Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing damaged bases that could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-patch BER (where 2–10 new nucleotides are synthesized).[1]
^Liu Y, Prasad R, Beard WA, Kedar PS, Hou EW, Shock DD, Wilson SH (2007). "Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/Apyrimidinic Endonuclease 1 and DNA Polymerase β". Journal of Biological Chemistry. 282 (18): 13532–13541. doi:10.1074/jbc.M611295200. PMC 2366199. PMID 17355977.
and 24 Related for: Base excision repair information
Baseexcisionrepair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle...
mutagens. Three excisionrepair pathways exist to repair single stranded DNA damage: Nucleotide excisionrepair (NER), baseexcisionrepair (BER), and DNA...
are a family of enzymes involved in baseexcisionrepair, classified under EC number EC 3.2.2. Baseexcisionrepair is the mechanism by which damaged bases...
enzyme needs access to the base to perform work on it, such as its excision for replacement with another base during DNA repair. It was first observed in...
kinases perform repair regulation at three levels - via PTMs, at the level of chromatin, and at the level of the nucleus. Baseexcisionrepair (BER) is responsible...
Stage 3: Baseexcision DNA repair. The intermediate products of demethylation are catalysed by specific enzymes of the baseexcision DNA repair pathway...
Mouse models of nucleotide-excision–repair syndromes reveal a striking correlation between the degree to which specific DNA repair pathways are compromised...
intermediates in baseexcisionrepair. In this process, a DNA glycosylase recognizes a damaged base and cleaves the N-glycosidic bond to release the base, leaving...
involved in baseexcisionrepair. It is found in bacterial, archaeal and eukaryotic species. OGG1 is the primary enzyme responsible for the excision of 8-oxoguanine...
DNA. XRCC1 is involved in single-strand break repair, baseexcisionrepair and nucleotide excisionrepair. As reviewed by London, XRCC1 protein has three...
enrichment for transversion mutations (G:C>T:A) has been associated with baseexcisionrepair (BER) deficiency and linked to defective MUTYH, a DNA glycosylase...
glycosylase. It is involved in oxidative DNA damage repair and is part of the baseexcisionrepair pathway. The enzyme excises adenine bases from the DNA...
divisions. The process of DNA demethylation involves baseexcisionrepair and likely other DNA-repair-based mechanisms. Despite the global nature of this process...
Reprogramming involves global DNA demethylation facilitated by the DNA baseexcisionrepair pathway as well as chromatin reorganization, and results in cellular...
cytosine results in a uracil, which as a foreign base is quickly replaced by a cytosine by the baseexcisionrepair mechanism. The C to T transition rate at methylated...
the process of baseexcisionrepair are sensitive to bile salts. This indicates that wild-type S. enterica uses baseexcisionrepair to remove DNA damages...
endonuclease is an enzyme that is involved in the DNA baseexcisionrepair pathway (BER). Its main role in the repair of damaged or mismatched nucleotides in DNA...
chromatin-associated protein that is required for normal baseexcisionrepair and double-strand break repair of DNA damage in mammalian cells. Deficiency of SIRT6...
encodes DNA ligase I, which functions in DNA replication and the baseexcisionrepair process. Eukaryotic DNA ligase 1 catalyzes a reaction that is chemically...
Global Information