The Kell antigen system (also known as the Kell–Cellano system) is a human blood group system, that is, a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. The Kell antigens are K, k, Kpa, Kpb, Jsa and Jsb.[1] The Kell antigens are peptides found within the Kell protein, a 93-kilodalton transmembrane zinc-dependent endopeptidase which is responsible for cleaving endothelin-3.[2][3]
^Smart, E.; Armstrong, B. (2008). "Blood group systems". ISBT Science Series. 3 (2): 68–92. doi:10.1111/j.1751-2824.2008.00188.x. ISSN 1751-2816.
^Lee S, Wu X, Reid M, Zelinski T, Redman C (February 1995). "Molecular basis of the Kell (K1) phenotype". Blood. 85 (4): 912–6. doi:10.1182/blood.V85.4.912.bloodjournal854912. PMID 7849312.
^Lee S, Lin M, Mele A, Cao Y, Farmar J, Russo D, Redman C (August 1999). "Proteolytic processing of big endothelin-3 by the kell blood group protein". Blood. 94 (4): 1440–50. doi:10.1182/blood.V94.4.1440. PMID 10438732. Archived from the original on 2013-04-14.
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in development and before the Kellantigens, Rhesus-associated glycoprotein, glycophorin A, band 3, the Rhesus antigen and glycophorin B. In melanocytic...
transfusion medicine include the RhC/c and E/e antigens and the antigens of the Duffy, Kell, Kidd, and MNS systems.: 158–173 If a clinically significant antibody...
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(DAT), is used to detect if antibodies or complement system factors have bound to RBCs surface antigens. The DAT is not required for pre-transfusion testing...
system. Hemolytic reactions may also be caused by incompatibilities with Rh factors, Duffy antigens, Kellantigens, Kidd antigens, and Lewis antigens...
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can cause AHTR, the most common of which is Kidd antigen incompatibility. Rh, Kell, and Duffy antigen incompatibility have also been implicated in AHTR...
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caused by mutations in the XK gene encoding the Kx blood type antigen, one of the Kellantigens. Like the other neuroacanthocytosis syndromes, McLeod syndrome...