Bone marrow adipocytes are derived from mesenchymal stem cell (MSC) differentiation.
Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. It increases in states of low bone density -osteoporosis,[1][2] anorexia nervosa/caloric restriction,[3][4] skeletal unweighting such as that which occurs in space travel,[5][6] and anti-diabetes therapies.[7] BMAT decreases in anaemia, leukaemia, and hypertensive heart failure; in response to hormones such as oestrogen, leptin, and growth hormone; with exercise-induced weight loss or bariatric surgery; in response to chronic cold exposure; and in response to pharmacological agents such as bisphosphonates, teriparatide, and metformin.[8]
^Cohen A, Dempster DW, Stein EM, Nickolas TL, Zhou H, McMahon DJ, et al. (August 2012). "Increased marrow adiposity in premenopausal women with idiopathic osteoporosis". The Journal of Clinical Endocrinology and Metabolism. 97 (8): 2782–2791. doi:10.1210/jc.2012-1477. PMC 3410269. PMID 22701013.
^Meunier P, Aaron J, Edouard C, Vignon G (October 1971). "Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies". Clinical Orthopaedics and Related Research. 80: 147–154. doi:10.1097/00003086-197110000-00021. PMID 5133320.
^Fazeli PK, Horowitz MC, MacDougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, Klibanski A (March 2013). "Marrow fat and bone--new perspectives". The Journal of Clinical Endocrinology and Metabolism. 98 (3): 935–945. doi:10.1210/jc.2012-3634. PMC 3590487. PMID 23393168.
^McGrath C, Sankaran JS, Misaghian-Xanthos N, Sen B, Xie Z, Styner MA, et al. (January 2020). "Exercise Degrades Bone in Caloric Restriction, Despite Suppression of Marrow Adipose Tissue (MAT)". Journal of Bone and Mineral Research. 35 (1): 106–115. doi:10.1002/jbmr.3872. PMC 6980282. PMID 31509274.
^Ahdjoudj S, Lasmoles F, Holy X, Zerath E, Marie PJ (April 2002). "Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma". Journal of Bone and Mineral Research. 17 (4): 668–677. doi:10.1359/jbmr.2002.17.4.668. PMID 11918224. S2CID 23060094.
^Wronski TJ, Morey ER (1982-01-01). "Skeletal abnormalities in rats induced by simulated weightlessness". Metabolic Bone Disease & Related Research. 4 (1): 69–75. doi:10.1016/0221-8747(82)90011-X. PMID 7121257.
^Rubin MR, Manavalan JS, Agarwal S, McMahon DJ, Nino A, Fitzpatrick LA, Bilezikian JP (October 2014). "Effects of rosiglitazone vs metformin on circulating osteoclast and osteogenic precursor cells in postmenopausal women with type 2 diabetes mellitus". The Journal of Clinical Endocrinology and Metabolism. 99 (10): E1933–E1942. doi:10.1210/jc.2013-3666. PMID 24905061.
^Cawthorn W (2020). "Bone Marrow Adipose Tissue". Encyclopedia of Bone Biology. Oxford, UK: Academic Press. pp. 156–177. doi:10.1016/B978-0-12-801238-3.11207-3. ISBN 978-0-12-814082-6. S2CID 213762507.
and 29 Related for: Bone marrow adipose tissue information
(visceral fat), in bonemarrow (yellow bonemarrow), intermuscular (Muscular system) and in the breast (breast tissue). Adiposetissue is found in specific...
of bone shafts where red bonemarrow and/or yellow bonemarrow (adiposetissue) is stored; hence, the medullary cavity is also known as the marrow cavity...
yellow fraction called marrowadiposetissue (MAT) increases in quantity. In adults, red marrow is mostly found in the bonemarrow of the femur, the ribs...
osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrowadiposetissue). Mesenchymal...
consists of loose connective tissue (including reticular connective tissue and adiposetissue) and dense connective tissue (subdivided into dense regular...
to bone health. Marrowadiposetissue expands in states of low bone density but additionally expands in the setting of obesity. Marrowadiposetissue response...
the designations areolar tissue, adiposetissue, and reticular tissue have been listed as subsets of loose connective tissue. However, they are no longer...
support the lymphoid organs (lymph node stromal cells, red bonemarrow, and spleen). Adiposetissue is held together by reticular fibers. They can be identified...
bone. It is made up of cortical bone and usually contains bonemarrow and adiposetissue (fat). It is a middle tubular part composed of compact bone which...
Bone resorption is resorption of bonetissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting...
anorexia nervosa. Furthermore, a recent study suggests that adiposetissue within bonemarrow, which increases during caloric restriction, contributes to...
health and donor site morbidity may be deterrents to their use. Adipose-derived and bonemarrow-derived mesenchymal stem cells are commonly autologous in nature...
from the patients own tissues. Multiple clinical studies are ongoing that obtain stromal cells from bone-marrow, adiposetissue, or peripheral blood to...
the bonemarrow constitute the primary lymphoid organs involved in the production and early clonal selection of lymphocyte tissues. Bonemarrow is responsible...
protein is a protein hormone predominantly made by adipocytes (cells of adiposetissue). Its primary role is likely to regulate long-term energy balance. As...
multipotent, which can be found in adult tissues, for example, in the muscle, liver, bonemarrow and adiposetissue. Mesenchymal stem cells usually function...
to their exit from the bonemarrow. After maturation, eosinophils circulate in blood and migrate to inflammatory sites in tissues, or to sites of helminth...
contains a highly metabolic set of tissues including trabecular (spongy) bone, blood vessels , as well as MarrowAdiposeTissue (MAT). The metaphysis may be...
obtainable mesenchymal cells such as human fibroblasts, bonemarrow-mesenchymal stem cells and adipose-derived stem cells as 1~several percent of the total...
from preadipocytes resident in adiposetissue, or from bone-marrow derived progenitor cells that migrate to adiposetissue. Adipocytes play a vital role...
phagocyte system. The monocyte is formed in the bonemarrow and transported by the blood; it migrates into the tissues, where it transforms into a histiocyte or...
of marrow adipocytes which comprise marrowadiposetissue (MAT). Osteoblasts are found in large numbers in the periosteum, the thin connective tissue layer...
through its effects on bone, kidney, and intestine. PTH influences bone remodeling, which is an ongoing process in which bonetissue is alternately resorbed...
found in abundance within bonemarrow but can also be seen all around the body. Stromal cells can become connective tissue cells of any organ, for example...
orientation; a muscle tissue engineered construct for a smooth muscle cell precursor Intracoronary Administration of BoneMarrow-Derived Progenitor Cells:...
his team also focused on using multi-potential bonemarrow, adiposetissue, or placenta & cord tissue-derived MSCs for regenerative medicine, pioneering...
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