Orotic acid (/ɔːˈrɒtɪk/)[1] is a pyrimidinedione and a carboxylic acid. Historically, it was believed to be part of the vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin.
The compound is synthesized in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase[2] or a cytoplasmic enzyme of pyrimidine synthesis pathway. It is sometimes used as a mineral carrier in some dietary supplements (to increase their bioavailability), most commonly for lithium orotate.
^Rawls J, Knecht W, Diekert K, Lill R, Löffler M (April 2000). "Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase". European Journal of Biochemistry. 267 (7): 2079–2087. doi:10.1046/j.1432-1327.2000.01213.x. PMID 10727948.
Oroticacid (/ɔːˈrɒtɪk/) is a pyrimidinedione and a carboxylic acid. Historically, it was believed to be part of the vitamin B complex and was called...
synthesis pathway. Orotic aciduria is characterized by excessive excretion of oroticacid in urine because of the inability to convert oroticacid to UMP. It...
synthesis can lead to the genetic disease Orotic aciduria which causes excessive excretion of oroticacid in the urine. Nucleotides are initially made...
Orotate phosphoribosyltransferase (OPRTase) or oroticacid phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the...
Magnesium orotate, the magnesium salt of oroticacid, is a mineral supplement. It can be used in treating extracellular magnesium deficiency, as well...
pattern. OTC deficiency is also accompanied by hyperammonemia and high oroticacid levels. BUN is usually reported in mg/dL in some countries (e.g. United...
block is proximal to these intermediates) and increased oroticacid. The increased oroticacid concentrations result from the buildup of carbamoyl phosphate...
Lithium orotate (C5H3LiN2O4) is a salt of oroticacid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently...
carbamoyl-phosphate in the cytoplasm to the common precursor ring structure oroticacid, onto which a phosphorylated ribosyl unit is covalently linked. Purines...
result in orotic aciduria, a metabolic disorder. In a study, gerbils fed a combination of uridine monophosphate, choline, and docosahexaenoic acid (DHA) were...
1879, when Grimaux reported the preparation of barbituric acid from urea and malonic acid in the presence of phosphorus oxychloride. The systematic study...
uridine monophosphate synthetic pathway. Oroticacid is a product of this pathway. Increased levels of oroticacid in urine can be an indicator that a patient...
2013. Retrieved 4 November 2013. Chester, DO (1979). "Three New Aliphatic Acids from Lichens of Genus Parmelia (Subgenus Xanthoparmelia )". Australian Journal...
folate ("pteroylmonoglutamic acid" in this nomenclature). Vitamin B13: oroticacid. Vitamin B14: cell proliferant, anti-anemia, rat growth factor, and antitumor...
5-Dihydroorotic acidOroticacid. Note the double bond in the ring. The particular mechanism for the dehydrogenation of dihydroorotic acid by DHODH differs...
of chess Moseley, a suburb of Birmingham, England, from its postcode Oroticacid, formerly known as Vitamin B13 Boron-13 (B-13 or 13B), an isotope of...
"Enzymatic synthesis and breakdown of a pyrimidine, oroticacid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). The Journal...
Orotidine is a nucleoside formed by attaching oroticacid to a ribose ring via a β-N1-glycosidic bond. It is found in bacteria, fungi and plants. It was...
PMID 2767686. Traut TW, Jones ME (1996). Uracil metabolism--UMP synthesis from oroticacid or uridine and conversion of uracil to beta-alanine: enzymes and cDNAs...
effective in accomplishing enzymatic assays for oroticacid in milk (Anastasi et al. 2000) and malic acid in fruits, wines and other beverages and also...
the presence of the condition: Plasma ammonia concentration. Urinary oroticacid concentration Red blood cell arginase enzyme activity (measurement) The...
KORNBERG A (1955). "Enzymatic synthesis and breakdown of a pyrimidine, oroticacid. III Ureidosuccinase". J. Biol. Chem. 212 (2): 909–20. PMID 14353892...
"Enzymatic synthesis and breakdown of a pyrimidine, oroticacid. I Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin". J. Biol. Chem. 207...
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