Werner syndrome helicase information

WRN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AXL, 2DGZ, 2E1E, 2E1F, 2FBT, 2FBV, 2FBX, 2FBY, 2FC0, 3AAF
Identifiers
Aliases	WRN, RECQ3, RECQL2, RECQL3, Werner syndrome RecQ like helicase, WRN RecQ like helicase
External IDs	OMIM: 604611 MGI: 109635 HomoloGene: 6659 GeneCards: WRN
EC number	3.1.-.-
Gene location (Human)
Chr.	Chromosome 8 (human)
End	31,176,138 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	33,875,555 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sperm; ; gastric mucosa; ; secondary oocyte; ; sural nerve; ; skin of abdomen; ; body of pancreas; ; left uterine tube; ; bone marrow; ; rectum;
	Top expressed in
	spermatid; ; secondary oocyte; ; spermatocyte; ; cumulus cell; ; ascending aorta; ; aortic valve; ; thymus; ; bone marrow; ; seminiferous tubule; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; manganese ion binding; protein homodimerization activity; helicase activity; DNA helicase activity; bubble DNA binding; chromatin binding; metal ion binding; G-quadruplex DNA binding; ATPase activity; protein binding; catalytic activity; 3'-5' exonuclease activity; Y-form DNA binding; nucleic acid binding; nuclease activity; 3'-5' DNA helicase activity; four-way junction helicase activity; ATP binding; magnesium ion binding; hydrolase activity; exonuclease activity; telomeric D-loop binding; 3'-flap-structured DNA binding; four-way junction DNA binding; forked DNA-dependent helicase activity; telomeric G-quadruplex DNA binding; 8-hydroxy-2'-deoxyguanosine DNA binding; protein-containing complex binding; MutLalpha complex binding;
Cellular component	centrosome; intracellular anatomical structure; nucleoplasm; nucleolus; neuron projection; MutLalpha complex; nucleus; cytoplasm; nuclear speck; telomere; replication fork; DNA replication factor A complex; chromosome; site of double-strand break;
Biological process	regulation of apoptotic process; positive regulation of hydrolase activity; DNA recombination; cellular response to starvation; DNA metabolic process; human ageing; response to oxidative stress; cellular response to DNA damage stimulus; regulation of growth rate; brain development; cell metabolism; cellular response to gamma radiation; replication fork processing; multicellular organism aging; metabolism; nucleobase-containing compound metabolic process; response to UV-C; base-excision repair; double-strand break repair; DNA repair; nucleic acid phosphodiester bond hydrolysis; double-strand break repair via homologous recombination; DNA duplex unwinding; DNA replication; telomeric D-loop disassembly; t-circle formation; positive regulation of strand invasion; telomere maintenance; G-quadruplex DNA unwinding; protein localization to nucleolus; DNA synthesis involved in DNA repair; determination of adult lifespan; regulation of signal transduction by p53 class mediator; DNA unwinding involved in DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	7486
	22427
	ENSG00000165392
	ENSMUSG00000031583
	Q14191
	O09053
	NM_000553
	NM_001122822; NM_011721
	NP_000544
	NP_001116294; NP_035851
	Wikidata
View/Edit Human	View/Edit Mouse

Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a member of the RecQ Helicase family.^[5] Helicase enzymes generally unwind and separate double-stranded DNA. These activities are necessary before DNA can be copied in preparation for cell division (DNA replication). Helicase enzymes are also critical for making a blueprint of a gene for protein production, a process called transcription. Further evidence suggests that Werner protein plays a critical role in repairing DNA. Overall, this protein helps maintain the structure and integrity of a person's DNA.

The WRN gene is located on the short (p) arm of chromosome 8 between positions 12 and 11.2, from base pair 31,010,319 to base pair 31,150,818.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165392 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031583 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference Monnat was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165392 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031583 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Monnat-5] Cite error: The named reference Monnat was invoked but never defined (see the help page).

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