YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases.[5]YAP1 is a potent oncogene, which is amplified in various human cancers.[6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000137693 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000053110 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes...
Sasajima Y, Goshima N, Yamazaki N, Mori T (May 2019). "Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma". The Journal of Clinical...
contain at least one of two YAP1 fusion genes, i.e. abnormal genes caused by a mutation which merges a part of the YAP1 gene fused to part of either...
oxidative burst with an oxidative stress response, regulated by the gene YAP1. The response protects U. maydis from the host defense, and is necessary...
Jiangmen. An alternative term, Wuyi (Chinese: 五邑; pinyin: Wǔyì, Cantonese: Ng5 Yap1; 'five counties'), which refers to the five former counties of Xinhui, Taishan...
STRA6 TBC1D20 TBC1D32 TBX22 TCOF1 TENM3 TFAP2A TMEM98 TMEM67 TMX3 VAX1 VSX2 YAP1 ZEB2 ZIC2 SOX2 has been implicated in a substantial number (10–15%) of cases...
actin cytoskeleton detects changes and transmits them downstream through YAP1. Calcium-dependent cell adhesion molecules such as cadherins and selectins...
The YAP1 gene product, yes-associated protein, contributes to the regulation of cell proliferation and apoptosis, i.e. programmed cell death (see YAP1)....
been to understand signaling modalities of WW domain-containing YAP (aka YAP1) oncoprotein and crosstalk of other WW domain-containing proteins in the...
stress and alkaline pH sensing were contributed from the transcription factor Yap1 and Rim101 of the Papiliotrema terrestris LS28 as molecular tools revealed...
such an oxidative burst by an oxidative stress response, regulated by gene YAP1. This response protects U. maydis from the host attack, and is necessary...
both in the same region but both did not promote cancer growth. PMP22 , YAP1. GRCh38: Ensembl release 89: ENSG00000143001 – Ensembl, May 2017 GRCm38:...
two-hybrid screening. A few notable examples include: LATS2: Negatively regulates YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control...
the YAP1-NUTM1 and WWTR1-NUTM1 fusion genes in 21 cases and 1 case, respectively, while the same study of 11 porocarcinoma tumors detected the YAP1-NUTM1...
metallofluorenol, can competitively inhibit the WW domain in the oncogene YAP1 from activating. It was originally developed as an MRI contrast agent. Endohedral...
translocations. During translocations, a fusion protein is formed between YAP1, a gene crucial for proliferation and apoptosis (programmed cell death) of...
microRNA significantly decreased expression of SP1 and YAP1 in colorectal cancer cells. SP1 and YAP1 mRNAs are direct targets of miR-375-5p. Transcription...
by the analysis of two splice isoforms of YAP gene product, named YAP1-1 and YAP1-2, which differed by the presence of an extra 38 amino acids. These...
Colobomatous microphthalmia-obesity-hypogenitalism-intellectual disability syndrome YAP1 AD Coloboma, ocular, with or without hearing impairment, cleft lip/palate...
member 3 protein, a product of the VGLL3 gene, and YAP1, i.e. yes-associated protein 1, a product of the YAP1 gene, in the Hippo signaling pathway; 2) Abnormal...
sclerosis type 19. ERBB4 has been shown to interact with: DLG4 NRG1, STAT5A, and YAP1. GRCh38: Ensembl release 89: ENSG00000178568 – Ensembl, May 2017 GRCm38:...
shown to interact with PRKRIR. STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis. GRCh38: Ensembl...
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