uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
Identifiers
Symbol
UPRT
NCBI gene
139596
HGNC
28334
RefSeq
NM_145052
UniProt
Q96BW1
Other data
Locus
Chr. X q13.3
Search for
Structures
Swiss-model
Domains
InterPro
Uracil phosphoribosyltransferase is an enzyme which creates UMP from uracil and phosphoribosylpyrophosphate. This protein may use the morpheein model of allosteric regulation.[1]
^Selwood T, Jaffe EK (March 2012). "Dynamic dissociating homo-oligomers and the control of protein function". Archives of Biochemistry and Biophysics. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.
and 23 Related for: Uracil phosphoribosyltransferase information
Uracilphosphoribosyltransferase is an enzyme which creates UMP from uracil and phosphoribosylpyrophosphate. This protein may use the morpheein model...
Hypoxanthine-guanine phosphoribosyltransferase Orotate phosphoribosyltransferase Quinolinate phosphoribosyltransferaseUracilphosphoribosyltransferase v t e...
form of uracil. Uracil also recycles itself to form nucleotides by undergoing a series of phosphoribosyltransferase reactions. Degradation of uracil produces...
N-alkylation of anthranilic acid catalysed by the enzyme anthranilate phosphoribosyltransferase. Increased levels of PRPP are characterized by the overproduction...
is enhanced by expression of the fusion cytosine deaminase/uracilphosphoribosyltransferase suicide gene". Cancer Research. 63 (23): 8366–76. PMID 14678998...
are two types of phosphoribosyltransferases: adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT). HGPRT...
Lesch–Nyhan syndrome is caused by a deficiency in hypoxanthine-guanine phosphoribosyltransferase or HGPRT, the enzyme that catalyzes the reversible reaction of...
(3q13). This bifunctional enzyme has two main domains, an orotate phosphoribosyltransferase (OPRTase, EC 2.4.2.10) subunit and an orotidine-5’-phosphate decarboxylase...
Oligomeric States are Involved in the Allosteric Behavior of UracilPhosphoribosyltransferase from Escherichia Coli". European Journal of Biochemistry. 240...
nucleobases in DNA are guanine, adenine, cytosine, and thymine; in RNA, uracil is used in place of thymine. Nucleotides also play a central role in metabolism...
inhibiting the enzyme dihydropyrimidine dehydrogenase (uracil/gimeracil) or orotate phosphoribosyltransferase (oteracil). The major side effects of tegafur are...
Uridine (symbol U or Urd) is a glycosylated pyrimidine analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic...
mitochondria. UMPS is a bifunctional enzyme consisting of orotate phosphoribosyltransferase (OPRT) and orotidine monophosphate decarboxylase (OMPDC). Both...
adenine phosphoribosyltransferase. It is also used to treat kidney stones caused by deficient activity of adenine phosphoribosyltransferase. Allopurinol...
and gout. It is caused by the absence of hypoxanthine-guanine phosphoribosyltransferase, which is a necessary enzyme for purine nucleotide formation....
hypoxanthine by xanthine oxidoreductase. Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage. Hypoxanthine...
riboswitch is detailed below. The xpt gene encodes a specific xanthine phosphoribosyltransferase protein, which is involved in purine metabolism. Unlike the add...
Global Information