CALM2 information

CALM2
Identifiers
Aliases	CALM2, CAMII, PHKD, PHKD2, LQT15, caM, calmodulin 2 (phosphorylase kinase, delta), calmodulin 2, CAMC, CAM1, CAMIII, CAM3, CALM, CALML2
External IDs	OMIM: 114182; HomoloGene: 134804; GeneCards: CALM2; OMA:CALM2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	47,176,921 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; orbitofrontal cortex; ; visceral pleura; ; pons; ; occipital lobe; ; germinal epithelium; ; parietal pleura; ; prefrontal cortex; ; entorhinal cortex;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein binding; adenylate cyclase binding; adenylate cyclase activator activity; calcium channel inhibitor activity; protein kinase binding; protein domain specific binding; titin binding; N-terminal myristoylation domain binding; protein serine/threonine kinase activator activity; transmembrane transporter binding; metal ion binding; protein phosphatase activator activity; disordered domain specific binding; nitric-oxide synthase regulator activity; type 3 metabotropic glutamate receptor binding; phosphatidylinositol 3-kinase binding; protein N-terminus binding; calcium-dependent protein binding; nitric-oxide synthase binding;
Cellular component	spindle pole; nucleus; cytoplasm; centrosome; microtubule organizing center; spindle; cytoskeleton; spindle microtubule; plasma membrane; voltage-gated potassium channel complex; sarcomere; vesicle; protein-containing complex; calcium channel complex; myelin sheath; catalytic complex; growth cone; synaptic vesicle membrane; mitochondrial membranes; neuron projection;
Biological process	G2/M transition of mitotic cell cycle; regulation of heart rate; detection of calcium ion; G protein-coupled receptor signaling pathway; positive regulation of peptidyl-threonine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; calcium-mediated signaling; substantia nigra development; positive regulation of protein autophosphorylation; regulation of cytokinesis; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein dephosphorylation; positive regulation of DNA binding; positive regulation of cyclic-nucleotide phosphodiesterase activity; response to calcium ion; regulation of cardiac muscle contraction; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of protein serine/threonine kinase activity; regulation of cell communication by electrical coupling involved in cardiac conduction; response to amphetamine; activation of adenylate cyclase activity; positive regulation of nitric-oxide synthase activity; response to corticosterone; regulation of ryanodine-sensitive calcium-release channel activity; establishment of protein localization to membrane; establishment of protein localization to mitochondrial membrane; regulation of synaptic vesicle endocytosis; regulation of high voltage-gated calcium channel activity; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	805
	n/a
	ENSG00000143933
	n/a
	P0DP31; P0DP24
	n/a
	NM_001305624; NM_001305625; NM_001305626; NM_001743
	n/a
NP_059022; NP_001350598; NP_001350599; NP_008819; NP_001292553;
	NP_001292554; NP_001292555; NP_001734; NP_001316850; NP_001316851; NP_001316852; NP_001316853; NP_001316854; NP_001316855; NP_005175
	n/a
	Wikidata
View/Edit Human

Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene.^[3]^[4] A member of the calmodulin family of signaling molecules, it is an intermediary between calcium ions, which act as a second messenger, and many intracellular processes, such as the contraction of cardiac muscle.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143933 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)".
^ SenGupta B, Friedberg F, Detera-Wadleigh SD (December 1987). "Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species". The Journal of Biological Chemistry. 262 (34): 16663–16670. doi:10.1016/S0021-9258(18)49306-4. PMID 2445749.
^ "Entry - *114205 - CALCIUM CHANNEL, VOLTAGE-DEPENDENT, L TYPE, ALPHA-1C SUBUNIT; CACNA1C - OMIM". omim.org. Retrieved 2023-06-01.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143933 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)".

[pmid2445749-4] SenGupta B, Friedberg F, Detera-Wadleigh SD (December 1987). "Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species". The Journal of Biological Chemistry. 262 (34): 16663–16670. doi:10.1016/S0021-9258(18)49306-4. PMID 2445749.

[5] "Entry - *114205 - CALCIUM CHANNEL, VOLTAGE-DEPENDENT, L TYPE, ALPHA-1C SUBUNIT; CACNA1C - OMIM". omim.org. Retrieved 2023-06-01.

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