Chemical compound
This article is about gonadorelin (GnRH) as a medication. For its role as a hormone, see GnRH.
Gonadorelin Trade names Factrel, HRF, Kryptocur, Lutrelef, Lutrepulse, Relefact, others Other names Abbott 41070; AY-24031; Hoe-471; RU-19847 Routes of administration intravenous, subcutaneous[1] Drug class GnRH analogue; GnRH agonist; Progonadotropin ATC code H01CA01 (WHO ) V04CM01 (WHO ) QH01CA01 (WHO ) QV04CM01 (WHO ) Legal status
Metabolism Hydrolysis[1] Elimination half-life 10–40 minutes[1]
(2S )-N -[(2S )-1-[[(2S )-1-[[(2S )-1-[[(2S )-1-[[2-[[(2S )-1-[[(2S )-1-[(2S )-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H -indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H -imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS Number 33515-09-2 71447-49-9 (diacetate) 51952-41-1 (hydrochloride)PubChem CID DrugBank ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) DTXSID20873490 ECHA InfoCard 100.046.852 Formula C 55 H 75 N 17 O 13 Molar mass 1182 .311 g·mol−1 3D model (JSmol)
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6
InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
Key:XLXSAKCOAKORKW-AQJXLSMYSA-N
Gonadorelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which is used in fertility medicine and to treat amenorrhea and hypogonadism.[2] [3] [4] [5] [6] [7] It is also used in veterinary medicine.[3] [5] The medication is a form of the endogenous GnRH and is identical to it in chemical structure.[2] [3] [5] [7] It is given by injection into a blood vessel or fat or as a nasal spray.[5] [1] [7]
^ a b c d "Gonadorelin".
^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. pp. 745–. ISBN 978-1-4757-2085-3 .
^ a b c Index Nominum 2000: International Drug Directory . Taylor & Francis. 2000. pp. 499–. ISBN 978-3-88763-075-1 .
^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms . Springer Science & Business Media. pp. 136–. ISBN 978-94-011-4439-1 .
^ a b c d "Gonadorelin injectable Uses, Side Effects & Warnings".
^ Shao WM, Bai WJ, Chen YM, Liu L, Wang YJ (August 2014). "[Micropump infusion of gonadorelin in the treatment of hypogonadotropic hypogonadism in patients with pituitary stalk interruption syndrome: cases analysis and literature review]". Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences (in Chinese). 46 (4): 642–645. PMID 25131486.
^ a b c Köhn FM, Schill WB (17 July 2017). "Hormone Substitution in Male Infertility". In Allahbadia GN, Chawla MM, Das RB, Garcia EV, Gandhi G, Merchant R (eds.). The Art & Science of Assisted Reproductive Techniques (ART) . JP Medical Ltd. pp. 731–. ISBN 978-93-86322-82-1 .
Last Update: 2023-11-30T07:55:19Z
Gonadorelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which is used in fertility medicine and to treat amenorrhea and hypogonadism. It...
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Last Update: 2024-04-29T18:26:37Z
following classes: Gonadorelin : There are currently five available gonadorelin products that are FDA-Approved. Usually, gonadorelin is used in conjunction...
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castration agent for reducing sexual urges in sex offenders. Triptorelin is a gonadorelin analogue, also known as luteinizing hormone releasing analogue (GnRH...
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inhibitor, progestogen, dopamine agonists, oestrogen, prostaglandins, gonadorelin , clomiphene, tamoxifen, diethylstilbestrol. Emollients, anti-pruritics...
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Progonadotropins Antiandrogens (e.g., bicalutamide) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., FSHTooltip follicle-stimulating hormone...
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Antiestrogens (e.g., tamoxifen, clomifene) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., LHTooltip luteinizing hormone, hCGTooltip...
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Agonists Peptide: Azagly-nafarelin Buserelin Deslorelin Fertirelin Gonadorelin Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin...
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post-partum hemorrhage Choragon / Brevactid (u-hCG) Lutrepulse / Lutrelef (gonadorelin acetate) Norprolac (quinagolide hydrochloride); Rekovelle (follitropin...
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Antiestrogens (e.g., tamoxifen, clomifene) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., LHTooltip luteinizing hormone, hCGTooltip...
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Antiestrogens (e.g., tamoxifen, clomifene) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., LHTooltip luteinizing hormone, hCGTooltip...
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Antiestrogens (e.g., tamoxifen, clomifene) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., LHTooltip luteinizing hormone, hCGTooltip...
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Pancreozymin (cholecystokinin) V04CK03 Bentiromide QV04CV01 Lobeline V04CM01 Gonadorelin V04CX01 Indocyanine green V04CX02 Folic acid V04CX03 Methacholine V04CX04...
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Progonadotropins Antiandrogens (e.g., bicalutamide) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., FSHTooltip follicle-stimulating hormone...
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Last Update: 2024-04-29T04:09:18Z
Progonadotropins Antiandrogens (e.g., bicalutamide) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., FSHTooltip follicle-stimulating hormone...
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Last Update: 2024-05-08T13:03:07Z
Antiestrogens (e.g., tamoxifen, clomifene) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., LHTooltip luteinizing hormone, hCGTooltip...
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Last Update: 2024-03-18T05:57:34Z
Agonists Peptide: Azagly-nafarelin Buserelin Deslorelin Fertirelin Gonadorelin Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin...
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Last Update: 2024-01-13T06:17:14Z
Progonadotropins Antiandrogens (e.g., bicalutamide) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., FSHTooltip follicle-stimulating hormone...
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Last Update: 2024-02-27T04:27:01Z
Progonadotropins Antiandrogens (e.g., bicalutamide) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., FSHTooltip follicle-stimulating hormone...
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Last Update: 2023-12-20T19:22:11Z
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Last Update: 2024-03-31T02:55:33Z
Agonists Peptide: Azagly-nafarelin Buserelin Deslorelin Fertirelin Gonadorelin Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin...
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Last Update: 2024-03-18T23:55:58Z
Progonadotropins Antiandrogens (e.g., bicalutamide) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., FSHTooltip follicle-stimulating hormone...
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Antiestrogens (e.g., tamoxifen, clomifene) GnRH agonists (e.g., GnRH (gonadorelin ), leuprorelin) Gonadotropins (e.g., LHTooltip luteinizing hormone, hCGTooltip...
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Last Update: 2023-09-03T18:25:08Z
Agonists Peptide: Azagly-nafarelin Buserelin Deslorelin Fertirelin Gonadorelin Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin...
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