SNAP47 information

SNAP47
Identifiers
Aliases	SNAP47, C1orf142, HEL170, SNAP-47, SVAP1, ESFI5812, HEL-S-290, synaptosome associated protein 47kDa, synaptosome associated protein 47, uncharacterized LOC100130093
External IDs	MGI: 1915076 HomoloGene: 14206 GeneCards: SNAP47
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	59,342,012 bp
Gene ontology
Molecular function	SNAP receptor activity; syntaxin binding; protein binding;
Cellular component	SNARE complex; perinuclear region of cytoplasm; endomembrane system; plasma membrane; BLOC-1 complex; membrane; cytoplasm; neuronal cell body; dendrite; synaptic vesicle membrane; glutamatergic synapse; postsynaptic density; asymmetric synapse; hippocampal mossy fiber to CA3 synapse;
Biological process	synaptic vesicle priming; long-term potentiation; synaptic vesicle fusion to presynaptic active zone membrane; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; vesicle-mediated transport in synapse; exocytosis; vesicle fusion;
	Sources:Amigo / QuickGO
Orthologs
	116841
	67826
	ENSG00000143740
	ENSMUSG00000009894
	Q5SQN1
	Q8R570
	n/a
	NM_144521; NM_001356452; NM_001356454
NP_001310859; NP_001310860; NP_001310861; NP_001310862; NP_001310863;
	NP_001310864; NP_444280
	NP_653104; NP_001343381; NP_001343383
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptosome-associated protein, 47 kDal (SNAP47) is a human protein encoded by the SNAP47 gene.^[4]^[5]^[6] Other aliases of this gene are SVAP1, HEL170, ESFI5812, and HEL-S-290. SNAP47 is a synaptosome protein which is associated with the protein coding in multiple diseases, including non small cell lung cancer and schizophrenia. SNAP47 is a member of the SNAP protein family. SNAP proteins are t-snare proteins that are a component of SNARE complex. The SNARE complex mediates vesicle fusion by creating tight complex that brings vesicle and membrane together.^[7] This protein causes ubiquitous expression in testis, ovary, and many other tissues^[8]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009894 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2020-07-28.
^ "SNAP47 - Synaptosomal-associated protein 47 - Homo sapiens (Human) - SNAP47 gene & protein". www.uniprot.org. UniProt. Retrieved 2020-08-01.
^ "SNAP47 synaptosome associated protein 47 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2020-08-01.
^ Rizo, Josep; Südhof, Thomas C. (August 2002). "Snares and Munc18 in synaptic vesicle fusion". Nature Reviews. Neuroscience. 3 (8): 641–653. doi:10.1038/nrn898. ISSN 1471-003X. PMID 12154365. S2CID 13351502.
^ "SNAP47 synaptosome associated protein 47 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-06-10.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000009894 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2020-07-28.

[5] "SNAP47 - Synaptosomal-associated protein 47 - Homo sapiens (Human) - SNAP47 gene & protein". www.uniprot.org. UniProt. Retrieved 2020-08-01.

[6] "SNAP47 synaptosome associated protein 47 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2020-08-01.

[7] Rizo, Josep; Südhof, Thomas C. (August 2002). "Snares and Munc18 in synaptic vesicle fusion". Nature Reviews. Neuroscience. 3 (8): 641–653. doi:10.1038/nrn898. ISSN 1471-003X. PMID 12154365. S2CID 13351502.

[:0-8] "SNAP47 synaptosome associated protein 47 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-06-10.