CDKN1B information

CDKN1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AST, 1H27, 1JSU
Identifiers
Aliases	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
External IDs	OMIM: 600778 MGI: 104565 HomoloGene: 2999 GeneCards: CDKN1B
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,722,369 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	134,902,476 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; ganglionic eminence; ; pons; ; trabecular bone; ; parietal pleura; ; superficial temporal artery; ; germinal epithelium; ; cerebellar vermis; ; subthalamic nucleus; ; endothelial cell;
	Top expressed in
	cerebellar vermis; ; blood; ; pineal gland; ; cumulus cell; ; habenula; ; ganglionic eminence; ; seminal vesicula; ; median eminence; ; dorsomedial hypothalamic nucleus; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein phosphatase binding; cyclin-dependent protein serine/threonine kinase activity; protein kinase inhibitor activity; protein kinase binding; cyclin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; Hsp70 protein binding; protein-containing complex binding; chaperone binding;
Cellular component	cytoplasm; cytosol; endosome; nucleoplasm; Cul4A-RING E3 ubiquitin ligase complex; nucleus; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	Notch signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to estradiol; positive regulation of cell death; response to hypoxia; response to amino acid; response to cadmium ion; positive regulation of protein catabolic process; response to organic cyclic compound; cellular response to lithium ion; cellular response to organic cyclic compound; response to peptide hormone; cell death; negative regulation of apoptotic process; sensory perception of sound; response to glucose; potassium ion transport; regulation of cell population proliferation; negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; positive regulation of microtubule polymerization; inner ear development; cellular response to antibiotic; cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-templated; autophagic cell death; negative regulation of cell population proliferation; negative regulation of mitotic cell cycle; negative regulation of kinase activity; positive regulation of cell cycle; negative regulation of vascular associated smooth muscle cell proliferation; placenta development; regulation of exit from mitosis; regulation of lens fiber cell differentiation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1027
	12576
	ENSG00000111276
	ENSMUSG00000003031
	P46527
	P46414
	NM_004064
	NM_009875
	NP_004055
	NP_034005
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase inhibitor 1B (p27^Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene.^[5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111276 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003031 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massagué J (August 1994). "Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals". Cell. 78 (1): 59–66. doi:10.1016/0092-8674(94)90572-X. PMID 8033212. S2CID 38513201.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111276 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003031 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8033212-5] Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massagué J (August 1994). "Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals". Cell. 78 (1): 59–66. doi:10.1016/0092-8674(94)90572-X. PMID 8033212. S2CID 38513201.

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