3' overhang single-stranded DNA endodeoxyribonuclease activity
oxidized DNA binding
Cellular component
nucleoplasm
ERCC4-ERCC1 complex
nucleus
nucleolus
Biological process
single strand break repair
nucleotide-excision repair, DNA gap filling
transcription-coupled nucleotide-excision repair
response to hypoxia
response to organic substance
double-strand break repair via homologous recombination
cellular response to DNA damage stimulus
base-excision repair, DNA ligation
hippocampus development
DNA repair
double-strand break repair via nonhomologous end joining
negative regulation of protection from non-homologous end joining at telomere
telomeric DNA-containing double minutes formation
base-excision repair
negative regulation of protein ADP-ribosylation
positive regulation of DNA ligase activity
cerebellum morphogenesis
response to hydroperoxide
voluntary musculoskeletal movement
positive regulation of single strand break repair
replication-born double-strand break repair via sister chromatid exchange
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7515
22594
Ensembl
ENSG00000073050
ENSMUSG00000051768
UniProt
P18887
Q60596
RefSeq (mRNA)
NM_006297
NM_009532 NM_001360168 NM_001360169 NM_001360170
RefSeq (protein)
NP_006288
NP_033558 NP_001347097 NP_001347098 NP_001347099
Location (UCSC)
Chr 19: 43.54 – 43.58 Mb
Chr 7: 24.25 – 24.27 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DNA repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved in DNA repair, where it complexes with DNA ligase III.
^ abcGRCh38: Ensembl release 89: ENSG00000073050 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000051768 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved...
several mammalian short-patch proteins, including pol β, DNA ligase III, XRCC1, and the kinase domain of PNKP. The recent discovery that the poly-A polymerase...
stable complex with the DNA repair protein XRCC1. These proteins interact via their C-terminal BRCT domains. XRCC1 has no enzymatic activity but instead appears...
(FEN1) to remove overhanging flaps. This is followed by recruitment of XRCC1–LIG3 to the site for ligating the DNA ends, leading to an intact DNA. MMEJ...
PES1 REV1; RFC1; TOPBP1; TP53BP1; XRCC1 Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein...
determined. DNA polymerase beta has been shown to interact with PNKP and XRCC1. POLA1 POLA2 GRCm38: Ensembl release 89: ENSMUSG00000031536 – Ensembl, May...
the Okazaki fragments. DNA ligase III: complexes with DNA repair protein XRCC1 to aid in sealing DNA during the process of nucleotide excision repair and...
repair likely employs the process of non-homologous end joining involving XRCC1 and PARP1 proteins that are expressed in Sertoli cells. Sertoli cells have...
Albanes, Demetrius (2003). "Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer amongmale smokers in...
(inherited) polymorphisms of the DNA repair genes ERCC1, ERCC2 (XPD) and XRCC1 increase the risk of glioma. This indicates that altered or deficient repair...
via translocation. DNA ligase I and Flap endonuclease 1 or the Ligase-III-XRCC1 complex seal the nicks to complete NER. The process of nucleotide excision...
PARP1 has been shown to interact with: APTX MYBL2 RELA P53 POLA1 POLA2 XRCC1 ZNF423 DNA damage theory of aging Maximum lifespan Olaparib – a PARP inhibitor...
RFC2 RFC3 RFC4 RFC5 Ubiquitin C Werner syndrome ATP-dependent helicase XRCC1 Y box binding protein 1 Proteins interacting with PCNA via APIM include...
MP, Bohr VA (2015). "Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke...
interfere with DNA repair. APTX is recruited to DNA single-strand breaks by XRCC1 protein, where it functions as a nick sensor to scan the single-strand breaks...
The short patch repair pathway employs POLB (DNA polymerase beta), APE1, XRCC1, PARP1 with the addition of either the LIG1 or LIG3 genes. When an insertion...
also inhibit PARP2, e.g. niraparib. PARP2 has been shown to interact with XRCC1. PARP2 also interacts with HPF1. PARP2 binds to and bridges blunt DNA ends...
sequences. PNKP has been shown to interact with DNA polymerase beta and XRCC1. The human gene encoding PNKP was observed to be mutated in patients with...
found that cadmium caused repression of three of the DNA repair genes: XRCC1 needed for base excision repair, OGG1 needed for base excision repair, and...
deficiencies. These include deficiencies in PALB2, FANCD2, RAD51, ATM, MRE11, p53, XRCC1 and LSD1. ARID1A, a chromatin modifier, is required for non-homologous end...
shown to interact with MUTYH, Flap structure-specific endonuclease 1 and XRCC1. Deficiency of APEX1 causes accummulation of DNA damage leading to both...
OGG1 regulates. Oxoguanine glycosylase has been shown to interact with XRCC1 and PKC alpha. OGG1 may be associated with cancer risk in BRCA1 and BRCA2...
theory of aging). Aprataxin has been shown to interact with: PARP1, P53, XRCC1, and XRCC4. GRCh38: Ensembl release 89: ENSG00000137074 – Ensembl, May 2017...
development of schizophrenia. In particular, the base excision repair protein XRCC1 has been implicated. The most consistent finding in post-mortem examinations...
Global Information
