antigen processing and presentation, exogenous lipid antigen via MHC class Ib
adaptive immune response
immune system process
immune response
regulation of immune response
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
909
n/a
Ensembl
ENSG00000158477
n/a
UniProt
P06126
n/a
RefSeq (mRNA)
NM_001763 NM_001320652
n/a
RefSeq (protein)
NP_001307581 NP_001754
n/a
Location (UCSC)
Chr 1: 158.25 – 158.26 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene.[3]
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[3] Transcript levels of the CD1A gene are upregulated in the lung parenchyma of smokers.[4]
^ abcGRCh38: Ensembl release 89: ENSG00000158477 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: CD1A CD1a molecule".
^Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F (September 2019). "Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients". Scientific Reports. 9 (1): 13039. Bibcode:2019NatSR...913039P. doi:10.1038/s41598-019-49648-2. PMC 6736939. PMID 31506599.
CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene. This gene encodes a member of the CD1 family of transmembrane glycoproteins...
of tissue-derived CD1a-presented autoantigens and the first CD1a-lipid-TCR structure, between an autoreactive TCR which bound the CD1a without contacting...
but have undergone further differentiation. Skin Langerhans cells express CD1a, as do cortical thymocytes (cells of the cortex of the thymus gland). They...
1501141. PMID 26416282. Wilson, AJ; Maddox, PH; Jenkins, D (January 1991). "CD1a and S100 antigen expression in skin Langerhans cells in patients with breast...
interstitial lung disease. PLCH develops when an abundance of monoclonal CD1a-positive Langerhans (immature histiocytes) proliferate the bronchioles and...
nutritional predisposition to the disease.". On the other hand, reduced CD1a+ Langerhans cells and CD207+ dendritic cells indicate evolving immunosuppression...
the lung parenchyma; the expression levels of a panel of seven genes (KMO, CD1A, SPINK5, TREM2, CYBB, DNASE2B, FGG) are increased in the lung tissue of smokers...
(June 2006). "40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin". The Journal of Investigative...
lipid molecules CD1aCD1a (Cluster of Differentiation 1a), or T-cell surface glycoprotein CD1a, is a human protein encoded by the CD1A gene. An antigen-presenting...
with Langerhans cells as they uniquely express CD14 and FXIIIa and lack CD1a. The prenatal portion of tissue-resident dermal macrophages is produced from...
National Library of Medicine Medical Subject Headings (MeSH) Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser. Human CD1D genome...
inside the Birbeck granules, it contributes to the binding of the antigen to CD1a molecule. In mice, langerin is involved in antigen binding to MHC II glycoproteins...
histiocytomas have the phenotype of epidermal Langerhans cells. They express CD1a, CD1b, CD1c, MHC class II, CD11c, and E-cadherin. Amongst leukocytes, E-cadherin...
through e. The a through d subtypes are capable of binding to sulfatide. CD1a, CD1b, and CD1c subtypes present lipid antigens to T cells, while CD1d cells...
Global Information
