin D1 Analogues for Osteoarthritis Therapy: Acellular and Computational Approaches...
eicosapentaenoic acid which is metabolized to the Resolvin E's; docosahexaenoic acid which is metabolized to the resolvin D's, maresins, and neuroprotectins; and...
series resolvins (see Resolvin § Resolvin Es) and of docosahexaenoic acid to D series resolvins (see Resolvin § Resolvin Ds). These resolvins are also...
proresolving mediators such as the aspirin-triggered lipoxins, aspirin-triggered resolvins, and aspirin-triggered maresins. These mediators possess potent anti-inflammatory...
NAGly was not shown to be a GPR18 agonist in rat sympathetic neurons. Resolvin D2 (RvD2), a member of the specialized proresolving mediators (SPM) class...
associated with ACE inhibitor-induced cough in humans. Resolvin E1 (RvE1), RvD2 (see resolvins), neuroprotectin D1 (NPD1), and maresin 1 (Mar1) are metabolites...
four resolvins of T series and three of D series (RvT1, RvT2, RvT3, RvT4, RvD1n-3, RvD2n-3, and RvD5n-3 (do not confuse with D series resolvins derived...
eicosanoids. Anti-inflammatory eicosanoids include lipoxins, epi-lipoxins, and resolvins, which cause release of growth hormones.[citation needed] Health Paul...
certain resolvins of the D series (i.e. RvD1, RvD2, RvD3, RvD4, RvD5, and RvD6; see specialized proresolving mediators#DHA-derived Resolvins) are docosanoid...
PMC 5312008. PMID 28151409. Qu Q, Xuan W, Fan GH (January 2015). "Roles of resolvins in the resolution of acute inflammation". Cell Biology International....
eicosanoid derivatives formed via the lipoxygenase pathway from ω-6 EFAs and resolvins from ω-3 (in the presence of acetylsalicylic acid, downregulating inflammation)...
anti-inflammatory activity and its metabolism toward neuroprotectins and resolvins, the latter of which directly contribute to cardiac function. DHA is associated...
1182/blood-2015-12-624296. PMID 26989202. Qu Q, Xuan W, Fan GH (January 2015). "Roles of resolvins in the resolution of acute inflammation". Cell Biology International....
compounds and candidates for future drug development. Resolvin D1 (RvD1) and RvD2 (see resolvins) and maresin 1 are metabolites of the omega 3 fatty acid...
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