"Hormone blocker" redirects here. For testosterone blockers, see Antiandrogen. For estrogen blockers, see Aromatase inhibitor.
Puberty blockers (also called puberty inhibitors or hormone blockers) are medicines used to postpone puberty in children. The most commonly used puberty blockers are gonadotropin-releasing hormone (GnRH) agonists, which suppress the natural production of sex hormones, such as androgens (e.g. testosterone) and estrogens (e.g. estradiol).[1][2][3] Puberty blockers are used to delay the development of unwanted secondary sex characteristics in transgender children,[4] so as to allow transgender youth more time to explore their gender identity.[5] The same drugs are also used to treat other conditions, such as precocious puberty in young children and some hormone-sensitive cancers in adults.[6][7][8]
The use of puberty blockers in transgender youth is supported by twelve major American medical associations, including the American Medical Association,[9] the American Psychological Association,[10] the American Academy of Pediatrics,[11] along with four Australian medical organizations,[12] the Endocrine Society,[13] the European Society for Sexual Medicine,[14]:573 and the World Professional Association for Transgender Health (WPATH).[15]
As of 2024[update], the provision of puberty blockers for gender dysphoria in children has become the subject of public controversy. A combination of shifts in public opinion, political lobbying,[citation needed] and scepticism from some in the field of medicine has led to the rolling back of the use of puberty blockers for transgender children in several countries, with results ranging from some health systems stopping the routine use of puberty blockers until higher-quality research evidence is available,[16] to the provision of puberty blockers to children being made a criminal offence in some states of the United States.[17][18]
^Hemat RA (2 March 2003). Andropathy. Urotext. pp. 120–. ISBN 978-1-903737-08-8.
^Becker KL (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 973–. ISBN 978-0-7817-1750-2.
^"Pubertal blockers for transgender and gender diverse youth". Mayo Clinic. 16 August 2019. Retrieved 15 December 2020.
^Stevens J, Gomez-Lobo V, Pine-Twaddell E (December 2015). "Insurance Coverage of Puberty Blocker Therapies for Transgender Youth". Pediatrics. 136 (6): 1029–31. doi:10.1542/peds.2015-2849. PMID 26527547.
^Alegría CA (October 2016). "Gender nonconforming and transgender children/youth: Family, community, and implications for practice". Journal of the American Association of Nurse Practitioners. 28 (10): 521–527. doi:10.1002/2327-6924.12363. PMID 27031444. S2CID 22374099.
^Helyar, Sinead; Jackson, Laura; Patrick, Leanne; Hill, Andy; Ion, Robin (May 2022). "Gender Dysphoria in children and young people: The implications for clinical staff of the Bell V's Tavistock Judicial Review and Appeal Ruling". Journal of Clinical Nursing. 31 (9–10): e11–e13. doi:10.1111/jocn.16164. PMID 34888970. S2CID 245029743.
^Watson SE, Greene A, Lewis K, Eugster EA (June 2015). "Bird's-eye view of GnRH analog use in a pediatric endocrinology referral center". Endocrine Practice. 21 (6): 586–9. doi:10.4158/EP14412.OR. PMC 5344188. PMID 25667370.
^Panday K, Gona A, Humphrey MB (October 2014). "Medication-induced osteoporosis: screening and treatment strategies". Therapeutic Advances in Musculoskeletal Disease. 6 (5): 185–202. doi:10.1177/1759720X14546350. PMC 4206646. PMID 25342997.
^"March 26, 2021: State Advocacy Update". 26 March 2021.
^"Endocrine Society opposes legislative efforts to prevent access to medical care for transgender youth". 15 April 2021.
^T'Sjoen, Guy; Arcelus, Jon; De Vries, Annelou L.C.; Fisher, Alessandra D.; Nieder, Timo O.; Özer, Müjde; Motmans, Joz (1 April 2020). "European Society for Sexual Medicine Position Statement "Assessment and Hormonal Management in Adolescent and Adult Trans People, with Attention for Sexual Function and Satisfaction"". The Journal of Sexual Medicine. 17 (4): 570–584. doi:10.1016/j.jsxm.2020.01.012. hdl:1854/LU-8660203. ISSN 1743-6109.
^Cite error: The named reference :0 was invoked but never defined (see the help page).
^Choi, Annette; Mullery, Will (6 June 2023). "19 states have laws restricting gender-affirming care, some with the possibility of a felony charge". CNN. Retrieved 17 September 2023.
^Alfonseca, Kiara (22 May 2023). "Map: Where gender-affirming care is being targeted in the US". ABC News. Retrieved 14 August 2023.
Pubertyblockers (also called puberty inhibitors or hormone blockers) are medicines used to postpone puberty in children. The most commonly used puberty...
found that there was very low certainty of quality of evidence about pubertyblocker outcomes in terms of mental health, quality of life and impact on gender...
the Court of Appeal (England and Wales) on the question of whether pubertyblockers could be prescribed to under-16s with gender dysphoria. The Court of...
therapy in transgender women, as a pubertyblocker to prevent puberty in transgender girls and to treat early puberty in boys, and the treatment of long-lasting...
Health and Care Excellence, concluding that the quality of evidence for pubertyblocker outcomes (for mental health, quality of life and impact on gender dysphoria)...
appointment. In 2010–11, the GIDS lowered the age of prescription for the pubertyblocker drug from 15 to 10 years old after facing pressure from activists and...
transitioning at 12 years old. In February 2018, she was prescribed the pubertyblocker Lupron at age 13. A month later, she started testosterone injections...
supportive mental health care, social transition, and/or pubertyblockers, which delay puberty and the development of secondary sex characteristics to...
James (16 April 2024). "Humza Yousaf responds to calls for children's pubertyblocker ban in Scotland". The National. Archived from the original on 18 April...
component of feminizing hormone therapy for transgender women and as pubertyblockers in transgender girls. Side effects of antiandrogens depend on the type...
transgender activism endangers women, and he has likened the use of pubertyblockers to Nazi eugenics. Linehan says his views have lost him work and ended...
different mechanism of action. It can also be used as a pubertyblocker in the case of precocious puberty. Triptorelin has been used as a chemical castration...
Cohen D, Barnes H (September 2019). "Gender dysphoria in children: pubertyblockers study draws further criticism". BMJ. 366: l5647. doi:10.1136/bmj.l5647...
on PubertyBlockers Mucked Up the Most Important Point About Them". Slate. Wulfsohn, Joseph A. (November 15, 2022). "New York Times story on puberty blockers...
Wales could not consent to pubertyblockers, with NHS England consequently stating that any requirement for pubertyblockers would have to be brought through...
Transsexual Health care and medicine Gender dysphoria in children Pubertyblocker Hormone therapy feminizing masculinizing DIY hormone therapy Surgery...
Retrieved 24 October 2023. {{cite web}}: |last= has generic name (help) "Puberty-blocker drug firm donated cash to Lib Dems". The Times. 8 December 2019. Archived...
It is also used off-label for the treatment of precocious puberty, as a pubertyblocker in transgender children, and as a component of transgender hormone...
February 2023, South Dakota passed a law prohibiting hormone therapy, pubertyblockers, and several gender affirming surgeries for minors. Arkansas: On March...
Transsexual Health care and medicine Gender dysphoria in children Pubertyblocker Hormone therapy feminizing masculinizing DIY hormone therapy Surgery...
stimulation in in vitro fertilization (IVF). Nafarelin is used as a pubertyblocker in transgender youth and to suppress testosterone levels in transgender...
June 2023. Retrieved 6 January 2024. Hill, Ruth (29 September 2022). "Pubertyblocker use jumps as expert backs results". RNZ. Archived from the original...
endometriosis, uterine fibroids, as part of transgender hormone therapy, for early puberty, or to perform chemical castration of violent sex offenders. It is given...
state agencies to treat gender-affirming medical treatments (such as pubertyblockers or hormone treatments) for transgender youths as child abuse. She has...
of a 12-year-old trans girl might be able to get a prescription for pubertyblockers, following the reporters having two appointments with a counsellor...
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