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Cytochrome b5 reductase information


cytochrome-b5 reductase
Ribbon diagram of erythrocytic methemoglobin reductase with FAD bound. From PDB: 1UMK​.
Identifiers
EC no.1.6.2.2
CAS no.9032-25-1
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MetaCycmetabolic pathway
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Cytochrome b5 reductase

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Cytochrome-b5 reductase is a NADH-dependent enzyme that converts ferricytochrome from a Fe3+ form to a Fe2+ form. It contains FAD and catalyzes the reaction:...

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Cytochrome b5

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1.6.2.2 cytochrome-b5 reductase NADH + H+ + 2 ferricytochrome b5 → NAD+ + 2 ferrocytochrome b5 EC 1.10.2.1 L-ascorbate—cytochrome-b5 reductase L-ascorbate...

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Cytochrome P450

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system after being reduced by cytochrome b5 reductase (CYB5R). Mitochondrial P450 systems which employ adrenodoxin reductase and adrenodoxin to transfer...

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Cytochrome P450 reductase

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Cytochrome P450 reductase (also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase...

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Methemoglobinemia

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systems, e.g., NADH methemoglobin reductase (cytochrome-b5 reductase) (major pathway), NADPH methemoglobin reductase (minor pathway) and to a lesser extent...

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Methemoglobin

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vulnerable to exposure of high levels of nitrates in drinking water Cytochrome b5 reductase deficiency G6PD deficiency Hemoglobin M disease Pyruvate kinase...

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Blue baby syndrome

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The most common congenital cause is a deficiency in the enzyme cytochrome b5 reductase which reduces methemoglobin in the blood. However, in infants the...

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Flavoprotein pyridine nucleotide cytochrome reductases

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ferredoxin-NADP+ reductases, plant and fungal NAD(P)H:nitrate reductases, cytochrome b5 reductases, cytochrome P450 reductases, sulphite reductases, nitric oxide...

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CYB5R3

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NADH-cytochrome b5 reductase 3 is an enzyme that in humans is encoded by the CYB5R3 gene. The CYB5R3 gene is located on the 22nd chromosome, with its...

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Cytochrome b

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prokaryotes, cytochrome b is a component of respiratory chain complex III (EC 1.10.2.2) — also known as the bc1 complex or ubiquinol-cytochrome c reductase. In...

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Cytochrome b5 deficiency

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and/or methemoglobinemia, similarly to deficiency of cytochrome b5 reductase (methemoglobin reductase). Mark A. Sperling (10 April 2014). Pediatric Endocrinology...

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Psyllium

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Takesue, S. (1976-02-16). "Immunological similarity between NADH-cytochrome b5 reductase of erythrocytes and liver microsomes". Biochimica et Biophysica...

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CYB5R1

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NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene. The CYB5R1 gene is located on the 1st chromosome, with its specific...

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CYB5R2

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Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene. GRCh38: Ensembl release 89: ENSG00000166394 – Ensembl, May 2017 GRCm38:...

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Phenazopyridine

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methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase". Journal of Medical Genetics. 20 (4): 307–309. doi:10.1136/jmg...

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CYB5R4

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Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene. NCB5OR is a flavohemoprotein that contains functional domains found...

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Cytochrome c

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Complexes III (Coenzyme Q – Cyt c reductase) and IV (Cyt c oxidase). Cytochrome c is highly water-soluble, unlike other cytochromes. It is capable of undergoing...

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Diaphorase

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Diaphorase may refer to: Cytochrome b5 reductase, an enzyme NADH dehydrogenase, an enzyme NADPH dehydrogenase, an enzyme This set index page lists enzyme...

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Nitrate

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they drink more water per body weight, they have a lower NADH-cytochrome b5 reductase activity, and they have a higher level of fetal hemoglobin which...

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Hemoglobin M disease

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methemoglobinemia. For other congenital subtypes of methemoglobinemia, cytochrome b5 reductase (CYB5R) deficiency is the major cause, rendering defective conversion...

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Fatty acid synthesis

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catalyzed by a complex of three membrane-bound enzymes (NADH-cytochrome b5 reductase, cytochrome b5, and a desaturase). These enzymes allow molecular oxygen...

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Primaquine

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include nausea, vomiting, and stomach cramps. In persons with cytochrome b5 reductase deficiency, primaquine causes methemoglobinemia, a condition in...

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