Azaperone information

Azaperone
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IM
ATCvet code	QN01AX91 (WHO) QN05AD90 (WHO);
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	4 hours
Identifiers
	IUPAC name 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one;
CAS Number	1649-18-9 ;
PubChem CID	15443;
DrugBank	DB11376;
ChemSpider	14695 ;
UNII	19BV78AK7W;
KEGG	D02620 ;
ChEBI	CHEBI:88301 ;
ChEMBL	ChEMBL340211 ;
CompTox Dashboard (EPA)	DTXSID2045361 ;
ECHA InfoCard	100.015.197
Chemical and physical data
Formula	C19H22FN3O
Molar mass	327.403 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	90 to 95 °C (194 to 203 °F)
	SMILES Fc1ccc(cc1)C(=O)CCCN3CCN(c2ncccc2)CC3;
	InChI InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2 ; Key:XTKDAFGWCDAMPY-UHFFFAOYSA-N ;
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Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.^[1] It is uncommonly used in humans as an antipsychotic drug.

Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression.

^ Posner LP, Burns P (2013). "Sedative agents: tranquilizers, alpha-2 agonists, and related agents. Veterinary pharmacology and therapeutics. 2009:.". In Riviere JE, Papich MG (eds.). Veterinary Pharmacology and Therapeutics (9th ed.). Somerset: Wiley. pp. 337–380 (366). ISBN 978-1-118-68590-7.

[1] Posner LP, Burns P (2013). "Sedative agents: tranquilizers, alpha-2 agonists, and related agents. Veterinary pharmacology and therapeutics. 2009:.". In Riviere JE, Papich MG (eds.). Veterinary Pharmacology and Therapeutics (9th ed.). Somerset: Wiley. pp. 337–380 (366). ISBN 978-1-118-68590-7.

Azaperone information

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Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	IM
ATCvet code	QN01AX91 (WHO) QN05AD90 (WHO)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	4 hours
Identifiers
IUPAC name 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one
CAS Number	1649-18-9^N
PubChem CID	15443
DrugBank	DB11376
ChemSpider	14695^Y
UNII	19BV78AK7W
KEGG	D02620^Y
ChEBI	CHEBI:88301^N
ChEMBL	ChEMBL340211^Y
CompTox Dashboard (EPA)	DTXSID2045361
ECHA InfoCard	100.015.197
Chemical and physical data
Formula	C₁₉H₂₂FN₃O
Molar mass	327.403 g·mol⁻¹
3D model (JSmol)	Interactive image
Melting point	90 to 95 °C (194 to 203 °F)
SMILES Fc1ccc(cc1)C(=O)CCCN3CCN(c2ncccc2)CC3
InChI InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2^Y Key:XTKDAFGWCDAMPY-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)