Drug used in IVF procedures
Cetrorelix Trade names Cetrotide, others AHFS/Drugs.com Monograph Routes of administration Subcutaneous injection Drug class GnRH analogue; GnRH antagonist; Antigonadotropin ATC code Legal status
Bioavailability 85% Protein binding 86% Elimination half-life 62.8 hours / 3 mg single dose; 5 hours / 0.25 mg single dose; 20.6 hours / 0.25 mg multiple doses Excretion feces (5% to 10% as unchanged drug and metabolites); urine (2% to 4% as unchanged drug)
Acetyl-D -3-(2′ -naphtyl)-alanine-D -4-chlorophenylalanine-D -3-(3′ -pyridyl)- alanine-L -serine-L -tyrosine-D -citrulline-L -leucine-L -arginine-L -proline-D -alanine-amide
CAS Number 120287-85-6 Y PubChem CID IUPHAR/BPS DrugBank DB00050 Y ChemSpider 10482082 Y UNII KEGG D07665 Y ChEBI CHEBI:59224 Y ChEMBL ChEMBL1200490 N CompTox Dashboard (EPA ) DTXSID7040996 ECHA InfoCard 100.212.148 Formula C 70 H 92 Cl N 17 O 14 Molar mass 1431 .06 g·mol−1 3D model (JSmol)
CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
InChI=1S/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54+,55-,56-,57+,58+/m1/s1
Y Key:SBNPWPIBESPSIF-MHWMIDJBSA-N
Y
N Y (what is this?) (verify)
Cetrorelix (INN Tooltip International Nonproprietary Name , BAN Tooltip British Approved Name ), or cetrorelix acetate (USAN Tooltip United States Adopted Name , JAN Tooltip Japanese Accepted Name ), sold under the brand name Cetrotide , is an injectable gonadotropin-releasing hormone (GnRH) antagonist. A synthetic decapeptide, it is used in assisted reproduction to inhibit premature luteinizing hormone surges[1] The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In addition, cetrorelix can be used to treat hormone-sensitive cancers of the prostate[citation needed ] and breast (in pre-/perimenopausal women)[citation needed ] and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning).[citation needed ] It is administered as either multiple 0.25 mg daily subcutaneous injections or as a single-dose 3 mg subcutaneous injection. The duration of the 3 mg single dose is four days; if human chorionic gonadotropin (hCG) is not administered within four days, a daily 0.25 mg dose is started and continued until hCG is administered.
It is available as a generic medication.[2] [3]
^ "Cetrotide 0.25 mg" (PDF) . emdserono.com . Archived from the original (PDF) on 5 April 2016. Retrieved 30 January 2016 .
^ "2022 First Generic Drug Approvals". U.S. Food and Drug Administration (FDA) . 3 March 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023 .
^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA) . 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023 .
Last Update: 2023-12-20T19:52:50Z
Cetrorelix (INNTooltip International Nonproprietary Name, BANTooltip British Approved Name), or cetrorelix acetate (USANTooltip United States Adopted Name...
Word Count : 785
Last Update: 2024-04-13T07:57:42Z
GnRH agonists (e.g., leuprorelin, goserelin) GnRH antagonists (e.g., cetrorelix , elagolix) Progestogens (e.g., chlormadinone acetate, cyproterone acetate...
Word Count : 7575
Last Update: 2024-04-10T17:44:41Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 7428
Last Update: 2024-04-30T18:23:00Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 4374
Last Update: 2023-09-18T18:23:21Z
GnRH agonists (e.g., goserelin, leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (e.g., chlormadinone acetate, cyproterone acetate, gestonorone...
Word Count : 254
Last Update: 2024-05-08T13:03:07Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 1331
Last Update: 2024-04-29T04:09:18Z
GnRH agonists (e.g., leuprorelin, goserelin) GnRH antagonists (e.g., cetrorelix , elagolix) Progestogens (e.g., chlormadinone acetate, cyproterone acetate...
Word Count : 24526
Last Update: 2024-03-18T14:50:10Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 6821
Last Update: 2024-03-22T02:54:27Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 2274
Last Update: 2024-04-01T21:52:54Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 18252
Last Update: 2024-05-08T12:58:59Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 3293
Last Update: 2024-05-02T01:46:11Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 21566
Last Update: 2024-05-08T19:15:55Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 15672
Last Update: 2023-11-30T07:55:19Z
(leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 814
Last Update: 2024-02-09T06:23:57Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 9305
Last Update: 2024-01-13T06:17:14Z
GnRH agonists (e.g., leuprorelin, goserelin) GnRH antagonists (e.g., cetrorelix , elagolix) Progestogens (e.g., chlormadinone acetate, cyproterone acetate...
Word Count : 2051
Last Update: 2023-12-20T19:22:11Z
(leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 934
Last Update: 2024-03-18T23:55:58Z
GnRH agonists (e.g., leuprorelin, goserelin) GnRH antagonists (e.g., cetrorelix , elagolix) Progestogens (e.g., chlormadinone acetate, cyproterone acetate...
Word Count : 9431
Last Update: 2024-02-19T21:26:22Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 542
Last Update: 2024-04-17T19:36:57Z
(leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 3474
Last Update: 2024-02-02T08:12:19Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 1682
Last Update: 2024-03-08T17:44:43Z
paroxypropione) GnRH agonists (e.g., leuprorelin) GnRH antagonists (e.g., cetrorelix ) Progestogens (incl., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone...
Word Count : 2061