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Acenocoumarol information


Acenocoumarol
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • X
Routes of
administration
Oral
ATC code
  • B01AA07 (WHO)
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
MetabolismHepatic
Elimination half-life8 to 11 hours
Identifiers
IUPAC name
  • (RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
CAS Number
  • 152-72-7 checkY
PubChem CID
  • 9052
DrugBank
  • DB01418 checkY
ChemSpider
  • 10443441 checkY
UNII
  • I6WP63U32H
KEGG
  • D07064 checkY
ChEBI
  • CHEBI:53766 checkY
ChEMBL
  • ChEMBL397420 checkY
CompTox Dashboard (EPA)
  • DTXSID2022541 Edit this at Wikidata
ECHA InfoCard100.005.281 Edit this at Wikidata
Chemical and physical data
FormulaC19H15NO6
Molar mass353.330 g·mol−1
3D model (JSmol)
  • Interactive image
ChiralityRacemic mixture
Melting point196 to 199 °C (385 to 390 °F)
SMILES
  • CC(=O)CC(C1=CC=C(C=C1)[N+](=O)[O-])C2=C(OC3=CC=CC=C3C2=O)O
InChI
  • InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3 checkY
  • Key:VABCILAOYCMVPS-UHFFFAOYSA-N checkY
  (verify)

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.[1]

  1. ^ "International listings for acenocoumarol". Drugs.com.

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Acenocoumarol

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Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed...

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Chlortetracycline

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rare. Chlortetracycline may increase the anticoagulant activities of acenocoumarol. The risk or severity of adverse effects can be increased when chlortetracycline...

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Pulmonary embolism

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treatment. For many years, vitamin K antagonists (warfarin or less commonly acenocoumarol or phenprocoumon) have been the cornerstone. As vitamin K antagonists...

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Drug interaction

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Brassicas (Brussels sprouts, broccoli, cabbage) Enzymatic inductor Acenocoumarol, warfarin Grapefruit juice Enzymatic inhibition Calcium channel blockers:...

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Coagulation

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target of anticoagulant drugs warfarin and related coumarins such as acenocoumarol, phenprocoumon, and dicumarol. These drugs create a deficiency of reduced...

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Verification and validation

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(2008). "Improvement in the regulation of the vitamin K antagonist acenocoumarol after a standard initial dose regimen: prospective validation of a prescription...

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Coumarin

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neurological dysfunction was found in children exposed to the anticoagulants acenocoumarol or phenprocoumon during pregnancy. A group of 306 children were tested...

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Rivaroxaban

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be injected, whereas the orally active warfarin, phenprocoumon, and acenocoumarol are vitamin K antagonists (VKA), decreasing a number of coagulation...

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Vitamin K antagonist

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4-hydroxycoumarins. Warfarin (Coumadin) Coumatetralyl Phenprocoumon Acenocoumarol Dicoumarol Tioclomarol Brodifacoum Another group of VKAs are 1,3-indandione...

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Ofloxacin

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fluoroquinolones have been shown to increase the anticoagulant effect of acenocoumarol, anisindione, and dicumarol. Additionally, the risk of cardiotoxicity...

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Factor X

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some European countries, other coumarin derivatives (phenprocoumon and acenocoumarol) are used. These agents known as vitamin K antagonists (VKA), inhibit...

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Anticoagulant

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fibrillation (AF), and mechanical prosthetic heart valves. Other examples are acenocoumarol, phenprocoumon, atromentin, and phenindione.[citation needed] The coumarins...

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ATC code B01

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B01AA02 Phenindione B01AA03 Warfarin B01AA04 Phenprocoumon B01AA07 Acenocoumarol B01AA08 Ethyl biscoumacetate B01AA09 Clorindione B01AA10 Diphenadione...

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Warfarin

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coumarins are used instead of warfarin, such as acenocoumarol and phenprocoumon. These have a shorter (acenocoumarol) or longer (phenprocoumon) half-life, and...

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CYP2C9

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warfarin and phenytoin, and other routinely prescribed drugs such as acenocoumarol, tolbutamide, losartan, glipizide, and some nonsteroidal anti-inflammatory...

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CYP4F2

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the dosing of vitamin K antagonists such as warfarin, coumarin, or acenocoumarol. The enzyme also regulates the bioactivation of certain drugs, such...

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