Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Arsenic trioxide is an inorganic compound with the formula As 2O 3.[5] As an industrial chemical, its major uses include the manufacture of wood preservatives, pesticides, and glass.[6] It is sold under the brand name Trisenox among others[2][3] when used as a medication to treat a type of cancer known as acute promyelocytic leukemia.[7] For this use it is given by injection into a vein.[7]
Common side effects include vomiting, diarrhea, swelling, shortness of breath, and headaches.[7] Severe side effects may include APL differentiation syndrome and heart problems.[7] Use during pregnancy or breastfeeding may harm the baby.[8][9] Its mechanism in treating cancer is not entirely clear.[7]
Arsenic trioxide was approved for medical use in the United States in 2000.[7] It is on the World Health Organization's List of Essential Medicines.[10] Approximately 50,000 tonnes are produced a year.[11] Due to its toxicity, a number of countries have regulations around its manufacture and sale.[12]
^Shakhashiri BZ. "Chemical of the Week: Arsenic". University of Wisconsin-Madison Chemistry Dept. Archived from the original on 2 August 2008. Retrieved 3 August 2008.
^ ab"Trisenox- arsenic trioxide injection, solution". DailyMed. 30 June 2022. Retrieved 3 February 2024.
^ ab"Trisenox EPAR". European Medicines Agency. 10 August 2010. Retrieved 3 February 2024.
^"Safety Data Sheet". American Elements. 2021. Retrieved 4 January 2022.
^Sun H (2010). Biological Chemistry of Arsenic, Antimony and Bismuth. John Wiley & Sons. p. 295. ISBN 9780470976227.
^Landner L (2012). Chemicals in the Aquatic Environment: Advanced Hazard Assessment. Springer Science & Business Media. p. 259. ISBN 9783642613340.
^ abcdef"Arsenic Trioxide Monograph for Professionals". Drugs.com. Retrieved 15 November 2019.
^British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 907. ISBN 9780857113382.
^"Arsenic trioxide (Trisenox) Use During Pregnancy". Drugs.com. Retrieved 16 November 2019.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^Grund SC, Hanusch K, Wolf HU. "Arsenic and Arsenic Compounds". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_113.pub2. ISBN 978-3527306732.
^Consolidated List of Products Whose Consumption And/or Sale Have Been Banned, Withdrawn, Severely Restricted Or Not Approved by Governments: Chemicals. United Nations Publications. 2009. p. 24. ISBN 9789211302196.[permanent dead link]
Arsenictrioxide is an inorganic compound with the formula As 2O 3. As an industrial chemical, its major uses include the manufacture of wood preservatives...
the III–V compound semiconductor gallium arsenide. Arsenic and its compounds, especially the trioxide, are used in the production of pesticides, treated...
experiencing a life-threatening heart rhythm problem from arsenictrioxide.[citation needed] Arsenic in cells clearly stimulates the production of hydrogen...
from a mixture of potassium nitrate and arsenictrioxide. Previously Paracelsus heated a mixture of arsenictrioxide and potassium nitrate. He applied the...
improvements, in forensic toxicology until the 1970s. Arsenic, in the form of white arsenictrioxide As 2O 3, was a highly favored poison, being odourless...
oxides, Sb2O3 dissolves in aqueous solutions with hydrolysis. A mixed arsenic-antimony oxide occurs in nature as the very rare mineral stibioclaudetite...
acid, arsenic acid is an oxidizer, as illustrated by its ability to convert iodide to iodine. Arsenic acid is prepared by treating arsenictrioxide with...
(SMO), which are being used for the treatment of basal cell carcinoma. Arsenictrioxide, an inhibitor of GLI transcription factors, is being used for the treatment...
Arsenic oxide may refer to any of the following: Arsenic dioxide, As2O4 Arsenictrioxide, As2O3 Arsenic pentoxide, As2O5 Arsenious oxide, As4O6 This set...
well-characterized. The preparation of As(OH)3 involves a slow hydrolysis of arsenictrioxide in water. Addition of base converts arsenous acid to the arsenite ions...
2013 the standard of treatment for concurrent chemotherapy has become arsenictrioxide, which combined with ATRA is referred to ATRA-ATO; before 2013 the...
readily in air to form arsenictrioxide and water, and analogous reactions take place with sulfur and selenium instead of oxygen. Arsenic forms colorless, odorless...
"effective, long-term management" of arsenictrioxide. Arsenictrioxide dust, which contains approximately 60% arsenic, is highly lethal even in small doses...
systems. Arsenictrioxide is used in the glass industry as a decolourizing and fining agent (for the removal of bubbles), as is antimony trioxide. Tellurium...
arsenicum album (Arsenic. alb.) is a solution prepared by diluting aqueous arsenictrioxide generally until there is little amounts of Arsenic remaining in...
As(V), but not As(III), or arsenictrioxide, which doesn't have a net charge. Effective long-term ion exchange removal of arsenic requires a trained operator...
Arsenic trisulfide is the inorganic compound with the formula As2S3. It is a dark yellow solid that is insoluble in water. It also occurs as the mineral...
Phosphorus trioxide is the chemical compound with the molecular formula P4O6. Although the molecular formula suggests the name tetraphosphorus hexoxide...
reaction of arsenic trichloride and potassium iodide: AsCl3 + 3KI → AsI3 + 3 KCl Hydrolysis occurs only slowly in water forming arsenictrioxide and hydroiodic...
"Safety (MSDS) data for arsenictrioxide". ox.ac.uk. Archived from the original on 2010-03-09. "Safety (MSDS) data for metallic arsenic". ox.ac.uk. Archived...
However, rather than daff, Goddard sold Archer 12 pounds (5.4 kg) of arsenictrioxide. The mistake remained undetected even during manufacture of the sweets...
contaminated with arsenic, which is released in roasting (burning in air). In such processing, arsenide is converted to arsenictrioxide, which is volatile...
titration of solutions, based on their high purity, are provided: Arsenictrioxide for making sodium arsenite solution for standardisation of sodium periodate...
patients who had been treated with another highly efficacious drug, arsenictrioxide, and yet did not appear in patients treated with tretinoin for other...
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