For the album by Throbbing Gristle, see CD1 (album).
CD1a molecule
Identifiers
Symbol
CD1A
Alt. symbols
CD1
NCBI gene
909
HGNC
1634
OMIM
188370
RefSeq
NM_001763
UniProt
P06126
Other data
Locus
Chr. 1 q22-q23
Search for
Structures
Swiss-model
Domains
InterPro
CD1b molecule
Identifiers
Symbol
CD1B
Alt. symbols
CD1
NCBI gene
910
HGNC
1635
OMIM
188360
RefSeq
NM_001764
UniProt
P29016
Other data
Locus
Chr. 1 q22-q23
Search for
Structures
Swiss-model
Domains
InterPro
CD1c molecule
Identifiers
Symbol
CD1C
Alt. symbols
CD1
NCBI gene
911
HGNC
1636
OMIM
188340
RefSeq
NM_001765
UniProt
P29017
Other data
Locus
Chr. 1 q22-q23
Search for
Structures
Swiss-model
Domains
InterPro
CD1d molecule
Identifiers
Symbol
CD1D
NCBI gene
912
HGNC
1637
OMIM
188410
RefSeq
NM_001766
UniProt
P15813
Other data
Locus
Chr. 1 q22-q23
Search for
Structures
Swiss-model
Domains
InterPro
CD1e molecule
Identifiers
Symbol
CD1E
NCBI gene
913
HGNC
1638
OMIM
188411
RefSeq
NM_030893
UniProt
P15812
Other data
Locus
Chr. 1 q22-q23
Search for
Structures
Swiss-model
Domains
InterPro
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune response. Both αβ and γδ T cells recognise CD1 molecules.[1][2]
The human CD1 gene cluster is located on chromosome 1. Genes of the CD1 family were first cloned in 1986, by Franco Calabi and C. Milstein, whereas the first known lipid antigen for CD1 was discovered in 1994, during studies of Mycobacterium tuberculosis.[3] The first antigen that was discovered to be able to bind CD1 and then be recognised by TCR is C80 mycolic acid. Even though their precise function is unknown, The CD1 system of lipid antigen recognition by TCR offers the prospect of discovering new approaches to therapy and developing immunomodulatory agents.[4][1][5][2]
^ abLayre E, de Jong A, Moody DB (December 2014). "Human T cells use CD1 and MR1 to recognize lipids and small molecules". Current Opinion in Chemical Biology. Molecular immunology. 23: 31–38. doi:10.1016/j.cbpa.2014.09.007. PMID 25271021.
^ abTang Y, Ma S, Lin S, Wu Y, Chen S, Liu G, Ma L, Wang Z, Jiang L, Wang Y (2023-03-01). "Cell-free protein synthesis of CD1E and B2M protein and in vitro interaction". Protein Expression and Purification. 203: 106209. doi:10.1016/j.pep.2022.106209. ISSN 1046-5928. PMID 36460227. S2CID 254180046.
^Van Rhijn I, Godfrey DI, Rossjohn J, Moody DB (October 2015). "Lipid and small-molecule display by CD1 and MR1". Nature Reviews. Immunology. 15 (10): 643–654. doi:10.1038/nri3889. PMC 6944187. PMID 26388332.
^Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (October 1989). "Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes". Nature. 341 (6241): 447–450. Bibcode:1989Natur.341..447P. doi:10.1038/341447a0. PMID 2477705. S2CID 4264602.
^Moody DB, Suliman S (2017-10-30). "CD1: From Molecules to Diseases". F1000Research. 6: 1909. doi:10.12688/f1000research.12178.1. PMC 5664979. PMID 29152228.
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