Not to be confused with reticulocyte or reticular cell.
In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) also known as the reticuloendothelial system or macrophage system is a part of the immune system that consists of the phagocytic cells[1] located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the liver and tissue histiocytes are also part of the MPS. The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one.[citation needed]
"Reticuloendothelial system" is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most endothelial cells are not macrophages.[2]
The mononuclear phagocyte system is also a somewhat dated concept trying to combine a broad range of cells, and should be used with caution.[3]
^Mononuclear+Phagocyte+System at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^Inderbir Singh (2006). Textbook of human histology. Jaypee Brothers Publishers. pp. 90–. ISBN 978-81-8061-809-3. Retrieved 12 November 2010.
^Hume, David A (2006-02-01). "The mononuclear phagocyte system". Current Opinion in Immunology. Innate immunity / Antigen processing and recognition. 18 (1): 49–53. doi:10.1016/j.coi.2005.11.008. PMID 16338128.
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immunology, the mononuclearphagocytesystem or mononuclearphagocyticsystem (MPS) also known as the reticuloendothelial system or macrophage system is a part...
the term "reticuloendothelial system" (abbreviated RES), often associated nowadays with the mononuclearphagocytesystem (MPS), was employed by the beginning...
hemorrhagic shock, and also recycles iron. As a part of the mononuclearphagocytesystem, it metabolizes hemoglobin removed from senescent red blood cells...
accumulation of hemosiderin is usually detected within cells of the mononuclearphagocytesystem (MPS) or occasionally within epithelial cells of the liver and...
monocytes are the largest cell type in peripheral blood. Monocytes are mononuclear cells and the ellipsoidal nucleus is often lobulated/indented, causing...
liver transplantation and liver fibrosis. They form part of the mononuclearphagocytesystem. Kupffer cells can be found attached to sinusoidal endothelial...
promoting tissue healing. The spleen is a center of activity of the mononuclearphagocytesystem and can be considered analogous to a large lymph node, as its...
tissue-resident phagocytes that facilitate microbial debris clearance in the skin. Dermal macrophages belong to the mononuclearphagocytesystem that serves...
epithelioid cells to the mononuclearphagocytesystem. However, they did not specify exactly from which cells of the mononuclearphagocytesystem epithelioid cells...
kala-azar, the most severe form of leishmaniasis. It infects the mononuclearphagocytesystem including spleen, liver and bone marrow. Infection is transmitted...
macrophages, microglia, and others), but all are part of the mononuclearphagocytesystem. Besides phagocytosis, they play a critical role in nonspecific...
border. Because of their phagocytic properties, osteoclasts are considered to be a component of the mononuclearphagocytesystem (MPS). The activity of...
blood. The liver is responsible for immunological effects – the mononuclearphagocytesystem of the liver contains many immunologically active cells, acting...
recognition by macrophages and subsequent phagocytosis in the mononuclearphagocytesystem (spleen, liver and lymph nodes), thus removing old and defective...
the mononuclearphagocytesystem, a network of connective tissue that contains immune cells, and surrounds tissue associated with the immune system throughout...
haemoglobin degradation. The haemoglobin that is released after the mononuclearphagocytesystem (located in the liver and spleen) withdraws old red blood cells...
cells that are a part of the mononuclearphagocyticsystem, a part of the body's immune system that consists of phagocytic cells, which are responsible...
this way the infection is progressive, spreading to the host's mononuclearphagocytesystem, particularly the spleen and liver. The free amastigotes in peripheral...
(which are not fixed and organized in solid tissue) in particular mononuclearphagocytes. Frequently, the term refers to circulating macrophages and has...
product formed from the breakdown of hemoglobin. Cells of the mononuclearphagocytesystem digest aged red blood cells and release unconjugated bilirubin...
the foal, leading to lysis through the complement system or removal by the mononuclearphagocytesystem, and causing subsequent anemia. Most blood groups...
(2003). Free Radicals and Inhalation Pathology: Respiratory System, MononuclearPhagocyteSystem, Hypoxia and Reoxygenation, Pneumoconioses, and Other Granulomatoses...
brucellosis share the persistence of the bacteria in tissues of the mononuclearphagocytesystem, including the spleen, liver, lymph nodes, and bone marrow. Brucella...
used with MPI are cleared naturally by the body through the mononuclearphagocytesystem. The iron oxide nanoparticles are broken down in the liver, where...
reticuloendothelial system", or RES. For several decades it was believed that the cells comprising the RES were the macrophages of the mononuclearphagocytesystem (MPS)...
Heul-Nieuwenhuijzen L, Beumer W, Versnel MA, Drexhage HA (January 2010). "The mononuclearphagocytesystem and its cytokine inflammatory networks in schizophrenia and bipolar...
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