PTPN22 information

PTPN22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P6X, 2QCJ, 2QCT, 3BRH, 3H2X, 3OLR, 3OMH, 4J51
Identifiers
Aliases	PTPN22, protein tyrosine phosphatase, non-receptor type 22 (lymphoid), LYP, LYP1, LYP2, PEP, PTPN8, protein tyrosine phosphatase, non-receptor type 22, PTPN22.6, PTPN22.5, protein tyrosine phosphatase non-receptor type 22
External IDs	OMIM: 600716; MGI: 107170; HomoloGene: 7498; GeneCards: PTPN22; OMA:PTPN22 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	113,871,753 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	103,819,563 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; granulocyte; ; buccal mucosa cell; ; blood; ; Achilles tendon; ; superficial temporal artery; ; lymph node; ; epithelium of nasopharynx; ; spleen;
	Top expressed in
	thymus; ; spleen; ; granulocyte; ; lymph node; ; mesenteric lymph nodes; ; zygote; ; blood; ; secondary oocyte; ; primary oocyte; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; SH3 domain binding; phosphatase activity; kinase binding; protein binding; hydrolase activity; ubiquitin protein ligase binding; protein tyrosine phosphatase activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; cytoplasmic side of plasma membrane; nucleus; cytosol;
Biological process	positive regulation of protein K63-linked ubiquitination; regulation of NIK/NF-kappaB signaling; regulation of innate immune response; regulation of natural killer cell proliferation; positive regulation of toll-like receptor 3 signaling pathway; regulation of T cell receptor signaling pathway; regulation of B cell receptor signaling pathway; phosphoanandamide dephosphorylation; immune system process; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; negative regulation of p38MAPK cascade; protein dephosphorylation; negative regulation of gene expression; negative regulation of T cell receptor signaling pathway; cellular response to muramyl dipeptide; autophagy; response to lipopolysaccharide; T cell differentiation; positive regulation of gene expression; positive regulation of ERK1 and ERK2 cascade; positive regulation of toll-like receptor 4 signaling pathway; negative regulation of tumor necrosis factor production; negative regulation of autophagy; negative regulation of JUN kinase activity; negative regulation of T cell activation; positive regulation of type I interferon production; lipopolysaccharide-mediated signaling pathway; dephosphorylation; peptidyl-tyrosine dephosphorylation; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	26191
	19260
	ENSG00000134242
	ENSMUSG00000027843
	Q9Y2R2
	P29352
	NM_001193431; NM_001308297; NM_012411; NM_015967
	NM_008979
	NP_001180360; NP_001295226; NP_036543; NP_057051
	NP_033005
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein is also called "PEST-domain Enriched Phosphatase" ("PEP") or "Lymphoid phosphatase" ("LYP"). The name LYP is used strictly for the human protein encoded by PTPN22, but the name PEP is used only for its mouse homolog. However, both proteins have similar biological functions and show 70% identity in amino acid sequence. PTPN22 functions as a negative regulator of T cell receptor (TCR) signaling, which maintains homeostasis of T cell compartment.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134242 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027843 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bottini N, Peterson EJ (2014-03-21). "Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease". Annual Review of Immunology. 32 (1): 83–119. doi:10.1146/annurev-immunol-032713-120249. PMC 6402334. PMID 24364806.
^ Tizaoui K, Terrazzino S, Cargnin S, Lee KH, Gauckler P, Li H, et al. (June 2021). "The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review". Seminars in Arthritis and Rheumatism. 51 (3): 513–522. doi:10.1016/j.semarthrit.2021.03.004. PMID 33866147. S2CID 233300534.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134242 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027843 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Bottini N, Peterson EJ (2014-03-21). "Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease". Annual Review of Immunology. 32 (1): 83–119. doi:10.1146/annurev-immunol-032713-120249. PMC 6402334. PMID 24364806.

[:1-6] Tizaoui K, Terrazzino S, Cargnin S, Lee KH, Gauckler P, Li H, et al. (June 2021). "The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review". Seminars in Arthritis and Rheumatism. 51 (3): 513–522. doi:10.1016/j.semarthrit.2021.03.004. PMID 33866147. S2CID 233300534.

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