DMRT1 information

DMRT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YJ0
Identifiers
Aliases	DMRT1, CT154, DMT1, doublesex and mab-3 related transcription factor 1
External IDs	OMIM: 602424; MGI: 1354733; HomoloGene: 9280; GeneCards: DMRT1; OMA:DMRT1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	969,090 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	25,581,693 bp
RNA expression pattern
	Top expressed in
	placenta; ; thyroid gland; ; left lobe of thyroid gland; ; human musculoskeletal system; ; muscular system; ; muscle; ; lymph node; ; muscle; ; muscle of leg; ; lower leg;
	Top expressed in
	seminiferous tubule; ; Sertoli cell; ; spermatogonium; ; spermatid; ; morula; ; spermatocyte; ; respiratory epithelium; ; olfactory epithelium; ; ovary; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; metal ion binding; protein heterodimerization activity; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; protein homodimerization activity; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	cell differentiation; intracellular signal transduction; male gonad development; regulation of transcription, DNA-templated; regulation of nodal signaling pathway; Sertoli cell differentiation; positive regulation of meiosis I; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; male sex determination; negative regulation of meiotic nuclear division; Sertoli cell development; oocyte development; transcription, DNA-templated; multicellular organism development; developmental process involved in reproduction; male germ cell proliferation; male sex differentiation; cell morphogenesis; spermatogenesis; positive regulation of mitotic nuclear division; positive regulation of male gonad development; germ cell migration; positive regulation of transcription by RNA polymerase II; sex differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1761
	50796
	ENSG00000137090
	ENSMUSG00000024837
	Q9Y5R6
	Q9QZ59
	NM_021951; NM_001363767
	NM_015826
	NP_068770; NP_001350696
	NP_056641
	Wikidata
View/Edit Human	View/Edit Mouse

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137090 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024837 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: DMRT1 doublesex and mab-3 related transcription factor 1".
^ Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). "Evidence for evolutionary conservation of sex-determining genes". Nature. 391 (6668): 691–5. Bibcode:1998Natur.391..691R. doi:10.1038/35618. PMID 9490411. S2CID 11414843.
^ Raymond CS, Parker ED, Kettlewell JR, Brown LG, Page DC, Kusz K, Jaruzelska J, Reinberg Y, Flejter WL, Bardwell VJ, Hirsch B, Zarkower D (June 1999). "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators". Hum. Mol. Genet. 8 (6): 989–96. doi:10.1093/hmg/8.6.989. PMID 10332030.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137090 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024837 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DMRT1 doublesex and mab-3 related transcription factor 1".

[pmid9490411-6] Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). "Evidence for evolutionary conservation of sex-determining genes". Nature. 391 (6668): 691–5. Bibcode:1998Natur.391..691R. doi:10.1038/35618. PMID 9490411. S2CID 11414843.

[pmid10332030-7] Raymond CS, Parker ED, Kettlewell JR, Brown LG, Page DC, Kusz K, Jaruzelska J, Reinberg Y, Flejter WL, Bardwell VJ, Hirsch B, Zarkower D (June 1999). "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators". Hum. Mol. Genet. 8 (6): 989–96. doi:10.1093/hmg/8.6.989. PMID 10332030.

DMRT1 information

and 16 Related for: DMRT1 information

DMRT1

XY gonadal dysgenesis

Platypus

Paramesonephric duct

Development of the gonads

Mesonephric duct

Development of the reproductive system

Talpidae

List of human transcription factors

Animal clitoris

Transdifferentiation

Primordial germ cell migration

Through the Wormhole

Monosomy 9p

Haplodiploidy

Cynoglossus semilaevis