Cytochrome B5 (rat) bound to its cofactor. Haem in black, iron in orange and iron-binding histidine residues shown as sticks. (PDB: 1ICC)
Identifiers
Symbol
CYB5A
Alt. symbols
CYB5
NCBI gene
1528
HGNC
2570
OMIM
250790
PDB
1JEX
RefSeq
NM_001914
UniProt
P00167
Other data
Locus
Chr. 18 q23
Search for
Structures
Swiss-model
Domains
InterPro
Cytochrome b5
Identifiers
Symbol
Cyt_B5
Pfam
PF00173
InterPro
IPR001199
PROSITE
PDOC00170
Membranome
211
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Cytochromes b5 are ubiquitous electron transport hemoproteins found in animals, plants, fungi and purple phototrophic bacteria. The microsomal and mitochondrial variants are membrane-bound, while bacterial and those from erythrocytes and other animal tissues are water-soluble. The family of cytochrome b5-like proteins includes (besides cytochrome b5 itself) hemoprotein domains covalently associated with other redox domains in flavocytochrome cytochrome b2 (L-lactate dehydrogenase; EC 1.1.2.3), sulfite oxidase (EC 1.8.3.1), plant and fungal nitrate reductases (EC 1.7.1.1, EC 1.7.1.2, EC 1.7.1.3), and plant and fungal cytochrome b5/acyl lipid desaturase fusion proteins.
Cytochromesb5 are ubiquitous electron transport hemoproteins found in animals, plants, fungi and purple phototrophic bacteria. The microsomal and mitochondrial...
Cytochrome-b5 reductase is a NADH-dependent enzyme that converts ferricytochrome from a Fe3+ form to a Fe2+ form. It contains FAD and catalyzes the reaction:...
electrons are transferred from NADPH via cytochrome P450 reductase (variously CPR, POR, or CYPOR). Cytochromeb5 (cyb5) can also contribute reducing power...
Classification System Cytochromeb5, ubiquitous electron transport hemoproteins Cytochromeb5, type A, a human microsomal cytochromeb5 HLA-B5, an HLA-B serotype...
Cytochromeb5 deficiency is a rare condition and form of isolated 17,20-lyase deficiency caused by deficiency in cytochromeb5, a small hemoprotein that...
atovaquone. Human genes encoding cytochrome b proteins include: CYB5A – cytochromeb5 type A (microsomal) CYB5B – cytochromeb5 type B (outer mitochondrial...
vulnerable to exposure of high levels of nitrates in drinking water Cytochromeb5 reductase deficiency G6PD deficiency Hemoglobin M disease Pyruvate kinase...
age have lower levels of a key methemoglobin reduction enzyme (NADH-cytochromeb5 reductase) in their red blood cells. This results in a major risk of...
(November 1977). "Effect of modification of individual cytochrome c lysines on the reaction with cytochromeb5". Biochemistry. 16 (23): 4975–8. doi:10.1021/bi00642a006...
NADH-cytochromeb5 reductase 3 is an enzyme that in humans is encoded by the CYB5R3 gene. The CYB5R3 gene is located on the 22nd chromosome, with its...
Diaphorase may refer to: Cytochromeb5 reductase, an enzyme NADH dehydrogenase, an enzyme NADPH dehydrogenase, an enzyme This set index page lists enzyme...
cyanosis. The most common congenital cause is a deficiency in the enzyme cytochromeb5 reductase which reduces methemoglobin in the blood. However, in infants...
methaemoglobinaemia associated with decreased activity of erythrocyte cytochromeb5 reductase". Journal of Medical Genetics. 20 (4): 307–309. doi:10.1136/jmg...
Cytochromeb5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene. NCB5OR is a flavohemoprotein that contains functional domains found...
NADH-cytochromeb5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene. The CYB5R1 gene is located on the 1st chromosome, with its specific...
; Takesue, S. (1976-02-16). "Immunological similarity between NADH-cytochromeb5 reductase of erythrocytes and liver microsomes". Biochimica et Biophysica...
of PGRMC1 is heme-binding. PGRMC1 shares key structural motifs with cytochromeb5. PGRMC1 binds and activates P450 proteins, which are important in drug...
Cytochromeb5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene. GRCh38: Ensembl release 89: ENSG00000166394 – Ensembl, May 2017 GRCm38:...
for cytochromes and enzymes, as well as to describe individual protein-bound heme groups (for example, cytochrome bc, and aa3 complexes, cytochromeb5, heme...
addition to these HERC family hallmarks, it has several other motifs; a cytochrome-b5-like domain, several potential phosphorylation sites, and a ZZ-type...
catalyzed by a complex of three membrane-bound enzymes (NADH-cytochromeb5 reductase, cytochromeb5, and a desaturase). These enzymes allow molecular oxygen...
Piracetam, while in the brain, appears to increase the synthesis of cytochromeb5, which is a part of the electron transport mechanism in mitochondria...
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