excitatory extracellular ligand-gated ion channel activity
calcium channel activity
extracellular ligand-gated ion channel activity
phosphatidylinositol binding
metal ion binding
calmodulin binding
protein binding
Cellular component
integral component of membrane
postsynaptic membrane
cell projection
membrane
plasma membrane
synapse
cell junction
dendritic spine membrane
cytosol
neuronal cell body
intrinsic component of plasma membrane
dendrite
external side of plasma membrane
neuron projection
integral component of plasma membrane
mitochondrion
Biological process
ion transport
chemosensory behavior
cell surface receptor signaling pathway
calcium ion transmembrane transport
thermoception
calcium ion transport
inflammatory response
transmembrane transport
release of sequestered calcium ion into cytosol
negative regulation of transcription by RNA polymerase II
diet induced thermogenesis
detection of chemical stimulus involved in sensory perception of pain
microglial cell activation
cellular response to growth factor stimulus
positive regulation of gastric acid secretion
response to peptide hormone
cellular response to nerve growth factor stimulus
positive regulation of nitric oxide biosynthetic process
negative regulation of establishment of blood-brain barrier
lipid metabolism
temperature homeostasis
response to heat
cellular response to temperature stimulus
positive regulation of cytosolic calcium ion concentration
peptide secretion
detection of temperature stimulus involved in sensory perception of pain
sensory perception of mechanical stimulus
smooth muscle contraction involved in micturition
behavioral response to pain
response to pain
cellular response to alkaloid
cellular response to cytokine stimulus
fever generation
detection of temperature stimulus involved in thermoception
positive regulation of apoptotic process
urinary bladder smooth muscle contraction
glutamate secretion
sensory perception of pain
cellular response to tumor necrosis factor
cellular response to ATP
ion transmembrane transport
response to pH
response to organonitrogen compound
cellular response to heat
protein homotetramerization
excitatory postsynaptic potential
cellular response to acidic pH
response to capsazepine
calcium ion import across plasma membrane
negative regulation of systemic arterial blood pressure
negative regulation of heart rate
negative regulation of mitochondrial membrane potential
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7442
193034
Ensembl
ENSG00000196689
ENSMUSG00000005952
UniProt
Q8NER1
Q704Y3
RefSeq (mRNA)
NM_018727 NM_080704 NM_080705 NM_080706
NM_001001445
RefSeq (protein)
NP_061197 NP_542435 NP_542436 NP_542437
NP_001001445
Location (UCSC)
Chr 17: 3.57 – 3.61 Mb
Chr 11: 73.13 – 73.15 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group.[5][6] This protein is a member of the TRPV group of transient receptor potential family of ion channels.[7] Fatty acid metabolites with affinity for this receptor are produced by cyanobacteria, which diverged from eukaryotes at least 2000 million years ago (MYA).[8]
The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain (nociception). In primary afferent sensory neurons, it cooperates with TRPA1[9][10] (a chemical irritant receptor) to mediate the detection of noxious environmental stimuli.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000196689 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000005952 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (October 1997). "The capsaicin receptor: a heat-activated ion channel in the pain pathway". Nature. 389 (6653): 816–824. Bibcode:1997Natur.389..816C. doi:10.1038/39807. PMID 9349813. S2CID 7970319.
^Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA (August 2001). "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants". Genomics. 76 (1–3): 14–20. doi:10.1006/geno.2001.6582. PMID 11549313.
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^McPartland JM (2004-04-01). "Phylogenomic and chemotaxonomic analysis of the endocannabinoid system". Brain Research Reviews. 45 (1): 18–29. doi:10.1016/j.brainresrev.2003.11.005. ISSN 0165-0173. PMID 15063097. S2CID 25038370.
^Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (April 2015). "Structure of the TRPA1 ion channel suggests regulatory mechanisms". Nature. 520 (7548): 511–517. Bibcode:2015Natur.520..511P. doi:10.1038/nature14367. PMC 4409540. PMID 25855297.
^Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D (September 2020). "Irritant-evoked activation and calcium modulation of the TRPA1 receptor". Nature. 585 (7823): 141–145. Bibcode:2020Natur.585..141Z. doi:10.1038/s41586-020-2480-9. PMC 7483980. PMID 32641835. S2CID 220407248.
^Basbaum AI, Bautista DM, Scherrer G, Julius D (October 2009). "Cellular and molecular mechanisms of pain". Cell. 139 (2): 267–284. doi:10.1016/j.cell.2009.09.028. PMC 2852643. PMID 19837031.
member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was...
as TRPV1. In response to heat, the TRPV1 receptor opens up passages that allow ions to pass through, causing the sensation of heat or burning. TRPV1 also...
receptor 1 (TRPV1) in a subpopulation of primary afferent sensory neurons involved in nociception, the transmission of physiological pain. TRPV1 is an ion...
agents is being intensively studied by the pharmaceutical industry. The TRPV1 receptor is a ligand gated ion channel that has been implicated in mediation...
heat-activation of TRPV1 channels has yet to be deciphered. TRPV1-S (TRPV1 short) is an isoform of the capsaicin receptor TRPV1 and comprises 35-46% of TRPV1 transcripts...
for the transient receptor potential cation channel subfamily V member 1 (TRPV1), activating the pain sensory system. VaTx1 and 2 also act as antagonists...
use of TRPV1 agonists would potentially inhibit nociception at TRPV1, particularly in pancreatic tissue where TRPV1 is highly expressed. The TRPV1 agonist...
heat-sensitive, TRPV1, by lowering its thermal activation threshold to about 30 °C (86 °F). This is achieved through alternative splicing of TRPV1 transcripts...
centipede. RhTx binds to the outer pore region of the temperature regulated TRPV1 ion channel, preferably in activated state, causing a downwards shift in...
Mavatrep (JNJ‐39439335) is a TRPV1 receptor selective competitive antagonist. It is an investigational analgesic that may be a potential treatment for...
chilli pepper) which activates the TRPV1 ion channel. Capsazepine is therefore considered to be a TRPV1 antagonist. The TRPV1 channel functions as a pain and...
predominantly by birds. In birds, the TRPV1 channel does not respond to capsaicin or related chemicals but mammalian TRPV1 is very sensitive to it. This is...
Binding has been demonstrated by 2-arachidonoylglycerol (2-AG) on the TRPV1 receptor suggesting that this receptor may be a candidate for the established...
analogue of capsaicin which acts as a potent and selective agonist for the TRPV1 receptor, with slightly lower potency than resiniferatoxin, though still...
notably capsaicin, bind to the transient receptor potential vanilloid type 1 (TRPV1) receptor, an ion channel which naturally responds to noxious stimuli such...
and the lachrymatory effect of AITC are mediated through the TRPA1 and TRPV1 ion channels. It is slightly soluble in water, but more soluble in most...
mechanisms of pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He...
Transient receptor potential cation channel subfamily V member 1 (TRPV1). Ion channels are integral membrane proteins of great importance for living organisms...
seeds). This is consistent with nonivamide's role as a TRPV1 ion channel agonist. Mammalian TRPV1 is activated by heat and capsaicin, but the avian form...
use of TRPV1 agonists would potentially inhibit nociception at TRPV1, particularly in pancreatic tissue where TRPV1 is highly expressed. The TRPV1 agonist...
Zucapsaicin mediates an antinociceptive action via acting as an agonist at TRPV1. TRPV1 play an important physiological role of transducing chemical, mechanical...
transporter, and a potent activator of TRPV1 receptor. This and other research indicate that the cannabinoid system and TRPV1 may play an important role in the...
CB1 and CB2, beside involvement of transient receptor vanilloid type-1 (TRPV1) channels in the pain modulation, as endovanilloid signalling modulates...
de Jesus IC, Ferreira LA, et al. (December 2020). "Ketamine potentiates TRPV1 receptor signaling in the peripheral nociceptive pathways". Biochemical...
Global Information
