hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
zinc ion binding
catalytic activity
hydrolase activity
metal ion binding
deoxycytidine deaminase activity
RNA binding
cytidine deaminase activity
Cellular component
nucleus
cytoplasm
Biological process
negative regulation of transposition
innate immune response
immune system process
defense response to virus
cytidine deamination
cytidine to uridine editing
DNA demethylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9582
80287
Ensembl
ENSG00000179750
ENSMUSG00000009585
UniProt
Q9UH17
Q99J72
RefSeq (mRNA)
NM_004900 NM_001270411
NM_001160415 NM_030255 NM_001347041
RefSeq (protein)
NP_001257340 NP_004891
NP_001153887 NP_001333970 NP_084531
Location (UCSC)
Chr 22: 38.98 – 38.99 Mb
Chr 15: 79.78 – 79.8 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene.[5][6][7]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. This gene along with APOBEC3A have been in recent years found associated with mutagenesis of several cancers. The APOBEC3A and APOBEC3B proteins can cause specific mutations in cancer genomes called APOBEC mutagenesis and several factors including genetic and environmental influence this mutation pattern among patients specifically in bladder and breast cancer.[7] This gene is also overexpressed in multiple myeloma, possibly aiding its formation.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000179750 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000009585 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
^Madsen P, Anant S, Rasmussen HH, Gromov P, Vorum H, Dumanski JP, Tommerup N, Collins JE, Wright CL, Dunham I, MacGinnitie AJ, Davidson NO, Celis JE (Sep 1999). "Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1". J Invest Dermatol. 113 (2): 162–9. doi:10.1046/j.1523-1747.1999.00682.x. PMID 10469298.
dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene. This gene is a member of the cytidine deaminase gene family. It is...
members of the APOBEC protein family include: APOBEC1 APOBEC2 APOBEC3A APOBEC3B APOBEC3C APOBEC3D ("APOBEC3E" now refers to this) APOBEC3F APOBEC3G APOBEC3H...
see the link in the infobox on the right. ADM2: encoding protein ADM2 APOBEC3B: encoding protein probable DNA dC->dU-editing enzyme APOBEC-3B ARFGAP3:...
infections by editing viral genome, but the enzymatic activity of APOBEC3A and APOBEC3B has also been found to cause unwanted host genome editing and may even...
cells. Recent evidence has linked the over-expression of the family member APOBEC3B with multiple human cancers, highlighting its possible contribution to...
mitotic catastrophe. Another study examined how replication stress affected APOBEC3B activity. APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like...
cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B". The Biochemical Journal. 471 (1): 25–35...
Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004). "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication"...
Ribeiro, AC; Gonçalves, J; Strebel, K; Barahona, I (9 November 2021). "APOBEC3B Potently Restricts HIV-2 but Not HIV-1 in a Vif-Dependent Manner". Journal...
activity at pH 5.5. Another protein of the APOBEC family very similar to A3A, APOBEC3B, showed little activity at pH 4.5 and 4.0 and a similar assumption can...
Hoopes JI, Cortez LM, Mertz TM, et al. (February 2016). "APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication"...
changes. Potentially important examples include: 1) overexpression of the APOBEC3B gene whose protein product (termed "probable DNA dC->dU-editing enzyme...
Mukerji also did work studying correlations between polymorphisms in the APOBEC3B gene and malaria susceptibility. Many versions of this gene with various...
3112-3115.2006. PMC 1395459. PMID 16501124. Stenglein MD, Harris RS (2006). "APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent...
Global Information
