Acetorphine is a potent opioid analgesic, up to 8700 times stronger than morphine by weight.[1] It is a derivative of the more well-known opioid etorphine, which is used as a very potent veterinary painkiller and anesthetic medication, primarily for the sedation of large animals such as elephants, giraffes and rhinos.
Acetorphine was developed in 1966 by the Reckitt research group that developed etorphine. Acetorphine was developed for the same purpose as etorphine itself, namely as a strong tranquilizer for use in immobilizing large animals in veterinary medicine. Despite showing some advantages over etorphine, for instance producing less toxic side effects in giraffes,[2] acetorphine was never widely adopted for veterinary use, and etorphine (along with other tranquilizers such as carfentanil and azaperone) remains the drug of choice in this application.
^Bentley KW, Hardy DG (June 1967). "Novel analgesics and molecular rearrangements in the morphine-thebaine group. 3. Alcohols of the 6,14-endo-ethenotetrahydrooripavine series and derived analogs of N-allylnormorphine and -norcodeine". Journal of the American Chemical Society. 89 (13): 3281–92. doi:10.1021/ja00989a032. PMID 6042764.
^"The case of etorphine and acetorphine". Bulletin on Narcotics. 1968 (2). UNODC: 51–52. 1968.
Acetorphine is a potent opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of the more well-known opioid etorphine...
Etorphine is illegal, as are the parent compounds Dihydroetorphine and Acetorphine. (Datas from 2022) 6,14-Endoethenotetrahydrooripavine - the central nucleus...
or orders and conditions of licences that may be issued, is illegal. Acetorphine Acetyl-alpha-methylfentanyl Acetyldihydrocodeine Acetylmethadol Alfentanil...
Dihydroetorphine is illegal in Italy, as are its parent compounds etorphine and acetorphine. Thienorphine Carfentanil List of fentanyl analogues Opioid potency comparison...
the Act Brand or street name Drug type Year added Notes and comments Acetorphine opioid 1971 primarily used to sedate elephants, giraffes and rhinos Alfentanil...
effects to the substances already controlled. For instance, etorphine and acetorphine were considered sufficiently morphine-like to fall under the treaty's...
morphine) and acetylation of the 3-hydroxy group of etorphine resulting in acetorphine (8700× morphine)—although while the isopentyl homologue of etorphine...
derivatives of the substances set out in subitems (1) to (4), including: Acetorphine (acetyletorphine) Acetyldihydrocodeine (4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol...
drugs and intermediates are classified as List I drugs of the Opium Law: acetorphine acetyl-alpha-methylfentanyl acetyldihydrocodeine acetylmethadol alphacetylmethadol...
doctors, pharmacists, vets etc. and in other specified circumstances. Acetorphine Acetylmethadol Alfentanil Allylprodine Alphacetylmethadol (i.e. levacetylmethadol)...
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