Phenylalanyl-tRNA synthetase from Thermus thermophilus complexed with tRNA and a phenylalanyl-adenylate analog
Identifiers
Symbol
B5
Pfam
PF03484
InterPro
IPR005147
PROSITE
PDOC00464
SCOP2
1qq3 / SCOPe / SUPFAM
TCDB
5.A.4
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, Domain B5 is found in phenylalanine-tRNA synthetase beta subunits. This domain has been shown to bind DNA through a winged helix-turn-helix motif.[1] Phenylalanine-tRNA synthetase may influence common cellular processes via DNA binding, in addition to its aminoacylation function.
^Dou X, Limmer S, Kreutzer R (January 2001). "DNA-binding of phenylalanyl-tRNA synthetase is accompanied by loop formation of the double-stranded DNA". J. Mol. Biol. 305 (3): 451–8. doi:10.1006/jmbi.2000.4312. PMID 11152603.
In molecular biology, DomainB5 is found in phenylalanine-tRNA synthetase beta subunits. This domain has been shown to bind DNA through a winged helix-turn-helix...
protein followed soon thereafter by the Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domainproteins. Proteins that...
of cytochrome b5-like proteins includes (besides cytochrome b5 itself) hemoprotein domains covalently associated with other redox domains in flavocytochrome...
Pea protein is a food product and protein supplement derived and extracted from yellow and green split peas, Pisum sativum. It can be used as a dietary...
cytochrome b5 reductase aids in the control of iron in red blood cells, which dictates the amount of oxygen cells carry. Cytochromes are redox proteins that...
Pantothenic acid (vitamin B5) is a B vitamin and an essential nutrient. All animals need pantothenic acid in order to synthesize coenzyme A (CoA), which...
factors per gene. There are approximately 2800 proteins in the human genome that contain DNA-binding domains, and 1600 of these are presumed to function...
known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often...
by the CYP come from cytochrome b5. FMN/Fd/P450 systems originally found in Rhodococcus species, in which a FMN-domain-containing reductase is fused to...
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates...
signal in the 3'-untranslated region of the gene. The protein encoded by the CYB5R3 gene is cytochrome b5 reductase, a flavoprotein that is produced as two...
polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules. The name of...
Huntington's disease. Abnormalities of a protein that interacts with the KID domain of CREB, the CREB-binding protein, (CBP) is associated with Rubinstein-Taybi...
mutated in animals. The homeobox domain was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved...
a cytochrome-b5-like domain, several potential phosphorylation sites, and a ZZ-type zinc finger motif. This is likely involved in protein binding, and...
the protein structure of the domain. Forkhead proteins are a subgroup of the helix-turn-helix class of proteins. Many genes encoding FOX proteins have...
Human genes encoding cytochrome b proteins include: CYB5A – cytochrome b5 type A (microsomal) CYB5B – cytochrome b5 type B (outer mitochondrial membrane)...
molecules for example by hydroxylating leukotriene B4 to 20-hydroxy-leukotriene B5, 5-hydroxyeicosatetraenoic acid to 5,20-dihydroxyeicosatetraenoic acid,...
have well-conserved homeodomains. The Pou domain is a bipartite DNA binding domain found in these proteins. The acronym POU is derived from the names...
The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several...
located on chromosome 17. NF1 codes for neurofibromin, a GTPase-activating protein that negatively regulates RAS/MAPK pathway activity by accelerating the...
and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone...