Vesicle fusion is the merging of a vesicle with other vesicles or a part of a cell membrane. In the latter case, it is the end stage of secretion from secretory vesicles, where their contents are expelled from the cell through exocytosis. Vesicles can also fuse with other target cell compartments, such as a lysosome. Exocytosis occurs when secretory vesicles transiently dock and fuse at the base of cup-shaped structures at the cell plasma membrane called porosome, the universal secretory machinery in cells. Vesicle fusion may depend on SNARE proteins in the presence of increased intracellular calcium (Ca2+) concentration.
Vesiclefusion is the merging of a vesicle with other vesicles or a part of a cell membrane. In the latter case, it is the end stage of secretion from...
translocation and fusion of the post-Golgi vesicles to the plasma membrane. The fusion involves membrane tethering (recognition) and membrane fusion. It is still...
After the synaptic vesicles initially dock, they must be primed before they can begin fusion. Priming prepares the synaptic vesicle so that they are able...
the fusion complex. SNAPs are involved in the priming of the vesiclefusion complex during assembly, as well as in the disassembly following a vesicle fusion...
to mediate the fusion of vesicles with the target membrane; this notably mediates exocytosis, but can also mediate the fusion of vesicles with membrane-bound...
vesiclefusion is in close proximity to calcium channels and that vesiclefusion is adjacent to postsynaptic receptors. This close proximity vesicle fusion...
facilitator of synaptic vesiclefusion and neurotransmitter release. In one conformation, it clamps SNAREpin complexes, preventing vesiclefusion, while in a different...
where secretory vesicles transiently dock in the process of vesiclefusion and secretion. The transient fusion of secretory vesicle membrane at a porosome...
footprint (bright spots in the top cell in the right panel). An example of vesiclefusion in chromaffin cells using IRM is shown in movie 1. Upon stimulation...
in vitro with synthetic lipid vesicles. These studies have shown that divalent cations play a critical role in the fusion process by binding to negatively...
encoded protein may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. It is...
ions bind to sensor proteins (synaptotagmins) on synaptic vesicles, triggering vesiclefusion with the cell membrane and subsequent neurotransmitter release...
involved in vesicle trafficking, specifically the tethering and spatial targeting of post-Golgi vesicles to the plasma membrane prior to vesiclefusion. It is...
proteins underlying vesiclefusion. This cell line has been used to understand the role of synaptotagmin in vesicle-cell membrane fusion. Their embryological...
for NSF binding. Synaptobrevin is an integral V-SNARE necessary for vesiclefusion to membranes. The final target of TeNT is the cleavage of synaptobrevin...
accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes...
channels, activation of potassium channels, and direct inhibition of the vesiclefusion process. Endocannabinoids, synthesized in and released from postsynaptic...
described by uniquantal (i.e., univesicular) release shaped by a flickering vesiclefusion pore. These unique features specialize the ribbon synapse to enable...
insulin is cleaved from proinsulin in the secretory vesicles). Eventually, there is vesiclefusion with the cell membrane at porosomes, by a process called...
concentrations, nystatin momentarily forms pores that allows a vesiclefusion to occur more easily; that fusion then interrupts the pore stability and the nystatin...
synaptic vesicle docking to the presynaptic membrane via interaction with β-neurexin or SNAP-25 late steps of Ca2+-evoked synaptic vesiclefusion with the...
the vesicle for the neuron cytosol, where it cleaves vesicle associated membrane protein (VAMP) synaptobrevin, which is necessary for membrane fusion of...
of SNARE complex. The SNARE complex mediates vesiclefusion by creating tight complex that brings vesicle and membrane together. This protein causes ubiquitous...