Family of transcription factors involved in anatomical development
FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development.[1][2] FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes.[3]
The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acids forming a motif that binds to DNA. This forkhead motif is also known as the winged helix, due to the butterfly-like appearance of the loops in the protein structure of the domain.[4] Forkhead proteins are a subgroup of the helix-turn-helix class of proteins.
^Lehmann OJ, Sowden JC, Carlsson P, Jordan T, Bhattacharya SS (2003). "Fox's in development and disease". Trends in Genetics. 19 (6): 339–344. doi:10.1016/S0168-9525(03)00111-2. PMID 12801727.
the protein structure of the domain. Forkhead proteins are a subgroup of the helix-turn-helix class of proteins. Many genes encoding FOXproteins have...
human genome and are found in numerous proteins which bind RNA molecules. NeuN/Fox-3 and the other Foxproteins function in the regulation of mRNA splicing...
the same chromosome. 14-3-3 protein family Achaete-scute complex (neuroblast formation) FOXproteins (forkhead box proteins) Families containing homeobox...
tissues. While the precise control mechanism has not yet been established, FOXproteins belong to the forkhead/winged-helix family of transcriptional regulators...
known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene. DMRT1 is a dose sensitive transcription factor protein that regulates Sertoli...
protein followed soon thereafter by the Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domain proteins. Proteins that...
element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented...
similar structure in a wide range of DNA-binding proteins (e.g., cro and repressor proteins, homeodomain proteins, etc.). One of the principal differences between...
belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced...
FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. It is expressed in the...
RNA to be translated into protein when 5' cap-dependent translation is inhibited, such as during viral infection. Myc proteins are transcription factors...
are one of the common types of protein along with soluble globular proteins, fibrous proteins, and disordered proteins. They are targets of over 50% of...
mitochondrial membrane is accomplished by dedicated transport proteins; however no such proteins exist for oxaloacetate. Therefore, in species that lack intra-mitochondrial...
multi-domain proteins. They are sometimes considered as a separate class of proteins along with globular, fibrous and membrane proteins. IDPs are a very...
ultimately protein synthesis. 2. Transcriptional Coactivators and Corepressors: Steroid hormone receptors recruit coactivator or corepressor proteins to the...
largest bats in the world. They are commonly known as fruit bats or flying foxes, among other colloquial names. They live in South Asia, Southeast Asia,...
Homozygous mutant embryos for both Foxproteins failed to form somites 1–8, which indicates the importance of these proteins early on in somite development...
acetylation or deacetylation of histone proteins. The transcription factor can either do this directly or recruit other proteins with this catalytic activity. Many...
consists of one or more ribosomal RNA molecules and many ribosomal proteins (r-proteins). The ribosomes and associated molecules are also known as the translational...
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