Amine Dehydrogenase (EC 1.4.99.3), also known as methylamine dehydrogenase (MADH), is a tryptophan tryptophylquinone-dependent (TTQ-dependent) enzyme that catalyzes the oxidative deamination of a primary amine to an aldehyde and ammonia. The reaction occurs as follows:
Amine dehydrogenase possesses an α2β2 structure with each smaller β subunit possessing a TTQ protein cofactor.
Amine dehydrogenase, studied in Paracoccus denitrificans, at least transiently forms a ternary complex to catalyze methylamine-dependent cytochrome c-551i reduction. Within this complex, electrons are transferred from the TTQ cofactor of MADH to the Type 1 copper center of amicyanin, and then to the heme of the cytochrome.
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AmineDehydrogenase (EC 1.4.99.3), also known as methylamine dehydrogenase (MADH), is a tryptophan tryptophylquinone-dependent (TTQ-dependent) enzyme that...
modification of amino acids within the protein. Methylamine dehydrogenase (MADH), an aminedehydrogenase, requires TTQ for its catalytic function. Amicyanin Davidson...
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain...
"Stereoselective synthesis of opine-type secondary amine carboxylic acids by a new enzyme opine dehydrogenase. Use of recombinant enzymes". J. Mol. Catal.,...
Azurins support oxidative deamination of primary amines by passing electrons from aromatic aminedehydrogenase to cytochrome oxidase, as well as from some...
deamination that generates α-keto acids and other oxidized products from amine-containing compounds, and occurs primarily in the liver. Oxidative deamination...
for protons has been observed in tryptamine oxidation by aromatic aminedehydrogenase. Quantum tunneling does not appear to provide a major catalytic advantage...
biosynthesis QhpD in post-translational processing of quinohemoprotein aminedehydrogenase RumMC2 in ruminococcin C biosynthesis Radical SAM epimerases are...
makes it a highly appealing method to produce amines in green chemistry. In biochemistry, dehydrogenase enzymes can catalyze the reductive amination of...
respective dehydrogenase. Alternative Mechanism A second type of transamination reaction can be described as a nucleophilic substitution of one amine or amide...
(benzene with two hydroxyl side groups next to each other) and a side-chain amine. Catechol can be either a free molecule or a substituent of a larger molecule...
amide which combines a pyrazole acid with an aryl amine to give an inhibitor of succinate dehydrogenase. The compound is widely registered for use, including...
of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 225–226. Portal:...
catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. They are found bound to the outer membrane of mitochondria in most...
cellular respiration, pyruvate decarboxylation, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation...
cyanoborohydride to give the amine required for amide formation with the acid chloride of the pyrazole. Succinate dehydrogenase inhibitors (SDHI) of this...
phosphothreonine. Phosphothreonine has three potential coordination sites (carboxyl, amine and phosphate group) and determination of the mode of coordination between...
total activity of two enzymes (Glucose-6-phosphate dehydrogenase and 6-Phosphogluconate dehydrogenase) in the pentose phosphate pathway, which is important...
and acyl CoA dehydrogenase. FADH and FADH2 are reduced forms of FAD. FADH2 is produced as a prosthetic group in succinate dehydrogenase, an enzyme involved...
synthesized in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase or a cytoplasmic enzyme of pyrimidine synthesis pathway. It is sometimes...
In enzymology, a formaldehyde dehydrogenase (EC 1.2.1.46) is an enzyme that catalyzes the chemical reaction formaldehyde + NAD+ + H2O ⇌ {\displaystyle...
is an enzyme that reduces imines to amines. This family of enzymes is employed in the industrial production of amine-containing pharmaceuticals. The IRED...
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