protein serine/threonine kinase activator activity
metal ion binding
kinase activity
protein serine/threonine kinase activity
protein binding
identical protein binding
ATP binding
magnesium ion binding
Cellular component
cytoplasm
nucleus
nucleoplasm
cytosol
nuclear body
protein-containing complex
Biological process
regulation of cell differentiation involved in embryonic placenta development
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of protein phosphorylation
intracellular signal transduction
phosphorylation
protein stabilization
hippo signaling
keratinocyte differentiation
positive regulation of peptidyl-serine phosphorylation
endocardium development
protein phosphorylation
primitive hemopoiesis
central nervous system development
peptidyl-serine phosphorylation
cell morphogenesis
positive regulation of apoptotic process
branching involved in blood vessel morphogenesis
protein autophosphorylation
positive regulation of protein binding
cell differentiation involved in embryonic placenta development
positive regulation of fat cell differentiation
negative regulation of organ growth
neural tube formation
negative regulation of canonical Wnt signaling pathway
signal transduction
negative regulation of cell population proliferation
hepatocyte apoptotic process
apoptotic process
positive regulation of protein serine/threonine kinase activity
regulation of mitotic cell cycle
stress-activated protein kinase signaling cascade
positive regulation of vascular associated smooth muscle cell apoptotic process
activation of protein kinase activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6789
58231
Ensembl
ENSG00000101109
ENSMUSG00000018209
UniProt
Q13043
Q9JI11
RefSeq (mRNA)
NM_006282 NM_001352385
NM_021420
RefSeq (protein)
NP_006273 NP_001339314
NP_067395
Location (UCSC)
Chr 20: 44.97 – 45.08 Mb
Chr 2: 163.91 – 164 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000101109 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000018209 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. Bibcode:1996PNAS...9310099T. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
^Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. doi:10.1093/emboj/17.8.2224. PMC 1170567. PMID 9545236.
^Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. Bibcode:2001PNAS...9810148U. doi:10.1073/pnas.181161698. PMC 56930. PMID 11517310.
Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene. The protein encoded by this gene is a cytoplasmic kinase that is structurally...
growth-controlling genes. The serine/threonine kinase Hippo (Mst1/Mst2 encoded by the STK4 and STK3 genes respectively in mammals) activates a secondary kinase (Lats1/Lats2)...