Nuclear pore glycoprotein p62 information

NUP62
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IJN, 5IJO
Identifiers
Aliases	NUP62, IBSN, SNDI, p62, nucleoporin 62kDa, nucleoporin 62
External IDs	OMIM: 605815; MGI: 1351500; HomoloGene: 68773; GeneCards: NUP62; OMA:NUP62 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,929,763 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,480,236 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; granulocyte; ; embryo; ; ganglionic eminence; ; monocyte; ; oocyte; ; appendix; ; ventricular zone; ; glutes;
	Top expressed in
	condyle; ; primitive streak; ; endothelial cell of lymphatic vessel; ; fossa; ; secondary oocyte; ; zygote; ; hair follicle; ; endocardial cushion; ; tail of embryo; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	Hsp90 protein binding; SH2 domain binding; chromatin binding; thyroid hormone receptor binding; PTB domain binding; Hsp70 protein binding; protein binding; ubiquitin binding; signaling receptor complex adaptor activity; structural constituent of nuclear pore; phospholipid binding; kinesin binding;
Cellular component	nuclear membrane; Flemming body; nuclear pore; lamellae anulatae; cytoskeleton; nuclear pore central transport channel; spindle pole; cytoplasm; centrosome; mitotic spindle; nuclear envelope; microtubule organizing center; nucleus; protein-containing complex; ribonucleoprotein complex; host cell;
Biological process	mRNA transport; negative regulation of epidermal growth factor receptor signaling pathway; regulation of Ras protein signal transduction; cell death; negative regulation of apoptotic process; transcription, DNA-templated; negative regulation of Ras protein signal transduction; positive regulation of transcription, DNA-templated; cell surface receptor signaling pathway; regulation of signal transduction; negative regulation of MAP kinase activity; spermatogenesis; regulation of protein import into nucleus; hormone-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein transport; negative regulation of programmed cell death; nuclear transport; viral process; positive regulation of epidermal growth factor receptor signaling pathway; negative regulation of cell population proliferation; protein import into nucleus; mRNA export from nucleus; mitotic metaphase plate congression; mitotic centrosome separation; positive regulation of mitotic nuclear division; positive regulation of centriole replication; regulation of mitotic spindle organization; centriole assembly; positive regulation of mitotic cytokinetic process; positive regulation of protein localization to centrosome; centrosome cycle; mitotic cell cycle; protein heterotrimerization; regulation of glycolytic process; tRNA export from nucleus; protein sumoylation; viral transcription; regulation of gene silencing by miRNA; intracellular transport of virus; regulation of cellular response to heat;
	Sources:Amigo / QuickGO
Orthologs
	23636
	18226
	ENSG00000213024
	ENSMUSG00000109511
	P37198
	Q63850
	NM_153719; NM_001193357; NM_012346; NM_016553; NM_153718
	NM_053074
	NP_001180286; NP_036478; NP_057637; NP_714940; NP_714941
	NP_444304
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa^[5] followed by modification that involve addition of N-acetylglucosamine residues,^[6] followed by association with other complex proteins. In humans it is encoded by the NUP62 gene.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213024 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000109511 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davis LI, Blobel G (1986). "Identification and characterization of a nuclear pore complex protein". Cell. 45 (5): 699–709. doi:10.1016/0092-8674(86)90784-1. PMID 3518946. S2CID 22170880.
^ Davis LI, Blobel G (1987). "Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7552–6. Bibcode:1987PNAS...84.7552D. doi:10.1073/pnas.84.21.7552. PMC 299337. PMID 3313397.
^ "Entrez Gene: NUP62 nucleoporin 62kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213024 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000109511 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3518946-5] Davis LI, Blobel G (1986). "Identification and characterization of a nuclear pore complex protein". Cell. 45 (5): 699–709. doi:10.1016/0092-8674(86)90784-1. PMID 3518946. S2CID 22170880.

[pmid3313397-6] Davis LI, Blobel G (1987). "Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7552–6. Bibcode:1987PNAS...84.7552D. doi:10.1073/pnas.84.21.7552. PMC 299337. PMID 3313397.

[entrez-7] "Entrez Gene: NUP62 nucleoporin 62kDa".

Nuclear pore glycoprotein p62 information

and 8 Related for: Nuclear pore glycoprotein p62 information

Nuclear pore glycoprotein p62

Antinuclear antibody

Nucleoporin 54

Autoantibody

NUP98

NUTF2

SSR1

Primary biliary cholangitis