Peptides released by neurons as intercellular messengers
Neuropeptide Y
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the gut, muscles, and heart.
Neuropeptides are synthesized from large precursor proteins which are cleaved and post-translationally processed then packaged into dense core vesicles. Neuropeptides are often co-released with other neuropeptides and neurotransmitters in a single neuron, yielding a multitude of effects. Once released, neuropeptides can diffuse widely to affect a broad range of targets.
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind...
Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral...
Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled...
NPFF Neuropeptide FF (FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide...
Neuropeptide W or preprotein L8 is a short human neuropeptide. Neuropeptide W acts as a ligand for two neuropeptide B/W receptors, NPBWR1 and NPBWR2,...
The neuropeptide FF receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides...
Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide...
A neuropeptide receptor is a type of peptide receptor which binds one or more neuropeptides. An example is the μ-opioid receptor, which binds to and is...
Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene. Neuropeptide Y (endogenous agonist, non subtype selective) BWX-46...
Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the...
The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS)...
Neuropeptide S (NPS) is a neuropeptide found in human and mammalian brain, mainly produced by neurons in the amygdala and between Barrington's nucleus...
Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene. Neuropeptide Y (endogenous agonist, non subtype selective) Peptide...
GPCR neuropeptide receptors are G-protein coupled receptors which bind various neuropeptides. Members include: Neuropeptide B/W receptor NPBWR1 NPBWR2...
Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is...
Neuropeptide K (also known as neurokinin K), is a protein encoded by the TAC1 gene. It is an elongated derivative of the N-terminus of neurokinin A as...
Putative neuropeptide Y receptor type 6 is a protein that in humans is encoded by the NPY6R gene. GRCh38: Ensembl release 89: ENSG00000226306 – Ensembl...
acetylcholine, histamine, norepinephrine, nitric oxide, and several neuropeptides. Cannabinoids can also be powerful CNS neuromodulators. Neuromodulators...
Neuropeptide FF receptor 1, also known as NPFF1 is a human protein, encoded by the NPFFR1 gene. Neuropeptide FF receptor GRCh38: Ensembl release 89: ENSG00000148734...
Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene. Neuropeptide FF receptor GRCh38: Ensembl release 89: ENSG00000056291...
about 50 residues; a variable-length region; and the sequence of the neuropeptides themselves. Sequence analysis reveals that the conserved N-terminal...
roles both as a neuropeptide in the central nervous system and as a peptide hormone in the gut. It is the most abundant neuropeptide in the central nervous...
precursor for a neuropeptide gene, nesfatin-1, has also been found in Tunicaraptor unikontum. These discoveries suggest that neuropeptide signaling in animals...
Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. Present in animals since...
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