hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
cytidine deaminase activity
zinc ion binding
hydrolase activity
protein binding
catalytic activity
metal ion binding
deoxycytidine deaminase activity
RNA binding
Cellular component
cytoplasm
nucleus
Biological process
cellular response to xenobiotic stimulus
negative regulation of transposition
DNA demethylation
negative regulation of viral genome replication
innate immune response
defense response to virus
DNA cytosine deamination
immune system process
cytidine deamination
cytidine to uridine editing
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
200315
n/a
Ensembl
ENSG00000128383 ENSG00000262156
n/a
UniProt
P31941
n/a
RefSeq (mRNA)
NM_145699 NM_001270406
n/a
RefSeq (protein)
NP_001257335 NP_663745
n/a
Location (UCSC)
Chr 22: 38.95 – 38.99 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, or A3A is a gene of the APOBEC3 family found in humans, non-human primates, and some other mammals.[3] It is a single-domain DNA cytidine deaminase with antiviral effects. While other members of the family such as APOBEC3G are believed to act by editing ssDNA by removing an amino group from cytosine in DNA, introducing a cytosine to uracil change which can ultimately lead to a cytosine to thymine mutation, one study suggests that APOBEC3A can inhibit parvoviruses by another mechanism.[4] The cellular function of APOBEC3A is likely to be the destruction of foreign DNA through extensive deamination of cytosine.Stenglein MD, Burns MB, Li M, Lengyel J, Harris RS (February 2010). "APOBEC3 proteins mediate the clearance of foreign DNA from human cells". Nature Structural & Molecular Biology. 17 (2): 222–9. doi:10.1038/nsmb.1744. PMC 2921484. PMID 20062055.
This gene is a member of the polynucleotide cytosine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The APOBEC3 family of DNA editing enzymes are thought to be part of the innate immune system by restricting retroviruses, mobile genetic elements like retrotransposons and endogenous retroviruses. In addition, APOBEC3A is an important restrictive factor for HIV-1 and other retroviruses such as murine leukemia virus,[5][6]
^Narvaiza I, Linfesty DC, Greener BN, Hakata Y, Pintel DJ, Logue E, et al. (May 2009). Jung JU (ed.). "Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase". PLOS Pathogens. 5 (5): e1000439. doi:10.1371/journal.ppat.1000439. PMC 2678267. PMID 19461882.
^Jaguva Vasudevan AA, Becker D, Luedde T, Gohlke H, Münk C (March 2021). "Foamy Viruses, Bet, and APOBEC3 Restriction". Viruses. 13 (3): 504. doi:10.3390/v13030504. PMC 8003144. PMID 33803830.
^Stupfler B, Verriez C, Gallois-Montbrun S, Marquet R, Paillart JC (April 2021). "Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein". Viruses. 13 (4): 617. doi:10.3390/v13040617. PMC 8066197. PMID 33916704.
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, or A3A is a gene of the APOBEC3 family found in humans, non-human primates...
where the original A-T base pair transforms into a G-C base pair. APOBEC1 APOBEC3A-H, APOBEC3G - affects HIV Activation-induced cytidine deaminase (AICDA)...
encoding members of the APOBEC protein family include: APOBEC1 APOBEC2 APOBEC3A APOBEC3B APOBEC3C APOBEC3D ("APOBEC3E" now refers to this) APOBEC3F APOBEC3G...
viral infections by editing viral genome, but the enzymatic activity of APOBEC3A and APOBEC3B has also been found to cause unwanted host genome editing...
control. This gene along with APOBEC3A have been in recent years found associated with mutagenesis of several cancers. The APOBEC3A and APOBEC3B proteins can...
G-to-A mRNA changes in WT1 transcripts at two hotspots, proposing the APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3A) as the...
Haimov-Kochman, R., Nevo, Y., Stockheim, D., Yagel, S., Panet, A., Wolf, D.G., APOBEC3A is upregulated by human cytomegalovirus (HCMV) in the maternal-fetal interface...
abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells". PLOS Biology. 19 (3): e3001176. doi:10...
Davis J (September 2012). "Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients". Translational...
was first identified by Jarmuz et al. as a member of family of proteins APOBEC3A to 3G on chromosome 22 in 2002 and later also as a cellular factor able...
Fujiwara H, Yoshizaki T, Mori S, Kukimoto I, Muramatsu M (February 2015). "APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity". Biochemical...
Global Information
