APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide") is a family of evolutionarily conserved cytidine deaminases. A mechanism of generating...
B mRNA editing enzyme, catalytic polypeptide 1 (ApoBEC-1) as well as other auxiliary factors. ApoBEC-1 is a protein that in humans is encoded by the APOBEC1...
antigens. APOBEC family can also protect against the infection of RNA retroviruses and retrotransposons. In a single-strand DNA (ssDNA), APOBEC can transfer...
base. Active enzymatic deamination of cytosine or 5-methylcytosine by the APOBEC family of cytosine deaminases could have both beneficial and detrimental...
enzymes (cytidine deaminase/CDA, activation-induced cytidine deaminase and APOBEC protein family) actively cause cytidine deamination and therefore introduce...
C->U-editing enzyme APOBEC-1 is a protein that in humans is encoded by the APOBEC1 gene. This gene encodes a member of the APOBEC protein family and the...
and epigenetic, are collectively called dual inheritance. Members of the APOBEC/AID family of cytosine deaminases may concurrently influence genetic and...
activity-induced cytidine deaminase/apolipoprotein B mRNA editing complex (AID/APOBEC) deaminases to form 5-hydroxymethyluracil (5hmU) or 5mC can be converted...
an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". J. Biol. Chem...
enzyme APOBEC (specifically APOBEC3G, "A3G" in short, and other A3 enzymes) by targeting it for ubiquitination and cellular degradation. APOBEC is a cytidine...
protein ADM2 APOBEC3B: encoding protein probable DNA dC->dU-editing enzyme APOBEC-3B ARFGAP3: encoding protein ADP-ribosylation factor GTPase-activating protein...
3G) is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily of proteins. This family of proteins has been suggested to play...
viruses. APOBEC is a family of cytidine deaminases (enzymes) that are expressed in cells that are susceptible to HIV-1. She has shown that APOBEC Complex...
presumptive apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC)s expressed in lymphocytes—CDA1 and CDA2—have been discovered in P. marinus...
activity-induced cytidine deaminase/apolipoprotein B mRNA editing complex (AID/APOBEC) deaminases to form 5-hydroxymethyluracil (5hmU) or 5mC can be converted...
Probable C->U-editing enzyme APOBEC-2 is a protein that in humans is encoded by the APOBEC2 gene. GRCh38: Ensembl release 89: ENSG00000124701 – Ensembl...
DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is a...
activity-induced cytidine deaminase/apolipoprotein B mRNA editing complex (AID/APOBEC) deaminases to form 5-hydroxymethyluracil (5hmU) or 5mC can be converted...
oxidative deamination pathway, 5hmC can be oxidatively deaminated by APOBEC (AID/APOBEC) deaminases to form 5-hydroxymethyluracil (5hmU). Also, 5mC can be...
oxidative deamination pathway, 5hmC can be oxidatively deaminated by APOBEC (AID/APOBEC) deaminases to form 5-hydroxymethyluracil (5hmU) or 5mC can be converted...
Cervantes-Gracia K, Gramalla-Schmitz A, Weischedel J, Chahwan R (2021). "APOBECs orchestrate genomic and epigenomic editing across health and disease"....
selection pressures, patterns of insertion and deletion, and the impact of APOBEC". PLOS Pathog. 5 (5): e1000414. doi:10.1371/journal.ppat.1000414. PMC 2671846...
important in the innate immune defense against retroviruses, along with the APOBEC family of proteins, tetherin and TRIM22. TRIM5α belongs to the TRIM protein...
diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase". Nature Immunology. 8 (6): 647–56. doi:10.1038/ni1463...
methyl-seq (EM-seq) works similarly to bisulfite sequencing, but uses enzymes, APOBEC and TET2, to deaminate unmethylated cytosine into uracil prior to sequencing...
Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene. This gene is a member of the cytidine deaminase...
acidic pH, with maximal catalytic activity at pH 5.5. Another protein of the APOBEC family very similar to A3A, APOBEC3B, showed little activity at pH 4.5 and...
Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene. This gene is a member of the cytidine deaminase...
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